دورية أكاديمية
Neurodevelopment in Children Exposed to Zika in utero : Clinical and Molecular Aspects.
العنوان: | Neurodevelopment in Children Exposed to Zika in utero : Clinical and Molecular Aspects. |
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المؤلفون: | Schuler-Faccini L; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.; Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil., Del Campo M; Department of Pediatrics, School of Medicine, University of California San Diego, and Rady Children's Hospital San Diego, San Diego, CA, United States., García-Alix A; Neonatal Neurology, NeNe Foundation, Madrid, Spain., Ventura LO; Department of Ophthalmology, Fundação Altino Ventura, FAV, Recife, Brazil., Boquett JA; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil., van der Linden V; Hospital Barão de Lucena, Recife, Brazil., Pessoa A; Hospital Infantil Albert Sabin, Fortaleza, Brazil.; Universidade Estadual do Ceará, Fortaleza, Brazil., van der Linden Júnior H; Dr. Henrique Santillo Rehabilitation and Readaptation Center, Goiânia, Brazil., Ventura CV; Department of Ophthalmology, Fundação Altino Ventura, FAV, Recife, Brazil., Leal MC; Universidade Federal de Pernambuco, UFPE, Recife, Brazil., Kowalski TW; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.; CESUCA-Centro Universitário, Cachoeirinha, Brazil., Rodrigues Gerzson L; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil., Skilhan de Almeida C; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil., Santi L; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.; Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil., Beys-da-Silva WO; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.; Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil., Quincozes-Santos A; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil., Guimarães JA; Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil., Garcez PP; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Gomes JDA; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil., Vianna FSL; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.; Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil., Anjos da Silva A; School of Medicine, Graduate Program in Medical Sciences-Universidade do Vale do Taquari-UNIVATES, Lajeado, Brazil.; School of Medicine, Universidade do Vale do Rio dos Sinos-UNISINOS, São Leopoldo, Brazil., Fraga LR; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.; Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil., Vieira Sanseverino MT; Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil.; Pontifícia Universidade Católica do Rio Grande do Sul, PUCRS, Porto Alegre, Brazil., Muotri AR; Department of Pediatrics, School of Medicine, University of California San Diego, and Rady Children's Hospital San Diego, San Diego, CA, United States., Lopes da Rosa R; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil., Abeche AM; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.; Medical Genetics Service, Hospital de Clinicas de Porto Alegre, HCPA, Porto Alegre, Brazil., Marcolongo-Pereira C; Centro Universitário do Estírito Santo, UNESC, Colatina, Brazil., Souza DO; Universidade Federal do Rio Grande do Sul, UFRGS, Porto Alegre, Brazil. |
المصدر: | Frontiers in genetics [Front Genet] 2022 Mar 08; Vol. 13, pp. 758715. Date of Electronic Publication: 2022 Mar 08 (Print Publication: 2022). |
نوع المنشور: | Journal Article; Review |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101560621 Publication Model: eCollection Cited Medium: Print ISSN: 1664-8021 (Print) Linking ISSN: 16648021 NLM ISO Abbreviation: Front Genet Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation. |
مستخلص: | Five years after the identification of Zika virus as a human teratogen, we reviewed the early clinical manifestations, collectively called congenital Zika syndrome (CZS). Children with CZS have a very poor prognosis with extremely low performance in motor, cognitive, and language development domains, and practically all feature severe forms of cerebral palsy. However, these manifestations are the tip of the iceberg, with some children presenting milder forms of deficits. Additionally, neurodevelopment can be in the normal range in the majority of the non-microcephalic children born without brain or eye abnormalities. Vertical transmission and the resulting disruption in development of the brain are much less frequent when maternal infection occurs in the second half of the pregnancy. Experimental studies have alerted to the possibility of other behavioral outcomes both in prenatally infected children and in postnatal and adult infections. Cofactors play a vital role in the development of CZS and involve genetic, environmental, nutritional, and social determinants leading to the asymmetric distribution of cases. Some of these social variables also limit access to multidisciplinary professional treatment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Schuler-Faccini, del Campo, García-Alix, Ventura, Boquett, van der Linden, Pessoa, van der Linden Júnior, Ventura, Leal, Kowalski, Rodrigues Gerzson, Skilhan de Almeida, Santi, Beys-da-Silva, Quincozes-Santos, Guimarães, Garcez, Gomes, Vianna, Anjos da Silva, Fraga, Vieira Sanseverino, Muotri, Lopes da Rosa, Abeche, Marcolongo-Pereira and Souza.) |
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فهرسة مساهمة: | Keywords: cerebral palsy; epilepsy; eye; microcephaly; neurodevelopement; zika (ZIKV) |
تواريخ الأحداث: | Date Created: 20220330 Latest Revision: 20220401 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8957982 |
DOI: | 10.3389/fgene.2022.758715 |
PMID: | 35350244 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-8021 |
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DOI: | 10.3389/fgene.2022.758715 |