دورية أكاديمية
Diurnal Variation of Real-Life Insulin Sensitivity Factor Among Children and Adolescents With Type 1 Diabetes Using Ultra-Long-Acting Basal Insulin Analogs.
| العنوان: | Diurnal Variation of Real-Life Insulin Sensitivity Factor Among Children and Adolescents With Type 1 Diabetes Using Ultra-Long-Acting Basal Insulin Analogs. |
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| المؤلفون: | Hegab AM; Department of Pediatrics, Faculty of Medicine, Sohag University, Sohag, Egypt. |
| المصدر: | Frontiers in pediatrics [Front Pediatr] 2022 Mar 08; Vol. 10, pp. 854972. Date of Electronic Publication: 2022 Mar 08 (Print Publication: 2022). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101615492 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2360 (Print) Linking ISSN: 22962360 NLM ISO Abbreviation: Front Pediatr Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Media SA, [2013]- |
| مستخلص: | Background: Estimation of insulin sensitivity factor (ISF) is essential for correction insulin doses calculation. This study aimed to assess real-life ISF among children and adolescents with type 1 diabetes using ultra-long-acting basal insulin analogs and to detect factors associated with ISF among those patients. Methods: This prospective observational study was conducted at Sohag University Hospital, Egypt, and included 93 participants aged 6-18 years, diagnosed with T1DM for at least 1 year and using insulin glargine 300 Units/mL or insulin degludec 100 Units/mL as basal insulin. The ISF, insulin-to-carbohydrate ratio (ICR) and insulin doses were initially assessed then adjusted as required. The participants were regularly contacted throughout the follow-up period. Glycemic control parameters were assessed after 3 months. Results: The ISF showed diurnal variation with higher correction dose requirements for the morning than for the rest of the day ( p < 0.001). This pattern of diurnal variation was found in participants with different pubertal stages and in participants using either type of ultra-long acting basal insulin analogs. There was no significant difference between the ISF calculated according to the 1800 rule [1800/Total daily insulin dose (TDD)] and the morning ISF ( p = 0.25). The 1800 rule-calculated ISF was significantly lower than the actual ISF for the afternoon ( p < 0.001) and the evening ( p < 0.001). ISF at different times of the day were significantly correlated with age, body mass index, pubertal stage, diabetes duration, TDD, and ICR. Multiple regression analysis revealed that ICR was the most significant factor associated with ISF. Linear regression analysis revealed that the ISF (in mg/dL) for any time of the day could be estimated as 5.14 × ICR for the same time of the day (coefficient = 5.14, 95% confidence interval: 5.10-5.19, R 2 = 0.95, p < 0.001). Conclusion: Diurnal variation of ISF that had to be considered for proper calculation of correction doses. This diurnal variation was found in children and adolescents with different pubertal stages. The 1800 rule was appropriate for the morning correction doses but not in the afternoon or the evening. The TDD and the ICR could be used for ISF estimation. Competing Interests: The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Hegab.) |
