دورية أكاديمية
أعرض في EDS

Bone Density and Structure in Overweight Men With and Without Diabetes.

التفاصيل البيبلوغرافية
العنوان: Bone Density and Structure in Overweight Men With and Without Diabetes.
المؤلفون: Starup-Linde J; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.; Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark., Ornstrup MJ; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark., Kjær TN; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark., Lykkeboe S; Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark., Handberg A; Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, The Faculty of Medicine, Aalborg University, Aalborg, Denmark., Gregersen S; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark., Harsløf T; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark., Pedersen SB; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark., Vestergaard P; Steno Diabetes Center North Jutland, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, The Faculty of Medicine, Aalborg University, Aalborg, Denmark.; Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark., Langdahl BL; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.
المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2022 Mar 10; Vol. 13, pp. 837084. Date of Electronic Publication: 2022 Mar 10 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Bone Density* , Diabetes Mellitus, Type 2*/complications, Cross-Sectional Studies ; Humans ; Male ; Overweight/complications ; Spine
مستخلص: Objective: Metabolic syndrome (MetS), type 1 diabetes (T1D), and type 2 diabetes, are associated with an increased risk of fractures; however, the impact of obesity on bone deficits in diabetes is unknown. We aimed to compare markers of bone structure, bone density, and bone turnover in non-diabetic overweight men with MetS and overweight men with T1D or T2D.
Methods and Research Design: In this cross-sectional study we included participants from two previously described study cohorts consisting of participants with diabetes and participants with MetS. Participants underwent dual-energy X-ray absorptiometry measuring areal bone mineral density (aBMD) at the hip and lumbar spine, High Resolution peripheral Quantitative (HRpQCT) scan of the tibia and radius and measurement of circulating bone turnover markers. We compared groups with unpaired t test and performed multiple linear regression with adjustment for age, body mass index, and smoking.
Results: We included 33 participants with T1D, 25 participants with T2D, and 34 participants with MetS. Bone turnover markers levels were comparable between T1D and MetS. aBMD at the hip was lower in T1D compared to MetS, also after adjustment. P1NP and Osteocalcin levels were lower among individuals with T2D compared to MetS, whereas aBMD were similar between the groups after multiple adjustments. We observed no difference in volumetric BMD at the tibia or radius between MetS and T1D and T2D, respectively. Participants with T2D had a higher trabecular number and lower trabecular separation compared to individuals with MetS at the tibia, which remained signficant after multiple adjustments.
Conclusion: In conclusion, we observed no clinically important differences in bone density or structure between men with T2D, T1D, or MetS. However, men with T2D displayed lower bone turnover compared to MetS highlighting that T2D per se and not obesity, is associated with low bone turnover.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Starup-Linde, Ornstrup, Kjær, Lykkeboe, Handberg, Gregersen, Harsløf, Pedersen, Vestergaard and Langdahl.)
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فهرسة مساهمة: Keywords: HRpQCT; bone mineral density; bone turnover (markers); diabetes; metabolic syndrome
تواريخ الأحداث: Date Created: 20220401 Date Completed: 20220404 Latest Revision: 20220519
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8960162
DOI: 10.3389/fendo.2022.837084
PMID: 35360074
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-2392
DOI:10.3389/fendo.2022.837084