دورية أكاديمية
أعرض في EDS

Aetiological diagnosis of hyponatraemia in non-critical patients on total parenteral nutrition: A prospective multicentre study.

التفاصيل البيبلوغرافية
العنوان: Aetiological diagnosis of hyponatraemia in non-critical patients on total parenteral nutrition: A prospective multicentre study.
المؤلفون: Ortolá Buigues A; Endocrinology and Nutrition Department, Hospital Clínico Universitario de Valladolid and Centro de Investigación de Endocrinología y Nutrición (IEN), Universidad de Valladolid, Valladolid, Spain. Electronic address: anaortola@hotmail.com., Gómez-Hoyos E; Endocrinology and Nutrition Department, Hospital Clínico Universitario de Valladolid and Centro de Investigación de Endocrinología y Nutrición (IEN), Universidad de Valladolid, Valladolid, Spain., Ballesteros Pomar MD; Endocrinology and Nutrition Department, Complejo Asistencial Universitario de León, León, Spain., Vidal Casariego A; Endocrinology and Nutrition Department, Complejo Asistencial Universitario de León, León, Spain., García Delgado Y; Endocrinology and Nutrition Department, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain., Ocón Bretón MJ; Endocrinology and Nutrition Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain., Abad González ÁL; Endocrinology and Nutrition Department, Hospital General Universitario de Alicante, Alicante, Spain., Luengo Pérez LM; Endocrinology and Nutrition Department, Hospital Universitario Infanta Cristina, Badajoz, Spain., Matía Martín P; Endocrinology and Nutrition Department, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria San Carlos (IDISSC), Madrid, Spain., Tapia Guerrero MJ; Endocrinology and Nutrition Department, Hospital Regional Universitario de Málaga, Málaga, Spain., Del Olmo García MD; Endocrinology and Nutrition Department, Hospital Universitario Severo Ochoa, Leganés, Spain., Herrero Ruiz A; Endocrinology and Nutrition Department, Hospital Clínico Universitario de Salamanca, Salamanca, Spain., Álvarez Hernández J; Endocrinology and Nutrition Department, Hospital Universitario Príncipe de Asturias, Getafe, Spain., Tejera Pérez C; Endocrinology and Nutrition Department, Complejo Hospitalario Universitario de Ferrol, Ferrol, Spain., Herranz Antolín S; Endocrinology and Nutrition Department, Hospital Universitario de Guadalajara, Guadalajara, Spain., Tenorio Jiménez C; Endocrinology and Nutrition Department, Complejo Hospitalario de Jaén, Jaén, Spain., García Zafra MV; Endocrinology and Nutrition Department, Hospital General Universitario Santa Lucía, Cartagena, Spain., Botella Romero F; Endocrinology and Nutrition Department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain., Argente Pla M; Endocrinology and Nutrition Department, Hospital Universitario y Politécnico de La Fe, Valencia, Spain., Martínez Olmos MÁ; Endocrinology and Nutrition Department, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain., Bretón Lemes I; Endocrinology and Nutrition Department, Hospital Universitario Gregorio Marañón, Madrid, Spain., Runkle De la Vega I; Endocrinology and Nutrition Department, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria San Carlos (IDISSC), Madrid, Spain., De Luis Román D; Endocrinology and Nutrition Department, Hospital Clínico Universitario de Valladolid and Centro de Investigación de Endocrinología y Nutrición (IEN), Universidad de Valladolid, Valladolid, Spain.
المصدر: Endocrinologia, diabetes y nutricion [Endocrinol Diabetes Nutr (Engl Ed)] 2022 Mar; Vol. 69 (3), pp. 160-167.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Country of Publication: Spain NLM ID: 101717565 Publication Model: Print Cited Medium: Internet ISSN: 2530-0180 (Electronic) Linking ISSN: 25300180 NLM ISO Abbreviation: Endocrinol Diabetes Nutr (Engl Ed) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Barcelona] : [Elsevier España], 2017-
مواضيع طبية MeSH: Hyponatremia*/diagnosis , Hyponatremia*/epidemiology , Hyponatremia*/etiology , Inappropriate ADH Syndrome*/drug therapy , Inappropriate ADH Syndrome*/etiology, Aged ; Female ; Humans ; Hypovolemia/complications ; Male ; Nausea/complications ; Pain ; Parenteral Nutrition, Total/adverse effects ; Prospective Studies
مستخلص: Background: In patients receiving total parenteral nutrition (TPN), the frequency of hyponatraemia is high. However, the causes of hyponatraemia in TPN have not been elucidated, although diagnosis is required for appropriate therapy. The aim of this study is to describe the aetiology of hyponatraemia in non-critical hospitalised patients receiving TPN.
Methods: Prospective multicentre study in 19 Spanish hospitals. Non-critically hyponatraemic patients receiving TPN and presenting hyponatraemia over a 9-month period were studied. Data collected included sex, age, previous comorbidities, and serum sodium levels (SNa) before and following TPN initiation. Parameters for study of hyponatraemia were also included: clinical volaemia, the presence of pain, nausea, gastrointestinal losses, diuretic use, oedema, renal function, plasma and urine osmolality, urinary electrolytes, cortisolaemia, and thyroid stimulating hormone.
Results: 162 patients were included, 53.7% males, age 66.4 (SD13.8) years. Volume status was evaluated in 142 (88%): 21 (14.8%) were hypovolaemic, 96 (67.6%) euvolaemic and 25 (17.6%) hypervolaemic. In 111/142 patients the analytical assessment of hyponatraemia was completed. Hypovolaemic hyponatraemia was secondary to GI losses in 10/111 (9%), and to diuretics in 3/111 (2.7%). Euvolaemic hyponatraemia was due to Syndrome of Inappropriate Antidiuretic Hormone secretion (SIADH) in 47/111 (42.4%), and to physiological stimuli of Arginine Vasopressin (AVP) secretion in 28/111 (25.2%). Hypervolaemic hyponatraemia was induced by heart failure in 19/111 (17.1%), cirrhosis of the liver in 4/111 (3.6%).
Conclusions: SIADH was the most frequent cause of hyponatraemia in patients receiving TPN. The second most frequent cause was physiological stimuli of AVP secretion induced by pain/nausea.
(Copyright © 2021 SEEN and SED. Published by Elsevier España, S.L.U. All rights reserved.)
فهرسة مساهمة: Keywords: Aetiology of hyponatraemia; Estímulo fisiológico de la secreción de AVP; Etiología de la hiponatremia; Nutrición parenteral; Parenteral nutrition; Physiological stimuli of AVP secretion; SIADH
تواريخ الأحداث: Date Created: 20220409 Date Completed: 20220412 Latest Revision: 20220412
رمز التحديث: 20240628
DOI: 10.1016/j.endien.2022.02.013
PMID: 35396114
قاعدة البيانات: MEDLINE
الوصف
تدمد:2530-0180
DOI:10.1016/j.endien.2022.02.013