دورية أكاديمية
AMFR drives allergic asthma development by promoting alveolar macrophage-derived GM-CSF production.
| العنوان: | AMFR drives allergic asthma development by promoting alveolar macrophage-derived GM-CSF production. |
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| المؤلفون: | Zhang H; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P.R. China., Wei R; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, P.R. China., Yang X; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P.R. China., Xu L; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P.R. China., Jiang H; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P.R. China., Li M; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P.R. China., Jiang H; School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, P.R. China., Zhang H; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P.R. China., Chen Z; Department of Respiratory and Critical Care Medicine of Zhongshan Hospital, Shanghai Institute of Respiratory Disease, Fudan University, Shanghai, P.R. China., Qian F; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P.R. China., Sun L; Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, Pharm-X Center, School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P.R. China. |
| المصدر: | The Journal of experimental medicine [J Exp Med] 2022 May 02; Vol. 219 (5). Date of Electronic Publication: 2022 Mar 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Rockefeller University Press |
| مواضيع طبية MeSH: | Asthma* , Macrophages, Alveolar*/metabolism , Receptors, Autocrine Motility Factor*/metabolism, Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Humans ; Inflammation/metabolism |
| مستخلص: | Alveolar macrophages (AMs) are specialized tissue-resident macrophages that orchestrate the immune response in allergic inflammation and asthma. However, what signals direct AMs to cross talk with other immune cells remains unclear. Here, we report that autocrine motility factor receptor (AMFR), an endoplasmic reticulum-resident E3 ubiquitin ligase, is upregulated in AMs of asthma and is critical for this condition. AMFR deficiency significantly decreased allergy-induced T helper 2 (Th2) and eosinophilic inflammation, with less granulocyte-macrophage colony-stimulating factor (GM-CSF) production in AMs. Mechanistically, following thymic stromal lymphopoietin (TSLP) stimulation, AMFR associated directly with cytokine-inducible SH2-containing protein (CIS), induced the ubiquitination of Lys48-linked polyubiquitination of CIS, and consequently blocked the inhibitory effect of CIS on signal transducer and activator of transcription 5 (STAT5) phosphorylation and the downstream pathway activation in AMs. In conclusion, our results demonstrate that AMFR serves a crucial role in promoting inflammation in asthma through regulating AM function, and may emerge as a new potential drug target for asthma therapy. (© 2022 Zhang et al.) |
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| معلومات مُعتمدة: | 81973329 National Natural Science Foundation of China; 21ZR1432700 Natural Science Foundation of Shanghai; 19X160010005 Shanghai Jiao Tong University |
| المشرفين على المادة: | 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor) EC 2.3.2.27 (AMFR protein, human) EC 2.3.2.27 (Receptors, Autocrine Motility Factor) |
| تواريخ الأحداث: | Date Created: 20220325 Date Completed: 20220418 Latest Revision: 20221102 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8961293 |
| DOI: | 10.1084/jem.20211828 |
| PMID: | 35333296 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1540-9538 |
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| DOI: | 10.1084/jem.20211828 |