دورية أكاديمية
New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum.
| العنوان: | New anti-pulmonary fibrosis prenylflavonoid glycosides from Epimedium koreanum. |
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| المؤلفون: | Zhao YD; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China., Zhang X; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China., Yang WY; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China., Zhang RQ; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China., Mu LT; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China., Han L; NERC for the Pharmaceutics of Traditional Chinese Medicines, Benxi 117004, China., Lv CN; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Liaoning Provincial Key Laboratory of TCM Resources Conservation and Development, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: lcnmi@outlook.com., Lu JC; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; Liaoning Provincial Key Laboratory of TCM Resources Conservation and Development, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: jincailu@syphu.edu.cn. |
| المصدر: | Chinese journal of natural medicines [Chin J Nat Med] 2022 Mar; Vol. 20 (3), pp. 221-228. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Science Press Country of Publication: China NLM ID: 101504416 Publication Model: Print Cited Medium: Internet ISSN: 1875-5364 (Electronic) Linking ISSN: 18755364 NLM ISO Abbreviation: Chin J Nat Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2009-> : Beijing : Science Press ; Elsevier Original Publication: Nanjing : Ke xue chu ban she |
| مواضيع طبية MeSH: | Epimedium*/chemistry, Chromatography, High Pressure Liquid ; Glycosides/chemistry ; Glycosides/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plant Leaves/chemistry |
| مستخلص: | Four new prenylflavonoid glycosides, namely koreanoside H-K (1-4), together with eleven known ones (5-15) were isolated from the leaves of Epimedium koreanum Nakai. Their structures were elucidated by 1D NMR, 2D NMR, HR-ESI-MS, IR and UV. The identification of the sugar moieties was carried out by means of acid hydrolysis and HPLC analysis of their derivatives. It is worth noting that compound 3 and compound 4 were elucidated to contain fucose and quinovose moieties, which were two extremely rare sugar units from the genus Epimedium. The anti-pulmonary fibrosis activity of the new compounds was evaluated using A549 cell line. Compounds 1, 2 and 4 showed significant anti-pulmonary fibrosis activities. (Copyright © 2022 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anti-pulmonary fibrosis; Epimedium koreanum; Prenylflavonoid glycoside |
| المشرفين على المادة: | 0 (Glycosides) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20220404 Date Completed: 20220405 Latest Revision: 20220405 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/S1875-5364(21)60116-4 |
| PMID: | 35369967 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1875-5364 |
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| DOI: | 10.1016/S1875-5364(21)60116-4 |