دورية أكاديمية
أعرض في EDS

Efficacy of Lauromacrogol Injection for Ablation of Benign Predominantly Cystic Thyroid Nodules and Related Factors: A Prospective Study.

التفاصيل البيبلوغرافية
العنوان: Efficacy of Lauromacrogol Injection for Ablation of Benign Predominantly Cystic Thyroid Nodules and Related Factors: A Prospective Study.
المؤلفون: Dong YJ; Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Liu ZH; Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Zhou JQ; Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. zhousu30@126.com., Zhan WW; Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
المصدر: Korean journal of radiology [Korean J Radiol] 2022 Apr; Vol. 23 (4), pp. 479-487.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Korean Society of Radiology Country of Publication: Korea (South) NLM ID: 100956096 Publication Model: Print Cited Medium: Internet ISSN: 2005-8330 (Electronic) Linking ISSN: 12296929 NLM ISO Abbreviation: Korean J Radiol Subsets: MEDLINE
أسماء مطبوعة: Publication: October 2008-: Seoul, Korea : Korean Society of Radiology
Original Publication: Seoul, Korea : Korean Radiological Society, 2000-August 2008.
مواضيع طبية MeSH: Radiofrequency Ablation* , Thyroid Nodule*/diagnostic imaging , Thyroid Nodule*/surgery, Female ; Humans ; Male ; Polidocanol ; Prospective Studies ; Treatment Outcome
مستخلص: Objective: To prospectively evaluate the efficacy of lauromacrogol injection for ablation (LIA) of benign predominantly cystic thyroid nodules and its related factors.
Materials and Methods: A total of 142 benign predominantly cystic thyroid nodules (median volume, 12.5 mL; range, 0.4-156 mL) in 137 patients (male:female sex ratio, 36:101; mean age ± standard deviation [SD], 49 ± 13 years) were treated with LIA after being confirmed as benign via cytology. The volume reduction rate (VRR) of the nodules and cosmetic score were evaluated during follow-up at 1, 3, and 6 months after treatment and every 6 months thereafter. A VRR of ≥ 50% at the 12-month follow-up was considered to indicate effective treatment. The associations between the clinical factors and nodular ultrasound features, including the initial nodule volume, proportion of solid components, vascularity grade and ineffective treatment (VRR of < 50% at the 12-month follow-up), and regrowth were analyzed.
Results: All patients completed follow-up for at least 12 months. The average ± SD follow-up period was 32 ± 11 months (range, 12-54 months). The effective treatment rate was 73.2% (104/142), while the regrowth rate was 12.0% (17/142) at the last follow-up. Grade 2-3 intranodular vascularity in the solid components of the nodules was the only independent factor associated with ineffective treatment, with an odds ratio (reference category, grade 0-1) of 3.054 (95% confidence interval, 1.148-8.127) ( p = 0.025).
Conclusion: LIA is an effective treatment for predominantly cystic thyroid nodules. Grade 2-3 intranodular vascularity in the solid components of nodules is the only independent risk factor for ineffective LIA.
Competing Interests: The authors have no potential conflicts of interest to disclose.
(Copyright © 2022 The Korean Society of Radiology.)
References: Int J Hyperthermia. 2019;36(1):376-382. (PMID: 30909759)
Thyroid. 1996 Oct;6(5):403-8. (PMID: 8936663)
J Clin Endocrinol Metab. 2013 Oct;98(10):3949-57. (PMID: 23956350)
Korean J Radiol. 2019 Apr;20(4):609-620. (PMID: 30887743)
Thyroid. 1999 Aug;9(8):763-7. (PMID: 10482367)
United European Gastroenterol J. 2018 Jul;6(6):919-925. (PMID: 30023070)
Thyroid. 2016 Jan;26(1):1-133. (PMID: 26462967)
Korean J Radiol. 2018 Jul-Aug;19(4):632-655. (PMID: 29962870)
Eur Radiol. 2012 Jul;22(7):1573-8. (PMID: 22437920)
Eur J Radiol. 2012 May;81(5):905-10. (PMID: 21388767)
AJR Am J Roentgenol. 2000 Jan;174(1):213-6. (PMID: 10628481)
Thyroid. 2002 Sep;12(9):815-21. (PMID: 12481948)
Gastrointest Endosc. 2017 Nov;86(5):872-880. (PMID: 28365355)
AJR Am J Roentgenol. 2003 Jun;180(6):1723-6. (PMID: 12760950)
Gastrointest Endosc. 2018 May;87(5):1367. (PMID: 29655441)
Korean J Radiol. 2012 Mar-Apr;13(2):117-25. (PMID: 22438678)
AJR Am J Roentgenol. 2010 Apr;194(4):1137-42. (PMID: 20308523)
Endocr Pract. 2004 May-Jun;10(3):269-75. (PMID: 15310546)
Endocr J. 2005 Aug;52(4):455-62. (PMID: 16127215)
Thyroid. 2019 May;29(5):611-618. (PMID: 30803397)
Int Urol Nephrol. 2015 Apr;47(4):603-7. (PMID: 25778818)
J Clin Endocrinol Metab. 1994 Mar;78(3):800-2. (PMID: 8126160)
Radiology. 2013 Oct;269(1):293-300. (PMID: 23616630)
Phlebology. 2018 Apr;33(3):150-162. (PMID: 28166694)
Ultrasound Med Biol. 2018 Jan;44(1):14-36. (PMID: 29126752)
Korean J Radiol. 2015 Nov-Dec;16(6):1332-40. (PMID: 26576124)
Clin Radiol. 2015 Jan;70(1):42-7. (PMID: 25443776)
Pak J Pharm Sci. 2015 Mar;28(2 Suppl):697-700. (PMID: 25796160)
Ann Ital Chir. 2016;87:192-7. (PMID: 27179294)
Front Pharmacol. 2019 May 08;10:478. (PMID: 31139077)
فهرسة مساهمة: Keywords: Ablation; Lauromacrogol; Predominantly cystic nodule; Thyroid; Ultrasound
المشرفين على المادة: 0AWH8BFG9A (Polidocanol)
تواريخ الأحداث: Date Created: 20220328 Date Completed: 20220404 Latest Revision: 20220529
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8961015
DOI: 10.3348/kjr.2020.1205
PMID: 35345062
قاعدة البيانات: MEDLINE
الوصف
تدمد:2005-8330
DOI:10.3348/kjr.2020.1205