دورية أكاديمية
Acoustic Modulation Enables Proton Detection With Nanodroplets at Body Temperature.
| العنوان: | Acoustic Modulation Enables Proton Detection With Nanodroplets at Body Temperature. |
|---|---|
| المؤلفون: | Heymans SV, Collado-Lara G, Rovituso M, Vos HJ, D'hooge J, de Jong N, Van Abeele KD |
| المصدر: | IEEE transactions on ultrasonics, ferroelectrics, and frequency control [IEEE Trans Ultrason Ferroelectr Freq Control] 2022 Jun; Vol. 69 (6), pp. 2028-2038. Date of Electronic Publication: 2022 May 26. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Institute of Electrical and Electronics Engineers Country of Publication: United States NLM ID: 9882735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-8955 (Electronic) Linking ISSN: 08853010 NLM ISO Abbreviation: IEEE Trans Ultrason Ferroelectr Freq Control Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Institute of Electrical and Electronics Engineers, c1985- |
| مواضيع طبية MeSH: | Fluorocarbons* , Protons*, Acoustics ; Body Temperature ; Ultrasonography ; Volatilization |
| مستخلص: | Superheated nanodroplet (ND) vaporization by proton radiation was recently demonstrated, opening the door to ultrasound-based in vivo proton range verification. However, at body temperature and physiological pressures, perfluorobutane nanodroplets (PFB-NDs), which offer a good compromise between stability and radiation sensitivity, are not directly sensitive to primary protons. Instead, they are vaporized by infrequent secondary particles, which limits the precision for range verification. The radiation-induced vaporization threshold (i.e., sensitization threshold) can be reduced by lowering the pressure in the droplet such that ND vaporization by primary protons can occur. Here, we propose to use an acoustic field to modulate the pressure, intermittently lowering the proton sensitization threshold of PFB-NDs during the rarefactional phase of the ultrasound wave. Simultaneous proton irradiation and sonication with a 1.1 MHz focused transducer, using increasing peak negative pressures (PNPs), were applied on a dilution of PFB-NDs flowing in a tube, while vaporization was acoustically monitored with a linear array. Sensitization to primary protons was achieved at temperatures between [Formula: see text] and 40 °C using acoustic PNPs of relatively low amplitude (from 800 to 200 kPa, respectively), while sonication alone did not lead to ND vaporization at those PNPs. Sensitization was also measured at the clinically relevant body temperature (i.e., 37 °C) using a PNP of 400 kPa. These findings confirm that acoustic modulation lowers the sensitization threshold of superheated NDs, enabling a direct proton response at body temperature. |
| المشرفين على المادة: | 0 (Fluorocarbons) 0 (Protons) |
| تواريخ الأحداث: | Date Created: 20220406 Date Completed: 20220530 Latest Revision: 20220623 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1109/TUFFC.2022.3164805 |
| PMID: | 35385380 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1525-8955 |
|---|---|
| DOI: | 10.1109/TUFFC.2022.3164805 |