دورية أكاديمية
أعرض في EDS

Plasma advanced glycation end products and soluble receptor for advanced glycation end products as indicators of sterol content in human carotid atherosclerotic plaques.

التفاصيل البيبلوغرافية
العنوان: Plasma advanced glycation end products and soluble receptor for advanced glycation end products as indicators of sterol content in human carotid atherosclerotic plaques.
المؤلفون: Pinto RS; Laboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.; 130241Universidade Santa Cecília - UNISANTA, Santos, Brazil., Ferreira GS; Laboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Silvestre GCR; Laboratório de Anatomia e Cirurgia Vascular (LIM 02), 117265Hospital das Clinicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Santana MFM; Laboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Nunes VS; Laboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Ledesma L; 125291Universidade Nove de Julho, São Paulo, Brazil., Pinto PR; Laboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., de Assis SIS; Laboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Machado UF; Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., da Silva ES; Laboratório de Anatomia e Cirurgia Vascular (LIM 02), 117265Hospital das Clinicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Passarelli M; Laboratório de Lípides (LIM10), Hospital das Clinicas (HCFMUSP), 117265Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.; Programa de Pós-Graduação em Medicina, Universidade Nove de Julho, São Paulo, Brazil.
المصدر: Diabetes & vascular disease research [Diab Vasc Dis Res] 2022 Jan-Feb; Vol. 19 (1), pp. 14791641221085269.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Sage Publications Country of Publication: England NLM ID: 101234011 Publication Model: Print Cited Medium: Internet ISSN: 1752-8984 (Electronic) Linking ISSN: 14791641 NLM ISO Abbreviation: Diab Vasc Dis Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2009- : London : Sage Publications
Original Publication: Edgbaston, Birmingham, UK : Sherborne Gibbs, c2005-
مواضيع طبية MeSH: Atherosclerosis* , Plaque, Atherosclerotic*, Glycation End Products, Advanced ; Humans ; Receptor for Advanced Glycation End Products ; Sterols
مستخلص: Advanced glycation end products (AGEs) are independently related to cardiovascular disease (CVD) and favor cholesterol and oxysterol accumulation in macrophage foam cells. Soluble RAGE (sRAGE) impairs cellular AGE signaling alleviating the deleterious effects of AGE in atherogenesis. The association between plasma AGEs and sRAGE with the content of cholesterol, markers of cholesterol synthesis and absorption, and oxysterols in atherosclerotic plaques was evaluated in subjects undergoing carotid endarterectomy.Plasma and carotid plaques were obtained from symptomatic ( n = 23) and asymptomatic subjects ( n = 40). Lipids from plaques were extracted and sterols (oxysterols, cholesterol, desmosterol, lathosterol, sitosterol, and campesterol) were determined by using gas chromatography/mass spectrometry. Plasma total AGEs and pentosidine were measured by using fluorimetry and sRAGE by using ELISA.In symptomatic subjects´ atherosclerotic plaques, an increased amount of cholesterol (3x) and oxysterols [7 α-hydroxycholesterol (1.4x); 7 β-hydroxycholesterol (1.2x); 25-hydroxycholesterol (1.3x); 24-hydroxycholesterol (2.7x), and 27-hydroxycholesterol, (1.15x)], with exception to 7 ketocholesterol, were found in comparison to asymptomatic individuals. Plasma total AGEs and pentosidine significantly and positively correlated to sterols accumulated in the atherosclerotic lesion, including cholesterol, desmosterol, campesterol, sitosterol, and oxysterols. On the other hand, sRAGE inversely correlated to total AGEs and pentosidine in plasma, and with major species of oxysterols, cholesterol, and markers of cholesterol synthesis and absorption in the atherosclerotic lesion. In multiple regression analyses, it was observed a significant inverse correlation between sRAGE and 24-hydroxycholesterol and desmosterol, and a positive significant correlation between pentosidine and 24-hydroxycholesterol, 27-hydroxycholesterol, and campesterol.In conclusion, the plasma concentration of AGEs and sRAGE is a tool to predict the accumulation of sterols in atherosclerotic lesions in symptomatic and asymptomatic individuals, helping to prevent and improve the management of acute cardiovascular complications.
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فهرسة مساهمة: Keywords: Advanced glycation end product; atherosclerosis; carotid endarterectomy; oxysterols; soluble RAGE
المشرفين على المادة: 0 (AGER protein, human)
0 (Glycation End Products, Advanced)
0 (Receptor for Advanced Glycation End Products)
0 (Sterols)
تواريخ الأحداث: Date Created: 20220328 Date Completed: 20220404 Latest Revision: 20220830
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8965288
DOI: 10.1177/14791641221085269
PMID: 35343275
قاعدة البيانات: MEDLINE
الوصف
تدمد:1752-8984
DOI:10.1177/14791641221085269