دورية أكاديمية
أعرض في EDS

Human C1q Regulates Influenza A Virus Infection and Inflammatory Response via Its Globular Domain.

التفاصيل البيبلوغرافية
العنوان: Human C1q Regulates Influenza A Virus Infection and Inflammatory Response via Its Globular Domain.
المؤلفون: Varghese PM; Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, London UB8 3PH, UK.; School of Biosciences and Technology, Vellore Institute of Technology, Vellore 632014, India., Kishore U; Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, London UB8 3PH, UK., Rajkumari R; School of Biosciences and Technology, Vellore Institute of Technology, Vellore 632014, India.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Mar 11; Vol. 23 (6). Date of Electronic Publication: 2022 Mar 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Influenza A Virus, H1N1 Subtype* , Influenza A virus* , Influenza, Human*, Complement C1q ; Complement System Proteins ; Humans ; Influenza A Virus, H3N2 Subtype
مستخلص: The Influenza A virus (IAV) is a severe respiratory pathogen. C1q is the first subcomponent of the complement system's classical pathway. C1q is composed of 18 polypeptide chains. Each of these chains contains a collagen-like region located at the N terminus, and a C-terminal globular head region organized as a heterotrimeric structure (ghA, ghB and ghC). This study was aimed at investigating the complement activation-independent modulation by C1q and its individual recombinant globular heads against IAV infection. The interaction of C1q and its recombinant globular heads with IAV and its purified glycoproteins was examined using direct ELISA and far-Western blotting analysis. The effect of the complement proteins on IAV replication kinetics and immune modulation was assessed by qPCR. The IAV entry inhibitory properties of C1q and its recombinant globular heads were confirmed using cell binding and luciferase reporter assays. C1q bound IAV virions via HA, NA and M1 IAV proteins, and suppressed replication in H1N1, while promoting replication in H3N2-infected A549 cells. C1q treatment further triggered an anti-inflammatory response in H1N1 and pro-inflammatory response in H3N2-infected cells as evident from differential expression of TNF-α, NF-κB, IFN-α, IFN-β, IL-6, IL-12 and RANTES. Furthermore, C1q treatment was found to reduce luciferase reporter activity of MDCK cells transfected with H1N1 pseudotyped lentiviral particles, indicative of an entry inhibitory role of C1q against infectivity of IAV. These data appear to demonstrate the complement-independent subtype specific modulation of IAV infection by locally produced C1q.
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فهرسة مساهمة: Keywords: RNA viruses; classical pathway; complement; cytokine storm; human C1q; immune evasion; influenza A virus; innate immunity
المشرفين على المادة: 80295-33-6 (Complement C1q)
9007-36-7 (Complement System Proteins)
تواريخ الأحداث: Date Created: 20220325 Date Completed: 20220408 Latest Revision: 20220531
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8949502
DOI: 10.3390/ijms23063045
PMID: 35328462
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms23063045