دورية أكاديمية
أعرض في EDS

Nyssorhynchus darlingi genome-wide studies related to microgeographic dispersion and blood-seeking behavior.

التفاصيل البيبلوغرافية
العنوان: Nyssorhynchus darlingi genome-wide studies related to microgeographic dispersion and blood-seeking behavior.
المؤلفون: Alvarez MVN; Sao Paulo State University (UNESP), Botucatu, 18618-689, Brazil., Alonso DP; Sao Paulo State University (UNESP), Botucatu, 18618-689, Brazil., Kadri SM; Sao Paulo State University (UNESP), Botucatu, 18618-689, Brazil., Rufalco-Moutinho P; Nucleo de Medicina Tropical, Universidade de Brasília, Brasília, Brazil., Bernardes IAF; Sao Paulo State University (UNESP), Botucatu, 18618-689, Brazil., de Mello ACF; Sao Paulo State University (UNESP), Botucatu, 18618-689, Brazil., Souto AC; Sao Paulo State University (UNESP), Botucatu, 18618-689, Brazil., Carrasco-Escobar G; Laboratorio ICEMR-Amazonia, Laboratorios de Investigación Y Desarrollo, Facultad de Ciencias Y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru.; Facultad de Salud Pública, Universidad Peruana Cayetano Heredia, Lima, Peru., Moreno M; Laboratorio ICEMR-Amazonia, Laboratorios de Investigación Y Desarrollo, Facultad de Ciencias Y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru.; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK., Gamboa D; Laboratorio ICEMR-Amazonia, Laboratorios de Investigación Y Desarrollo, Facultad de Ciencias Y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru.; Departamento de Ciencias Celulares Y Moleculares, Facultad de Ciencias Y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.; Instituto de Medicina Tropical Alexander Von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru., Vinetz JM; Laboratorio ICEMR-Amazonia, Laboratorios de Investigación Y Desarrollo, Facultad de Ciencias Y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru.; Instituto de Medicina Tropical Alexander Von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.; Section of Infectious Diseases, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA., Conn JE; Wadsworth Center, New York State Department of Health, Albany, NY, USA.; Department of Biomedical Sciences, School of Public Health, State University of New York at Albany, Albany, NY, USA., Ribolla PEM; Sao Paulo State University (UNESP), Botucatu, 18618-689, Brazil. p.ribolla@unesp.br.
المصدر: Parasites & vectors [Parasit Vectors] 2022 Mar 28; Vol. 15 (1), pp. 106. Date of Electronic Publication: 2022 Mar 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101462774 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-3305 (Electronic) Linking ISSN: 17563305 NLM ISO Abbreviation: Parasit Vectors Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central
مواضيع طبية MeSH: Anopheles*/genetics , Malaria*, Animals ; Disease Vectors ; Female ; Genome-Wide Association Study ; Mosquito Vectors/genetics
مستخلص: Background: In Brazil, malaria is concentrated in the Amazon Basin, where more than 99% of the annual cases are reported. The main goal of this study was to investigate the population structure and genetic association of the biting behavior of Nyssorhynchus (also known as Anopheles) darlingi, the major malaria vector in the Amazon region of Brazil, using low-coverage genomic sequencing data.
Methods: Samples were collected in the municipality of Mâncio Lima, Acre state, Brazil between 2016 and 2017. Different approaches using genotype imputation and no gene imputation for data treatment and low-coverage sequencing genotyping were performed. After the samples were genotyped, population stratification analysis was performed.
Results: Weak but statistically significant stratification signatures were identified between subpopulations separated by distances of approximately 2-3 km. Genome-wide association studies (GWAS) were performed to compare indoor/outdoor biting behavior and blood-seeking at dusk/dawn. A statistically significant association was observed between biting behavior and single nucleotide polymorphism (SNP) markers adjacent to the gene associated with cytochrome P450 (CYP) 4H14, which is associated with insecticide resistance. A statistically significant association between blood-seeking periodicity and SNP markers adjacent to genes associated with the circadian cycle was also observed.
Conclusion: The data presented here suggest that low-coverage whole-genome sequencing with adequate processing is a powerful tool to genetically characterize vector populations at a microgeographic scale in malaria transmission areas, as well as for use in GWAS. Female mosquitoes entering houses to take a blood meal may be related to a specific CYP4H14 allele, and female timing of blood-seeking is related to circadian rhythm genes.
(© 2022. The Author(s).)
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معلومات مُعتمدة: U19 AI089681 United States AI NIAID NIH HHS; D43 TW007120 United States TW FIC NIH HHS
تواريخ الأحداث: Date Created: 20220329 Date Completed: 20220330 Latest Revision: 20240512
رمز التحديث: 20240512
مُعرف محوري في PubMed: PMC8961893
DOI: 10.1186/s13071-022-05219-5
PMID: 35346342
قاعدة البيانات: MEDLINE
الوصف
تدمد:1756-3305
DOI:10.1186/s13071-022-05219-5