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Dual Spinneret Electrospun Polyurethane/PVA-Gelatin Nanofibrous Scaffolds Containing Cinnamon Essential Oil and Nanoceria for Chronic Diabetic Wound Healing: Preparation, Physicochemical Characterization and In-Vitro Evaluation.

التفاصيل البيبلوغرافية
العنوان: Dual Spinneret Electrospun Polyurethane/PVA-Gelatin Nanofibrous Scaffolds Containing Cinnamon Essential Oil and Nanoceria for Chronic Diabetic Wound Healing: Preparation, Physicochemical Characterization and In-Vitro Evaluation.
المؤلفون: Hussein MAM; Clinic of Dermatology, University Hospital of RWTH Aachen, 52074 Aachen, Germany.; Department of Pharmacology, Medical Research Division, National Research Center, Dokki, Cairo 12622, Egypt., Gunduz O; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul 34722, Turkey.; Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul 34722, Turkey., Sahin A; Department of Biochemistry, School of Medicine, Marmara University, Istanbul 34854, Turkey.; Genetic and Metabolic Diseases Research and Investigation Center (GEMHAM), Marmara University, Istanbul 34854, Turkey., Grinholc M; Laboratory of Molecular Diagnostics, Department of Biotechnology, Intercollegiate Faculty of Biotechnology, University of Gdansk, 80307 Gdansk, Poland., El-Sherbiny IM; Nanomedicine Laboratory, Center for Materials Science (CMS), Zewail City of Science and Technology, 6th of October, Giza 12578, Egypt., Megahed M; Clinic of Dermatology, University Hospital of RWTH Aachen, 52074 Aachen, Germany.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2022 Mar 26; Vol. 27 (7). Date of Electronic Publication: 2022 Mar 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Diabetes Mellitus* , Nanofibers*/chemistry , Oils, Volatile*/chemistry , Oils, Volatile*/pharmacology, Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Cerium ; Cinnamomum zeylanicum ; Escherichia coli ; Gelatin/chemistry ; Humans ; Polyurethanes/pharmacology ; Polyvinyl Alcohol/chemistry ; Staphylococcus aureus ; Wound Healing
مستخلص: In this study, a dual spinneret electrospinning technique was applied to fabricate a series of polyurethane (PU) and polyvinyl alcohol-gelatin (PVA/Gel) nanofibrous scaffolds. The study aims to enhance the properties of PU/PVA-Gel NFs loaded with a low dose of nanoceria through the incorporation of cinnamon essential oil (CEO). The as-prepared nCeO 2 were embedded into the PVA/Gel nanofibrous layer, where the cinnamon essential oil (CEO) was incorporated into the PU nanofibrous layer. The morphology, thermal stability, mechanical properties, and chemical composition of the produced NF mats were investigated by STEM, DSC, and FTIR. The obtained results showed improvement in the mechanical, and thermal stability of the dual-fiber scaffolds by adding CEO along with nanoceria. The cytotoxicity evaluation revealed that the incorporation of CEO to PU/PVA-Gel loaded with a low dose of nanoceria could enhance the cell population compared to using pure PU/PVA-Gel NFs. Moreover, the presence of CEO could inhibit the growth rate of S. aureus more than E. coli . To our knowledge, this is the first time such nanofibrous membranes composed of PU and PVA-Gel have been produced. The first time was to load the nanofibrous membranes with both CEO and nCeO 2 . The obtained results indicate that the proposed PU/PVA-Gel NFs represent promising platforms with CEO and nCeO 2 for effectively managing diabetic wounds.
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معلومات مُعتمدة: Ref. 36/11207330, File No. 23/EGT/P34 Islamic Development Bank; 2018/30/Q/NZ7/00281 (M.G.) National Science Center in Poland
فهرسة مساهمة: Keywords: PU/PVA-gelatin-based nanofibrous scaffolds; diabetic wound healing; dual spinneret electrospinning; nanoceria
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Oils, Volatile)
0 (Polyurethanes)
30K4522N6T (Cerium)
619G5K328Y (ceric oxide)
9000-70-8 (Gelatin)
9002-89-5 (Polyvinyl Alcohol)
تواريخ الأحداث: Date Created: 20220412 Date Completed: 20220413 Latest Revision: 20230926
رمز التحديث: 20230926
مُعرف محوري في PubMed: PMC9000402
DOI: 10.3390/molecules27072146
PMID: 35408546
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules27072146