دورية أكاديمية
أعرض في EDS

Structural biology of cell surface receptors implicated in Alzheimer's disease.

التفاصيل البيبلوغرافية
العنوان: Structural biology of cell surface receptors implicated in Alzheimer's disease.
المؤلفون: Hermans SJ; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Nero TL; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia., Morton CJ; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia., Gooi JH; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Crespi GAN; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Hancock NC; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Gao C; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia.; Present Address: Wren Therapeutics Ltd., Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW UK., Ishii K; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Markulić J; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia., Parker MW; Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010 Australia.; Structural Biology, St. Vincent's Institute of Medical Research, 9 Princes Street, Victoria 3065 Fitzroy, Australia.
المصدر: Biophysical reviews [Biophys Rev] 2021 Nov 18; Vol. 14 (1), pp. 233-255. Date of Electronic Publication: 2021 Nov 18 (Print Publication: 2022).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 101498573 Publication Model: eCollection Cited Medium: Print ISSN: 1867-2450 (Print) Linking ISSN: 18672450 NLM ISO Abbreviation: Biophys Rev Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Heidelberg : Springer
مستخلص: Alzheimer's disease is a common and devastating age-related disease with no effective disease-modifying treatments. Human genetics has implicated a wide range of cell surface receptors as playing a role in the disease, many of which are involved in the production or clearance of neurotoxins in the brain. Amyloid precursor protein, a membrane-bound signaling molecule, is at the very heart of the disease: hereditary mutations in its gene are associated with a greatly increased risk of getting the disease. A proteolytic breakdown product of amyloid precursor protein, the neurotoxic Aβ peptide, has been the target for many drug discovery efforts. Antibodies have been designed to target Aβ production with some success, although they have not proved efficacious in clinical trials with regards to cognitive benefits to date. Many of the recently identified genes associated with late-onset Alzheimer's disease risk are integral to the innate immune system. Some of these genes code for microglial proteins, such as the strongest genetic risk factor for the disease, namely APOE, and the cell surface receptors CD33 and TREM2 which are involved in clearance of the Aβ peptide from the brain. In this review, we show how structural biology has provided key insights into the normal functioning of these cell surface receptors and provided a framework for developing novel treatments to combat Alzheimer's disease.
Competing Interests: Conflict of interestWe have a collaboration and license agreement with Janssen Pharmaceuticals on some of our microglia work. Dr Chen Gao is now an employee of Wren Therapeutics Ltd.
(© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2021.)
References: Science. 1990 Oct 12;250(4978):279-82. (PMID: 2218531)
Brain Res. 1991 Nov 1;563(1-2):184-94. (PMID: 1786532)
Nanomedicine. 2014 May;10(4):871-8. (PMID: 24333588)
Nat Genet. 2011 May;43(5):436-41. (PMID: 21460841)
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):330-5. (PMID: 12506200)
Nat Immunol. 2015 Mar;16(3):229-36. (PMID: 25689443)
Curr Opin Neurol. 2021 Apr 1;34(2):228-236. (PMID: 33560670)
Biochemistry. 2009 Mar 10;48(9):1870-7. (PMID: 19216516)
J Biol Chem. 2009 Oct 16;284(42):28943-52. (PMID: 19596858)
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9758-63. (PMID: 23703910)
J Pept Sci. 2015 Jul;21(7):522-9. (PMID: 26018760)
J Cell Biol. 2003 Apr 14;161(1):41-54. (PMID: 12695498)
Nature. 1999 Jul 8;400(6740):173-7. (PMID: 10408445)
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Oct 1;63(Pt 10):819-24. (PMID: 17909280)
Alzheimers Dement. 2012;8(2):131-68. (PMID: 22404854)
J Exp Med. 2005 Feb 21;201(4):647-57. (PMID: 15728241)
J Biol Chem. 2013 Nov 15;288(46):33027-36. (PMID: 24078628)
Sci Rep. 2018 Apr 23;8(1):6412. (PMID: 29686315)
Cell. 2017 Jun 15;169(7):1276-1290.e17. (PMID: 28602351)
Cancers (Basel). 2021 Jun 28;13(13):. (PMID: 34203180)
EMBO J. 1996 Aug 1;15(15):3769-77. (PMID: 8670881)
J Neurosci. 2008 Jul 2;28(27):6787-93. (PMID: 18596154)
Acta Pharm Sin B. 2020 Aug;10(8):1347-1359. (PMID: 32963936)
Mol Neurodegener. 2020 Oct 8;15(1):57. (PMID: 33032659)
J Biol Chem. 2012 Aug 3;287(32):26840-53. (PMID: 22685292)
J Mol Biol. 2004 Jan 23;335(4):997-1006. (PMID: 14698294)
Front Aging Neurosci. 2016 Feb 23;8:31. (PMID: 26941642)
Nat Genet. 2011 May;43(5):429-35. (PMID: 21460840)
N Engl J Med. 2013 Jul 25;369(4):341-50. (PMID: 23883379)
J Mol Med (Berl). 2018 May;96(5):361-371. (PMID: 29516132)
Sci Rep. 2016 Dec 20;6:39374. (PMID: 27996029)
EMBO Mol Med. 2016 Jun 01;8(6):595-608. (PMID: 27025652)
Neuron. 2018 Mar 7;97(5):1023-1031.e7. (PMID: 29518356)
Mol Neurobiol. 2015 Feb;51(1):1-7. (PMID: 24733588)
J Med Chem. 2019 Apr 25;62(8):4120-4130. (PMID: 30933499)
Front Aging Neurosci. 2015 Jul 20;7:124. (PMID: 26257642)
Biochemistry. 1998 Aug 4;37(31):11064-77. (PMID: 9693002)
Nature. 1987 Feb 19-25;325(6106):733-6. (PMID: 2881207)
Biol Psychiatry. 2018 Feb 15;83(4):311-319. (PMID: 28967385)
Science. 2014 May 16;344(6185):1249783. (PMID: 24833397)
Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):. (PMID: 33446504)
Annu Rev Immunol. 2020 Apr 26;38:365-395. (PMID: 31986070)
Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5381-6. (PMID: 20212142)
Nature. 2014 Nov 13;515(7526):274-8. (PMID: 25307057)
Nat Med. 2000 Aug;6(8):916-9. (PMID: 10932230)
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4109-12. (PMID: 9108113)
Nat Commun. 2021 Jun 7;12(1):3416. (PMID: 34099706)
Nature. 2019 Jan;565(7738):192-197. (PMID: 30598546)
Lancet Neurol. 2013 Apr;12(4):357-67. (PMID: 23477989)
Cell. 2017 Dec 14;171(7):1638-1648.e7. (PMID: 29224781)
Trends Pharmacol Sci. 2016 May;37(5):390-411. (PMID: 26837733)
Hum Mol Genet. 2014 Nov 1;23(21):5838-46. (PMID: 24899047)
