دورية أكاديمية
Effects of elevation of ANP and its deficiency on cardiorenal function.
| العنوان: | Effects of elevation of ANP and its deficiency on cardiorenal function. |
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| المؤلفون: | Ilatovskaya DV; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.; Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina, USA., Levchenko V; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.; Department of Molecular Pharmacology and Physiology and., Winsor K; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Blass GR; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Spires DR; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.; Department of Physiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA., Sarsenova E; Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina, USA., Polina I; Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina, USA., Zietara A; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.; Department of Molecular Pharmacology and Physiology and., Paterson M; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Kriegel AJ; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA., Staruschenko A; Department of Molecular Pharmacology and Physiology and.; Hypertension and Kidney Research Center, University of South Florida, College of Medicine, Tampa, Florida, USA.; James A. Haley Veterans' Hospital, Tampa, Florida, USA. |
| المصدر: | JCI insight [JCI Insight] 2022 May 09; Vol. 7 (9). Date of Electronic Publication: 2022 May 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]- |
| مواضيع طبية MeSH: | Atrial Natriuretic Factor*/genetics , Hypertension*, Animals ; Blood Pressure/physiology ; Genome-Wide Association Study ; Rats ; Rats, Inbred Dahl ; Sodium ; Sodium Chloride, Dietary/adverse effects |
| مستخلص: | Atrial natriuretic peptide (ANP), encoded by Nppa, is a vasodilatory hormone that promotes salt excretion. Genome-wide association studies identified Nppa as a causative factor of blood pressure development, and in humans, ANP levels were suggested as an indicator of salt sensitivity. This study aimed to provide insights into the effects of ANP on cardiorenal function in salt-sensitive hypertension. To address this question, hypertension was induced in SSNPPA-/- (KO of Nppa in the Dahl salt-sensitive [SS] rat background) or SSWT (WT Dahl SS) rats by a high-salt (HS) diet challenge (4% NaCl for 21 days). Chronic infusion of ANP in SSWT rats attenuated the increase in blood pressure and cardiorenal damage. Overall, the SSNPPA-/- strain demonstrated higher blood pressure and intensified cardiac fibrosis (with no changes in ejection fraction) compared with SSWT rats. Furthermore, SSNPPA-/- rats exhibited kidney hypertrophy and higher glomerular injury scores, reduced diuresis, and lower sodium and chloride excretion than SSWT when fed a HS diet. Additionally, the activity of epithelial Na+ channel (ENaC) was found to be increased in the collecting ducts of the SSNPPA-/- rats. Taken together, these data show promise for the therapeutic benefits of ANP and ANP-increasing drugs for treating salt-sensitive hypertension. |
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| معلومات مُعتمدة: | I01 BX004024 United States BX BLRD VA; P01 HL116264 United States HL NHLBI NIH HHS; R01 HL148114 United States HL NHLBI NIH HHS; R35 HL135749 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: Hypertension; Nephrology; Sodium channels |
| المشرفين على المادة: | 0 (Sodium Chloride, Dietary) 85637-73-6 (Atrial Natriuretic Factor) 9NEZ333N27 (Sodium) |
| تواريخ الأحداث: | Date Created: 20220405 Date Completed: 20220510 Latest Revision: 20220710 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9090260 |
| DOI: | 10.1172/jci.insight.148682 |
| PMID: | 35380994 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2379-3708 |
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| DOI: | 10.1172/jci.insight.148682 |