| References: | Pediatr Diabetes. 2007 Oct;8 Suppl 6:49-56. (PMID: 17727385) Adipocyte. 2013 Jul 1;2(3):128-34. (PMID: 23991358) Eur J Pediatr. 2011 Jan;170(1):35-43. (PMID: 20676898) Pediatr Diabetes. 2018 Oct;19 Suppl 27:178-192. (PMID: 29869358) Arch Dis Child. 1970 Feb;45(239):13-23. (PMID: 5440182) Pediatr Diabetes. 2018 Oct;19 Suppl 27:105-114. (PMID: 30058221) J Diabetes Sci Technol. 2014 Jan 1;8(1):170-178. (PMID: 24876553) Front Endocrinol (Lausanne). 2019 Jun 04;10:342. (PMID: 31214120) Curr Med Res Opin. 2017 Oct;33(10):1821-1831. (PMID: 28537449) Pediatr Res. 2000 Sep;48(3):384-8. (PMID: 10960508) Pediatr Diabetes. 2006 Aug;7 Suppl 4:25-31. (PMID: 16774615) Pediatr Diabetes. 2018 Oct;19 Suppl 27:136-154. (PMID: 30062718) Pediatr Diabetes. 2018 Oct;19 Suppl 27:205-226. (PMID: 30133095) Curr Diab Rep. 2016 Jul;16(7):64. (PMID: 27179965) JAMA. 2017 Jul 04;318(1):33-44. (PMID: 28672316) Pediatr Diabetes. 2019 Dec;20(8):1087-1093. (PMID: 31433557) J Clin Endocrinol Metab. 1995 Jan;80(1):172-8. (PMID: 7829608) Int J Environ Res Public Health. 2020 Nov 21;17(22):. (PMID: 33233346) Arch Dis Child. 1969 Jun;44(235):291-303. (PMID: 5785179) Diabetes Care. 2021 Jan;44(1):125-132. (PMID: 33444161) J Investig Med. 2021 Jun;69(5):983-988. (PMID: 33771843) J Diabetes Sci Technol. 2007 Jan;1(1):42-6. (PMID: 19888378) Nat Rev Endocrinol. 2020 Mar;16(3):177-189. (PMID: 32020062) Int J Obes Relat Metab Disord. 2002 May;26(5):701-9. (PMID: 12032756) Diabetes Ther. 2020 Jan;11(1):97-105. (PMID: 31707573) J Diabetes Sci Technol. 2012 Jan 01;6(1):191-203. (PMID: 22401339) Clin Cornerstone. 2008;9(1):23-29; discussion 30-1. (PMID: 19046737) Pediatr Diabetes. 2018 Oct;19 Suppl 27:115-135. (PMID: 29999222) Pediatr Diabetes. 2007 Oct;8 Suppl 6:57-62. (PMID: 17727386) J Diabetes Sci Technol. 2017 Mar;11(2):247-252. (PMID: 27470666) J Diabetes Sci Technol. 2021 May 6;:19322968211008442. (PMID: 33955251) Curr Diab Rep. 2016 Sep;16(9):83. (PMID: 27457238) Endocrinol Metab Clin North Am. 2014 Mar;43(1):75-102. (PMID: 24582093) Ann Pediatr Endocrinol Metab. 2017 Sep;22(3):145-152. (PMID: 29025199) Endocr Pract. 2008 Dec;14(9):1095-101. (PMID: 19158048) Diabetes Care. 2019 Apr;42(4):545-552. (PMID: 30705062) Diabetes Obes Metab. 2018 Jan;20(1):121-128. (PMID: 28661585) Endocr Pract. 2005 Jan-Feb;11(1):55-64. (PMID: 16033737) Bull World Health Organ. 2007 Sep;85(9):660-7. (PMID: 18026621) Diabetes Ther. 2021 Nov;12(11):2993-3009. (PMID: 34599749) Pediatr Diabetes. 2016 Aug;17(5):319-26. (PMID: 25998469) Diabetes. 1999 Oct;48(10):2039-44. (PMID: 10512371) Diabetes Technol Ther. 2012 May;14(5):418-22. (PMID: 22239470) J Cardiometab Syndr. 2006 Summer;1(4):242-7. (PMID: 17679804) Endocr Pract. 2013 Sep-Oct;19(5):805-11. (PMID: 23757622) Pediatrics. 2006 Feb;117(2):544-59. (PMID: 16452380) Nutrients. 2018 Jan 22;10(1):. (PMID: 29361766) Diabet Med. 2016 Oct;33(10):1360-5. (PMID: 26773826) World J Diabetes. 2015 Feb 15;6(1):8-16. (PMID: 25685274) Metabolism. 2002 Aug;51(8):1011-6. (PMID: 12145774) Pediatr Diabetes. 2009 Aug;10(5):336-42. (PMID: 19175894) Gend Med. 2009;6 Suppl 1:60-75. (PMID: 19318219) Diabetes Care. 2017 Apr;40(4):554-560. (PMID: 28115474) Pediatr Diabetes. 2018 Oct;19 Suppl 27:193-204. (PMID: 30079506) |
| فهرسة مساهمة: | Keywords: children and adolescents; insulin analogs; insulin sensitivity factor; multiple daily injection; type 1 diabetes |
| تواريخ الأحداث: | Date Created: 20220330 Latest Revision: 20220401 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8957904 |
| DOI: | 10.3389/fped.2022.854972 |
| PMID: | 35350271 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2296-2360 |
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| DOI: | 10.3389/fped.2022.854972 |