Neuroscientist. 2021 Jun 18;:10738584211024531. (PMID: 34142603)
Nature. 2016 Aug 31;537(7618):50-6. (PMID: 27582220)
Nat Chem. 2009 Jul;1(4):326-31. (PMID: 20703363)
J Biol Chem. 1995 Dec 29;270(52):30853-6. (PMID: 8537337)
Alzheimers Res Ther. 2013 Oct 17;5(5):48. (PMID: 24131566)
Neuroscientist. 2011 Apr;17(2):163-73. (PMID: 21330304)
Science. 2002 Jul 19;297(5580):353-6. (PMID: 12130773)
Science. 1992 Apr 10;256(5054):184-5. (PMID: 1566067)
J Clin Invest. 1985 Feb;75(2):746-53. (PMID: 3855866)
Blood. 2005 Feb 1;105(3):1295-302. (PMID: 15454492)
J Mol Biol. 2001 Oct 5;312(5):1103-19. (PMID: 11580253)
J Neurochem. 2007 Jun;101(5):1172-84. (PMID: 17286590)
iScience. 2019 Sep 27;19:110-118. (PMID: 31369984)
J Phys Chem B. 2012 Apr 5;116(13):4043-55. (PMID: 22409719)
Immunity. 2017 Sep 19;47(3):566-581.e9. (PMID: 28930663)
Alzheimers Res Ther. 2014 Jun 02;6(3):31. (PMID: 25024748)
Cell. 1989 Apr 7;57(1):115-26. (PMID: 2649245)
Nature. 2002 Apr 4;416(6880):535-9. (PMID: 11932745)
Nature. 2000 Dec 21-28;408(6815):982-5. (PMID: 11140686)
J Biol Chem. 1996 May 10;271(19):11339-46. (PMID: 8626687)
Blood. 2007 Feb 1;109(3):1061-8. (PMID: 17008544)
J Biol Chem. 2011 Nov 4;286(44):38570-38582. (PMID: 21914797)
Science. 1993 Aug 13;261(5123):921-3. (PMID: 8346443)
Nat Rev Neurol. 2021 Jun;17(6):328. (PMID: 33986528)
Neuron. 2016 May 18;90(4):724-39. (PMID: 27196974)
Nat Genet. 2017 Sep;49(9):1373-1384. (PMID: 28714976)
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13407-12. (PMID: 9811813)
J Cell Sci. 2013 Nov 1;126(Pt 21):4856-61. (PMID: 23986479)
J Biol Chem. 2014 May 2;289(18):12931-45. (PMID: 24644280)
Science. 2017 Oct 6;358(6359):116-119. (PMID: 28882996)
J Neurosci. 2012 Aug 1;32(31):10674-85. (PMID: 22855816)
Neurobiol Dis. 2004 Feb;15(1):11-20. (PMID: 14751766)
J Neurosci. 1999 Mar 1;19(5):1717-27. (PMID: 10024358)
J Struct Biol. 2000 Jun;130(2-3):184-208. (PMID: 10940225)
Eur Biophys J. 2008 Mar;37(3):269-79. (PMID: 18030462)
Nature. 2021 Aug;596(7873):583-589. (PMID: 34265844)
Alzheimers Dement. 2020 Oct 8;:. (PMID: 33090700)
Nature. 2018 Jul;559(7715):S4-S7. (PMID: 30046080)
J Neurosci. 2004 Jul 7;24(27):6144-51. (PMID: 15240806)
Acta Pharmacol Sin. 2017 Sep;38(9):1205-1235. (PMID: 28713158)
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8850-5. (PMID: 11438712)
J Neurochem. 2001 Mar;76(5):1411-20. (PMID: 11238726)
Neurobiol Aging. 2006 Sep;27(9):1224-38. (PMID: 16122841)
Neurotherapeutics. 2010 Oct;7(4):354-65. (PMID: 20880500)
Science. 2019 Feb 15;363(6428):. (PMID: 30630874)
Expert Rev Mol Med. 2016 Jun 30;18:e13. (PMID: 27357999)
Mol Cell. 2004 Aug 13;15(3):343-53. (PMID: 15304215)
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2023-8. (PMID: 12566568)
J Biol Chem. 2017 Jan 20;292(3):1029-1037. (PMID: 27920204)
Brain Res. 2015 Aug 18;1617:18-27. (PMID: 25110235)
J Phys Chem B. 2018 Jan 11;122(1):144-153. (PMID: 29220175)
Biochemistry. 2010 Feb 16;49(6):1259-67. (PMID: 20050679)
Front Aging Neurosci. 2017 Jun 08;9:176. (PMID: 28642697)
J Immunol. 1995 Jan 15;154(2):944-53. (PMID: 7814894)
Nat Struct Mol Biol. 2020 Dec;27(12):1125-1133. (PMID: 32989305)
