دورية أكاديمية
أعرض في EDS

Clinical Characteristics and Long-Term Outcomes of Patients With Differing Haemoglobin Levels Undergoing Semi-Urgent and Elective Percutaneous Coronary Intervention in an Asian Population.

التفاصيل البيبلوغرافية
العنوان: Clinical Characteristics and Long-Term Outcomes of Patients With Differing Haemoglobin Levels Undergoing Semi-Urgent and Elective Percutaneous Coronary Intervention in an Asian Population.
المؤلفون: Soh RY; Department of Cardiology, National University Heart Centre, Singapore, Singapore., Sia CH; Department of Cardiology, National University Heart Centre, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore., Djohan AH; Department of Cardiology, National University Heart Centre, Singapore, Singapore., Lau RH; Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore., Ho PY; Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore., Neo JW; Department of Cardiology, National University Heart Centre, Singapore, Singapore., Ho JS; School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom., Sim HW; Department of Cardiology, National University Heart Centre, Singapore, Singapore., Yeo TC; Department of Cardiology, National University Heart Centre, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore., Tan HC; Department of Cardiology, National University Heart Centre, Singapore, Singapore., Chan MY; Department of Cardiology, National University Heart Centre, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore., Loh JP; Department of Cardiology, National University Heart Centre, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore.
المصدر: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2022 Mar 18; Vol. 9, pp. 687555. Date of Electronic Publication: 2022 Mar 18 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101653388 Publication Model: eCollection Cited Medium: Print ISSN: 2297-055X (Print) Linking ISSN: 2297055X NLM ISO Abbreviation: Front Cardiovasc Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2014]-
مستخلص: Introduction: This study aimed to investigate the impact of anaemia on long-term clinical outcomes in patients who underwent semi-urgent and elective percutaneous coronary intervention (PCI) in an Asian population. Although the effects of anaemia on outcomes in Asian patients are well studied for acute coronary syndrome, its impact on Asian patients undergoing semi-urgent and elective PCI is unclear.
Methods: This was a retrospective cohort study of patients who underwent semi-urgent and elective PCI from January 1, 2014, to December 31, 2015, at a tertiary academic centre. A total of 1,685 patients were included. They were stratified into three groups: normal (≥12 g/dL), intermediate (10-11.9 g/dL), and low (<10 g/dL) haemoglobin levels. Demographics, risk factors, and end-points including the 5-point major adverse cardiac and cerebrovascular events (MACCE) (all-cause death, subsequent stroke, myocardial infarction, congestive cardiac failure, and target lesion revascularisation), cardiovascular death, and bleeding events were analysed.
Results: Patients in intermediate and low haemoglobin level groups were older with more comorbidities. Compared to the normal haemoglobin level group, low haemoglobin level group patients were associated with an increased risk of composite endpoints of all-cause death, subsequent stroke, myocardial infarction, congestive cardiac failure, and target lesion revascularisation [adjusted hazard ratio (aHR) 1.89, 95% confidence interval (CI):1.22, 2.92; p = 0.004]. This was driven by the increased risk of target lesions revascularisation observed in the low haemoglobin level group compared to the normal haemoglobin level group (aHR 17.74, 95% CI: 1.74, 180.80; p = 0.015). The patients in the low haemoglobin level group were also associated with a higher risk of bleeding events compared to the normal haemoglobin level group (aHR 7.18, 95% CI: 1.13, 45.40; p = 0.036).
Conclusion: In our Asian cohort, patients with anaemia undergoing PCI were associated with a higher comorbid burden. Despite adjustments for comorbidities, these patients had higher mortality and worse cardiovascular outcomes following contemporary PCI.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Soh, Sia, Djohan, Lau, Ho, Neo, Ho, Sim, Yeo, Tan, Chan and Loh.)
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فهرسة مساهمة: Keywords: Asian; anaemia; bleeding event; cardiovascular outcomes; percutaneous coronary intervention
تواريخ الأحداث: Date Created: 20220404 Latest Revision: 20220405
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8971291
DOI: 10.3389/fcvm.2022.687555
PMID: 35369342
قاعدة البيانات: MEDLINE
الوصف
تدمد:2297-055X
DOI:10.3389/fcvm.2022.687555