دورية أكاديمية
Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet.
| العنوان: | Cardiometabolic effects of DOCA-salt in male C57BL/6J mice are variably dependent on sodium and nonsodium components of diet. |
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| المؤلفون: | Patil CN; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Ritter ML; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Wackman KK; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Oliveira V; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Balapattabi K; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Grobe CC; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin., Brozoski DT; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Reho JJ; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, Wisconsin., Nakagawa P; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Mouradian GC Jr; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Kriegel AJ; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin., Kwitek AE; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.; Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin., Hodges MR; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Segar JL; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin., Sigmund CD; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.; Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin., Grobe JL; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Center of Systems Molecular Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin.; Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin.; Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin. |
| المصدر: | American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2022 Jun 01; Vol. 322 (6), pp. R467-R485. Date of Electronic Publication: 2022 Mar 29. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, Md. : American Physiological Society |
| مواضيع طبية MeSH: | Desoxycorticosterone Acetate*/pharmacology , Hypertension*/metabolism, Animals ; Aquaporin 2 ; Blood Pressure/physiology ; Desoxycorticosterone/pharmacology ; Diet ; Male ; Mice ; Mice, Inbred C57BL ; Renin/metabolism ; Sodium/metabolism |
| مستخلص: | Hypertension characterized by low circulating renin activity accounts for roughly 25%-30% of primary hypertension in humans and can be modeled experimentally via deoxycorticosterone acetate (DOCA)-salt treatment. In this model, phenotypes develop in progressive phases, although the timelines and relative contributions of various mechanisms to phenotype development can be distinct between laboratories. To explore interactions among environmental influences such as diet formulation and dietary sodium (Na) content on phenotype development in the DOCA-salt paradigm, we examined an array of cardiometabolic endpoints in young adult male C57BL/6J mice during sham or DOCA-salt treatments when mice were maintained on several common, commercially available laboratory rodent "chow" diets including PicoLab 5L0D (0.39% Na), Envigo 7913 (0.31% Na), Envigo 2920x (0.15% Na), or a customized version of Envigo 2920x (0.4% Na). Energy balance (weight gain, food intake, digestive efficiency, and energy efficiency), fluid and electrolyte homeostasis (fluid intake, Na intake, fecal Na content, hydration, and fluid compartmentalization), renal functions (urine production rate, glomerular filtration rate, urine Na excretion, renal expression of renin, vasopressin receptors, aquaporin-2 and relationships among markers of vasopressin release, aquaporin-2 shedding, and urine osmolality), and blood pressure, all exhibited changes that were subject to interactions between diet and DOCA-salt. Interestingly, some of these phenotypes, including blood pressure and hydration, were dependent on nonsodium dietary components, as Na-matched diets resulted in distinct phenotype development. These findings provide a broad and robust illustration of an environment × treatment interaction that impacts the use and interpretation of a common rodent model of low-renin hypertension. |
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| معلومات مُعتمدة: | K01 HL153101 United States HL NHLBI NIH HHS; T32 HL007852 United States HL NHLBI NIH HHS; R01 HL134850 United States HL NHLBI NIH HHS; P30 ES005605 United States ES NIEHS NIH HHS; R35 HL144807 United States HL NHLBI NIH HHS; P01 HL084207 United States HL NHLBI NIH HHS; R01 HL122358 United States HL NHLBI NIH HHS; UL1 TR001436 United States TR NCATS NIH HHS |
| فهرسة مساهمة: | Keywords: deoxycorticosterone; diet; fluid; hypertension; metabolism |
| المشرفين على المادة: | 0 (Aquaporin 2) 40GP35YQ49 (Desoxycorticosterone) 6E0A168OB8 (Desoxycorticosterone Acetate) 9NEZ333N27 (Sodium) EC 3.4.23.15 (Renin) |
| تواريخ الأحداث: | Date Created: 20220329 Date Completed: 20220428 Latest Revision: 20240214 |
| رمز التحديث: | 20240214 |
| مُعرف محوري في PubMed: | PMC9054347 |
| DOI: | 10.1152/ajpregu.00017.2022 |
| PMID: | 35348007 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1490 |
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| DOI: | 10.1152/ajpregu.00017.2022 |