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Frontolimbic Network Topology Associated With Risk and Presence of Depression in Adolescents: A Study Using a Composite Risk Score in Brazil.

التفاصيل البيبلوغرافية
العنوان: Frontolimbic Network Topology Associated With Risk and Presence of Depression in Adolescents: A Study Using a Composite Risk Score in Brazil.
المؤلفون: Yoon L; Department of Human Ecology, University of California, Davis, Davis, California., Rohrsetzer F; Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Battel L; Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; Department of Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York., Anés M; Division of Medical Physics and Radioprotection, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil., Manfro PH; Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Rohde LA; Institute of Developmental Psychiatry for Children and Adolescents, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil; ADHD Outpatient and Developmental Psychiatry Programs, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil., Viduani A; Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Zajkowska Z; Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, London, United Kingdom., Mondelli V; Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, London, United Kingdom; National Institute for Health Research Maudsley Biomedical Research Centre, South London and Maudsley National Health Service Foundation Trust, King's College London, London, United Kingdom., Kieling C; Department of Psychiatry, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Swartz JR; Department of Human Ecology, University of California, Davis, Davis, California. Electronic address: jrswartz@ucdavis.edu.
المصدر: Biological psychiatry. Cognitive neuroscience and neuroimaging [Biol Psychiatry Cogn Neurosci Neuroimaging] 2023 Apr; Vol. 8 (4), pp. 426-435. Date of Electronic Publication: 2022 Mar 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 101671285 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9030 (Electronic) Linking ISSN: 24519022 NLM ISO Abbreviation: Biol Psychiatry Cogn Neurosci Neuroimaging Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier, Inc., [2016]-
مواضيع طبية MeSH: Depression* , Brain Mapping*, Humans ; Adolescent ; Brazil/epidemiology ; Magnetic Resonance Imaging/methods ; Risk Factors
مستخلص: Background: There have been significant challenges in understanding functional brain connectivity associated with adolescent depression, including the need for a more comprehensive approach to defining risk, the lack of representation of participants from low- and middle-income countries, and the need for network-based approaches to model connectivity. The current study aimed to address these challenges by examining resting-state functional connectivity of frontolimbic circuitry associated with the risk and presence of depression in adolescents in Brazil.
Methods: Adolescents in Brazil ages 14 to 16 years were classified into low-risk, high-risk, and depressed groups using a clinical assessment and composite risk score that integrates 11 sociodemographic risk variables. After excluding participants with excessive head movement, resting-state functional magnetic resonance imaging data of 126 adolescents were analyzed. We compared group differences in frontolimbic network connectivity using region of interest-to-region of interest, graph theory, and seed-based connectivity analyses. Associations between self-reported depressive symptoms and brain connectivity were also explored.
Results: Adolescents with depression showed greater dorsal anterior cingulate cortex (ACC) connectivity with the orbitofrontal cortex compared with the 2 risk groups and greater dorsal ACC global efficiency than the low-risk group. Adolescents with depression also showed reduced local efficiency and a lower clustering coefficient of the subgenual ACC compared with the 2 risk groups. The high-risk group also showed a lower subgenual ACC clustering coefficient relative to the low-risk group.
Conclusions: These findings highlight altered connectivity and topology of the ACC within frontolimbic circuitry as potential neural correlates and risk factors of developing depression in adolescents in Brazil. This study broadens our understanding of the neural connectivity associated with adolescent depression in a global context.
(Copyright © 2022 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.)
معلومات مُعتمدة: MC_PC_MR/R019460/1 United Kingdom MRC_ Medical Research Council; MRF_MRF-160-0005-ELP-MONDE United Kingdom MRF MRF
فهرسة مساهمة: Keywords: Adolescent depression; Anterior cingulate cortex; Frontolimbic circuit; Graph theory; Orbitofrontal cortex; Resting-state functional connectivity
تواريخ الأحداث: Date Created: 20220331 Date Completed: 20230411 Latest Revision: 20240306
رمز التحديث: 20240306
DOI: 10.1016/j.bpsc.2022.03.008
PMID: 35358744
قاعدة البيانات: MEDLINE
الوصف
تدمد:2451-9030
DOI:10.1016/j.bpsc.2022.03.008