J Neurosci. 1994 Apr;14(4):2117-27. (PMID: 8158260)
Curr Protoc Neurosci. 2019 Sep;89(1):e81. (PMID: 31532917)
Biochemistry. 1993 May 11;32(18):4693-7. (PMID: 8490014)
J Biol Chem. 1996 Aug 2;271(31):18803-9. (PMID: 8702538)
Elife. 2016 Dec 20;5:. (PMID: 27995897)
Eur J Immunol. 1999 Nov;29(11):3440-9. (PMID: 10556798)
JAMA Neurol. 2014 Apr;71(4):505-8. (PMID: 24493463)
EMBO J. 2020 Oct 15;39(20):e104247. (PMID: 32830336)
N Engl J Med. 2013 Jan 10;368(2):107-16. (PMID: 23150908)
J Biol Chem. 2003 May 9;278(19):17401-7. (PMID: 12611883)
Sci Rep. 2013;3:1302. (PMID: 23416764)
J Med Chem. 2016 Apr 14;59(7):3231-48. (PMID: 26937601)
Cell Mol Life Sci. 2012 Apr;69(8):1353-75. (PMID: 22105709)
Biochemistry. 2010 Nov 9;49(44):9533-41. (PMID: 20923231)
Mol Immunol. 2003 Dec;40(9):585-93. (PMID: 14597161)
EMBO J. 1997 Oct 15;16(20):6141-50. (PMID: 9321393)
Genomics. 1994 Sep 15;23(2):504-7. (PMID: 7835906)
Immunol Rev. 2020 Sep;297(1):225-246. (PMID: 32588460)
Alzheimers Dement. 2014 Oct;10(5 Suppl):S411-9. (PMID: 24530026)
J Biol Chem. 2000 Jun 2;275(22):16941-7. (PMID: 10747968)
Mol Neurodegener. 2012 Aug 14;7:39. (PMID: 22892055)
Blood. 2000 Jul 15;96(2):483-90. (PMID: 10887109)
J Mol Biol. 2004 Jan 2;335(1):247-60. (PMID: 14659754)
Q Rev Biophys. 2006 Feb;39(1):1-55. (PMID: 16772049)
Mol Psychiatry. 2012 Dec;17(12):1316-27. (PMID: 22005930)
Biochemistry. 1990 Oct 30;29(43):10018-22. (PMID: 2125487)
Biophys J. 2008 Apr 1;94(7):2752-66. (PMID: 18065467)
Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6364-9. (PMID: 11959919)
J Neurosci. 2012 Jul 11;32(28):9677-89. (PMID: 22787053)
PLoS One. 2017 Oct 24;12(10):e0186636. (PMID: 29065138)
Cell Adh Migr. 2010 Apr-Jun;4(2):268-72. (PMID: 20400860)
EMBO Mol Med. 2020 Apr 7;12(4):e11227. (PMID: 32154671)
Acta Neuropathol. 2015 Jan;129(1):1-19. (PMID: 25287911)
Eur J Biochem. 2002 Nov;269(22):5642-8. (PMID: 12423364)
Ageing Res Rev. 2014 Mar;14:19-30. (PMID: 24503004)
PLoS Comput Biol. 2018 Jun 22;14(6):e1006165. (PMID: 29933361)
Prog Neurobiol. 2017 Sep;156:189-213. (PMID: 28587768)
Trends Neurosci. 2001 Apr;24(4):219-24. (PMID: 11250006)
J Am Chem Soc. 2011 May 4;133(17):6505-8. (PMID: 21486030)
Neuron. 2019 Sep 4;103(5):820-835.e7. (PMID: 31301936)
Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):. (PMID: 33431654)
Sci Transl Med. 2016 Dec 14;8(369):369ra178. (PMID: 27974666)
N Engl J Med. 2013 Jan 10;368(2):117-27. (PMID: 23150934)
Protein Expr Purif. 2021 Mar;179:105796. (PMID: 33221505)
Mol Neurodegener. 2016 Jan 12;11:3. (PMID: 26754172)
Nat Rev Drug Discov. 2012 Sep;11(9):657-60. (PMID: 22935790)
J Alzheimers Dis. 2012;28(1):49-69. (PMID: 21955818)
J Leukoc Biol. 2008 Jan;83(1):200-11. (PMID: 17947393)
Nat Commun. 2019 Oct 29;10(1):4760. (PMID: 31664019)
J Mol Biol. 2007 Mar 16;367(1):148-61. (PMID: 17239395)
J Biol Chem. 2018 Aug 10;293(32):12634-12646. (PMID: 29794134)
Front Pharmacol. 2019 Aug 23;10:840. (PMID: 31507408)
Nat Rev Neurol. 2021 Mar;17(3):157-172. (PMID: 33318676)
Structure. 2021 Nov 4;29(11):1241-1252.e5. (PMID: 34233201)
Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):. (PMID: 34187891)
