دورية أكاديمية
Persistence and shedding of senecavirus A in naturally infected boars.
| العنوان: | Persistence and shedding of senecavirus A in naturally infected boars. |
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| المؤلفون: | Sturos MJ; Veterinary Diagnostic Laboratory., Murray D; College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA; New Fashion Pork, Jackson, MN, USA., Johnson L; College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA; New Fashion Pork, Jackson, MN, USA., Preis G; Department of Veterinary Population Medicine., Corzo CA; Department of Veterinary Population Medicine., Rossow S; Veterinary Diagnostic Laboratory., Vannucci FA; Veterinary Diagnostic Laboratory. |
| المصدر: | Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc [J Vet Diagn Invest] 2022 May; Vol. 34 (3), pp. 474-481. Date of Electronic Publication: 2022 Mar 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: United States NLM ID: 9011490 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-4936 (Electronic) Linking ISSN: 10406387 NLM ISO Abbreviation: J Vet Diagn Invest Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2011-: Thousand Oaks, CA : Sage Original Publication: 1989-2004 : Columbia, MO : American Association of Veterinary Laboratory Diagnosticians |
| مواضيع طبية MeSH: | Picornaviridae*/genetics , Swine Diseases*/epidemiology, Animals ; Female ; Male ; RNA ; Swine ; Viremia/veterinary |
| مستخلص: | Senecavirus A (SVA) infection in pigs causes vesicular disease and results in a short viremia and transient shedding of the virus, mainly in oral fluids and feces. Here we describe the consistent prolonged shedding of SVA in the semen of 2 boars, and persistence of SVA within the tonsils and testes of 3 adult boars. Two SVA-infected boars that were identified on a Minnesota sow farm in 2017 shed SVA RNA in semen for >3 mo after an outbreak of vesicular disease had occurred on the farm. SVA was isolated from 1 semen sample collected 9 d after clinical disease began on the farm. The third SVA-infected boar was identified on an Indiana sow farm in 2020. All boars had SVA RNA detected in the testes and tonsils by RT-rtPCR, with lower Ct values obtained for the testes than from the tonsils. All boars had multifocal lymphocytic orchitis with segmental degeneration and atrophy of the germinal epithelium within the seminiferous tubules. One boar also had areas of seminiferous tubule collapse and interstitial fibrosis within the testes. In all boars, in situ hybridization demonstrated the presence of SVA mRNA within cells located basally in the seminiferous tubules of the testes, and within the basal surface epithelial cells, crypt epithelial cells, and subepithelial and parafollicular lymphocytes and histiocytes of the tonsil. |
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| فهرسة مساهمة: | Keywords: boars; orchitis; persistence; semen; senecavirus A; shedding; swine; testis |
| المشرفين على المادة: | 63231-63-0 (RNA) |
| SCR Organism: | Senecavirus A |
| تواريخ الأحداث: | Date Created: 20220331 Date Completed: 20220503 Latest Revision: 20230401 |
| رمز التحديث: | 20230403 |
| مُعرف محوري في PubMed: | PMC9254050 |
| DOI: | 10.1177/10406387221084054 |
| PMID: | 35354385 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1943-4936 |
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| DOI: | 10.1177/10406387221084054 |