دورية أكاديمية
Interaction of esomeprazole with insulin detemir and human albumin: A potential cause of hypoglycemia.
| العنوان: | Interaction of esomeprazole with insulin detemir and human albumin: A potential cause of hypoglycemia. |
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| المؤلفون: | Hamdan II; Department of Pharmaceutical Sciences, School of Pharmacy, The University of Jordan, Amman, Jordan. Electronic address: I.Hamdan@ju.edu.jo., Farah DGH; Department of Pharmacy, Faculty of Pharmacy, Zarqa University, Zarqa, Jordan., Khalil EA; Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy, The University of Jordan, Amman, Jordan., Mansour RSH; Faculty of Pharmacy, Philadelphia University, Amman, Jordan., Abdel-Halim H; Faculty of Pharmacy and Medical Sciences, University of Petra,Amman, Jordan. |
| المصدر: | Biophysical chemistry [Biophys Chem] 2022 Jun; Vol. 285, pp. 106809. Date of Electronic Publication: 2022 Mar 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 0403171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4200 (Electronic) Linking ISSN: 03014622 NLM ISO Abbreviation: Biophys Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Science B.V Original Publication: Amsterdam, North-Holland Pub. Co. |
| مواضيع طبية MeSH: | Esomeprazole*/adverse effects , Hypoglycemia*/chemically induced , Insulin Detemir*/adverse effects, Drug Interactions ; Fatty Acids ; Humans ; Hypoglycemic Agents/adverse effects ; Insulin ; Molecular Docking Simulation ; Serum Albumin, Human |
| مستخلص: | Insulin detemir (IDt) is long-acting insulin whose protraction mechanism is based on a covalently attached fatty acid to an insulin molecule. Utilizing the high affinity of fatty acids towards human serum albumin (HA), the modified detemir molecule binds with good affinity to HA, which functions as a reservoir that leads to a slow and prolonged release of insulin. However, questions were raised over potential interactions between other drugs and IDt through competitive binding on the binding site(s) of HA. In a previous study, concomitant use of esomeprazole (Esom) and erythromycin resulted in severe hypoglycemia, and thus: the drugs including Esom were suggested as enhancers of IDt action through displacing it from its binding site on HA. To further study this possibility, studies utilizing different techniques including, semipermeable membrane dialysis, capillary electrophoresis, UV,NMR spectroscopy, and molecular docking were carried out. Results from various techniques supported the simultaneous binding of Esom along with IDt to HA (i.e., binding in two different sites without signs of competition between the two). Moreover, capillary electrophoresis suggested an increase in the binding affinity of Esom to HA in the presence of IDt (1.9 × 10 3 Vs 2.7 × 10 4 M -1 ). Perhaps most interesting was the observation that Esom could bind directly to IDt which was evidenced by all the employed techniques. Direct binding of Esom to IDt, might explain the enhancement in insulin action associated with the concomitant use of Esom. Therefore, Esom might represent a leading insulin-sensitizing compound that might lead to more effective insulin enhancing and less unwanted effects. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Albumin; Detemir; Esomeprazole; Insulin; Levemir; Molecular docking |
| المشرفين على المادة: | 0 (Fatty Acids) 0 (Hypoglycemic Agents) 0 (Insulin) 4FT78T86XV (Insulin Detemir) N3PA6559FT (Esomeprazole) ZIF514RVZR (Serum Albumin, Human) |
| تواريخ الأحداث: | Date Created: 20220403 Date Completed: 20220412 Latest Revision: 20220531 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.bpc.2022.106809 |
| PMID: | 35367785 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4200 |
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| DOI: | 10.1016/j.bpc.2022.106809 |