Biochem Biophys Res Commun. 2011 Jul 29;411(2):312-6. (PMID: 21726530)
Nat Genet. 2019 Mar;51(3):414-430. (PMID: 30820047)
Neuron. 2016 Jul 20;91(2):328-40. (PMID: 27477018)
Sci Transl Med. 2014 Jul 2;6(243):243ra86. (PMID: 24990881)
J Biol Chem. 2018 Oct 5;293(40):15419-15428. (PMID: 30143530)
Sci Rep. 2015 Apr 16;5:9649. (PMID: 25880481)
J Biol Chem. 1999 Apr 23;274(17):11505-12. (PMID: 10206955)
J Biol Chem. 2015 Oct 23;290(43):26033-42. (PMID: 26374897)
Alzheimers Dement. 2017 Apr;13(4):381-387. (PMID: 27520774)
J Mol Biol. 2012 Aug 24;421(4-5):525-36. (PMID: 22197375)
Front Mol Neurosci. 2017 Jan 31;10:3. (PMID: 28197070)
Mol Neurobiol. 2016 Apr;53(3):1672-1678. (PMID: 25691454)
Expert Opin Investig Drugs. 2018 Apr;27(4):339-348. (PMID: 29534618)
Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18349-54. (PMID: 19015532)
Hum Immunol. 2013 Jun;74(6):730-7. (PMID: 23459077)
J Neurochem. 2012 Jan;120 Suppl 1:99-108. (PMID: 22150401)
J Leukoc Biol. 2006 Jan;79(1):46-58. (PMID: 16380601)
J Alzheimers Dis. 2010;22(3):741-63. (PMID: 20847424)
Am J Epidemiol. 2002 Sep 1;156(5):445-53. (PMID: 12196314)
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):452-5. (PMID: 8552659)
J Biol Chem. 2002 Oct 4;277(40):36948-54. (PMID: 12149256)
J Biol Chem. 2015 Oct 23;290(43):26043-50. (PMID: 26374899)
Cell Mol Neurobiol. 2018 Jan;38(1):53-71. (PMID: 28534246)
Biochemistry. 2011 Apr 5;50(13):2550-8. (PMID: 21322570)
Mol Cell Biol. 1996 Nov;16(11):6229-41. (PMID: 8887653)
Trends Pharmacol Sci. 1991 Oct;12(10):383-8. (PMID: 1763432)
J Mol Biol. 2012 Feb 24;416(3):438-52. (PMID: 22245578)
Traffic. 2008 Feb;9(2):267-79. (PMID: 18062779)
Expert Opin Investig Drugs. 2020 Sep;29(9):919-933. (PMID: 32657175)
Nature. 1993 Mar 4;362(6415):75-9. (PMID: 8446172)
Nat Struct Biol. 1999 Apr;6(4):327-31. (PMID: 10201399)
J Neuroimmunol. 2007 Mar;184(1-2):92-9. (PMID: 17239445)
Int J Mol Sci. 2021 Jun 14;22(12):. (PMID: 34198582)
Cell. 2013 Sep 12;154(6):1257-68. (PMID: 24034249)
J Struct Biol. 2000 Jun;130(2-3):130-41. (PMID: 10940221)
J Neurochem. 1999 Feb;72(2):549-56. (PMID: 9930726)
J Clin Pharmacol. 2021 Jan;61(1):7-17. (PMID: 32875599)
J Biol Chem. 1989 May 25;264(15):9094-101. (PMID: 2498325)
Clin Neuropharmacol. 2013 Jan-Feb;36(1):14-23. (PMID: 23334070)
Nat Rev Immunol. 2007 Apr;7(4):255-66. (PMID: 17380156)
Acta Neuropathol. 2016 Jun;131(6):925-33. (PMID: 26754641)
Science. 2000 Oct 6;290(5489):150-3. (PMID: 11021803)
EMBO Rep. 2008 Nov;9(11):1134-40. (PMID: 18833287)
J Neurosci. 2012 Feb 22;32(8):2696-702. (PMID: 22357853)
J Biol Chem. 2001 Sep 7;276(36):33923-9. (PMID: 11438549)
Nat Commun. 2021 Jan 29;12(1):710. (PMID: 33514714)
Transplantation. 1992 Nov;54(5):829-33. (PMID: 1440849)
J Biol Chem. 2003 Jul 18;278(29):26687-94. (PMID: 12736250)
فهرسة مساهمة: Keywords: Alzheimer’s disease; Antibodies; Cell surface receptors; Neuroinflammation; Structural biology; X-ray crystallography
تواريخ الأحداث: Date Created: 20220328 Latest Revision: 20221119
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8921391
DOI: 10.1007/s12551-021-00903-9
PMID: 35340615
قاعدة البيانات: MEDLINE
الوصف
تدمد:1867-2450
DOI:10.1007/s12551-021-00903-9