دورية أكاديمية
أعرض في EDS

Serum and Urinary Neutrophil Gelatinase-Associated Lipocalin Are Not Associated With Serum Redox Parameters in Amateur Athletes After an Ultramarathon.

التفاصيل البيبلوغرافية
العنوان: Serum and Urinary Neutrophil Gelatinase-Associated Lipocalin Are Not Associated With Serum Redox Parameters in Amateur Athletes After an Ultramarathon.
المؤلفون: Loureiro ACC; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Brazil., Nocrato GF; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Brazil., Correia ALL; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Brazil., de Matos RS; Department of Clinical Medicine at the Federal University of Ceará, Ceará Federal University, Fortaleza, Brazil., Filho JCCN; Department of Clinical Medicine at the Federal University of Ceará, Ceará Federal University, Fortaleza, Brazil., Daher EF; Department of Clinical Medicine at the Federal University of Ceará, Ceará Federal University, Fortaleza, Brazil., Pinto FHM; Treatment and Integration Center of the Being, Fortaleza, Brazil., de Oliveira AC; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Brazil., Ceccatto VM; Superior Institute of Biomedical Sciences, Ceará State University, Fortaleza, Brazil., Fortunato RS; Carlos Chagas Filho Biophysics Institute, Rio de Janeiro Federal University, Rio de Janeiro, Brazil., de Carvalho DP; Carlos Chagas Filho Biophysics Institute, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.
المصدر: Frontiers in physiology [Front Physiol] 2022 Mar 17; Vol. 13, pp. 811514. Date of Electronic Publication: 2022 Mar 17 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Objective: To evaluate the relationship between oxidative stress and NGAL levels in blood and urine of amateur athletes after participating in a 100 km ultramarathon.
Methodology: The sample was composed of seven athletes, submitted to anthropometric assessment, cardiopulmonary exercise test, collection of urine and blood, measurement of body weight. The rate of perceived exertion (RPE), competition duration, heart rate (HR), energy expenditure and oxygen consumption (V'O 2 ") were also measured during the event. The energy consumption during the race was verified at its end. The analyses were based on the means (M) and respective standard deviations (SD), with statistical significance set at 5% ( p < 0.05). Paired t -test was used for comparison between the periods before and after the competition, and Pearson's correlation coefficient was used to measure the linear correlation between quantitative variables.
Results: Body mass index (BMI) of the sample was 25.75 kg/m 2 ± 3.20, body fat percentage 18.54% ± 4.35% and V'O 2 " max 48.87% ± 4.78. Glucose, cortisol, and neutrophil gelatinase-associated lipocalin (NGAL) ( p < 0.01) as well as glutathione peroxidase (GPx) active were higher after the race when compared to basal values. Moreover, lactate, creatinine, microalbuminuria, and glomerular filtration rate (GFR) ( p < 0.001) were also higher after the race. After the competition, there was a significant correlation only between serum NGAL and creatinine, which was classified as strong and positive (r: 0.77; p < 0.05). There was a significant reduction ( p < 0.05) of body weight after the event (72.40 kg ± 9.78) compared to before it (73.98 kg ± 10.25). In addition, we found an increase of RPE ( p < 0.001) after the race. The competition lasted 820.60 min (±117.00), with a 127.85 bpm (±12.02) HR, a 2209.72 kcal ± 951.97 energy consumption, 7837.16 kcal ± 195.71 energy expenditure, and 28.78 ml/kg/min -1 (±4.66) relative V'O 2 " max .
Conclusion: The lack of correlation between oxidative stress biomarkers and serum and urine NGAL suggests that NGAL is more sensitive to inflammatory processes than to ROS levels.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 Loureiro, Nocrato, Correia, de Matos, Filho, Daher, Pinto, de Oliveira, Ceccatto, Fortunato and de Carvalho.)
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فهرسة مساهمة: Keywords: NGAL; amateur athletes; oxidative stress; physiological markers; ultramarathon
تواريخ الأحداث: Date Created: 20220404 Latest Revision: 20231103
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8970054
DOI: 10.3389/fphys.2022.811514
PMID: 35370771
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-042X
DOI:10.3389/fphys.2022.811514