دورية أكاديمية
Plasma Interleukin-33 Cannot Predict Hip Osteonecrosis in Patients With Sickle Cell Disease: A Case-Control Study.
العنوان: | Plasma Interleukin-33 Cannot Predict Hip Osteonecrosis in Patients With Sickle Cell Disease: A Case-Control Study. |
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المؤلفون: | Agrawal AC; Orthopaedics, All India Institute of Medical Sciences, Raipur, Raipur, IND., Mohapatra E; Biochemistry, All India Institute of Medical Sciences, Raipur, Raipur, IND., Nanda R; Biochemistry, All India Institute of Medical Sciences, Raipur, Raipur, IND., Bodhey NK; Radiodiagnosis, All India Institute of Medical Sciences, Raipur, Raipur, IND., Sakale H; Orthopaedics, All India Institute of Medical Sciences, Raipur, Raipur, IND., Garg AK; Orthopaedics, All India Institute of Medical Sciences, Raipur, Raipur, IND. |
المصدر: | Cureus [Cureus] 2022 Mar 28; Vol. 14 (3), pp. e23556. Date of Electronic Publication: 2022 Mar 28 (Print Publication: 2022). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: eCollection Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Palo Alto, CA : Cureus, Inc. |
مستخلص: | Background Plasma interleukin-33 (IL-33), a cytokine associated with inflammatory and autoimmune disease, has been described to be significantly raised in osteonecrosis of the femoral head (ONFH) and hence was recommended for use as a marker for ONFH. The concentration of plasma interleukin-33 level has not been estimated in any studies conducted in patients with sickle cell disease (SCD); hence, we investigated the levels of plasma interleukin-33 in patients with sickle cell disease with or without ONFH to assess whether it can be used as a marker for the early detection of ONFH in this disease also. Methods Forty-four consecutive patients with sickle cell disease with osteonecrosis of the femoral head and matched controls without ONFH were evaluated for plasma interleukin-33 levels by enzyme-linked immunosorbent assay (ELISA). All patients were confirmed for sickle cell disease using high-performance liquid chromatography (HPLC). ONFH was diagnosed in patients with sickle cell disease using clinical-radiological findings. Univariate and multivariate analyses were performed using the IL-33 level as the dependent variable. Results Plasma IL-33 levels were comparable in 44 patients with sickle cell disease with osteonecrosis of the femoral head as compared with 24 patients with sickle cell disease without ONFH (2.05 ± 4.57 pg/mL versus 1.50 ± 2.89 pg/mL, p-value = 0.590). There was no significant difference in IL-33 levels in different stages of avascular necrosis (AVN). Conclusions Plasma interleukin-33 levels cannot act as a marker of ONFH as were being considered in idiopathic ONFH or ONFH caused by other causes such as trauma and chronic steroid or alcohol usage. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Agrawal et al.) |
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فهرسة مساهمة: | Keywords: avn; hip; osteonecrosis of the femoral head; plasma interleukin-33 level; sickle cell disease |
تواريخ الأحداث: | Date Created: 20220404 Latest Revision: 20220405 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8971072 |
DOI: | 10.7759/cureus.23556 |
PMID: | 35371856 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2168-8184 |
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DOI: | 10.7759/cureus.23556 |