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Cardiometabolic risk factors in adults with normal weight obesity: A systematic review and meta-analysis.

التفاصيل البيبلوغرافية
العنوان: Cardiometabolic risk factors in adults with normal weight obesity: A systematic review and meta-analysis.
المؤلفون: Rakhmat II; Department of Biochemistry, Faculty of Medicine, Jenderal Achmad Yani University, Kota Cimahi, Jawa Barat, Indonesia., Putra ICS; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia., Wibowo A; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia., Henrina J; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia., Nugraha GI; Department of Basic Medical Science, Faculty of Medicine, Padjajadran University, Bandung, Indonesia., Ghozali M; Department of Basic Medical Science, Faculty of Medicine, Padjajadran University, Bandung, Indonesia., Syamsunarno MRAA; Department of Basic Medical Science, Faculty of Medicine, Padjajadran University, Bandung, Indonesia., Pranata R; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia., Akbar MR; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia., Achmad TH; Department of Basic Medical Science, Faculty of Medicine, Padjajadran University, Bandung, Indonesia.
المصدر: Clinical obesity [Clin Obes] 2022 Aug; Vol. 12 (4), pp. e12523. Date of Electronic Publication: 2022 Apr 12.
نوع المنشور: Journal Article; Meta-Analysis; Review; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101560587 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1758-8111 (Electronic) Linking ISSN: 17588103 NLM ISO Abbreviation: Clin Obes Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Wiley-Blackwell
مواضيع طبية MeSH: Diabetes Mellitus* , Hypertension*/epidemiology , Metabolic Syndrome*/epidemiology , Metabolic Syndrome*/etiology, Body Mass Index ; Cardiometabolic Risk Factors ; Cross-Sectional Studies ; Female ; Humans ; Male ; Obesity ; Risk Factors
مستخلص: Normal weight obesity (NWO) is a new emerging phenotype of obesity, defined as a normal body mass index with a high body fat percentage. While several studies have described the impact of NWO on cardiometabolic risk factors, the association between them remains uncertain. This meta-analysis systematically evaluated cardiometabolic risk factors in adults with NWO compared to adults with normal weight lean (NWL). A systematic literature search was performed from the inception until September 21, 2021 in order to comprehensively search for all observational studies that had three important variables, including adults (age ≥18 years old), NWO and cardiometabolic risk factors including metabolic syndrome, hypertension, diabetes mellitus, dyslipidaemia or all laboratory findings related to cardiometabolic risk factors. Twenty-four cross-sectional studies with a total of 75 201 subjects are included in the qualitative and quantitative analysis. Overall, older age and female sex are more likely in NWO population. Compared to NWL, NWO is significantly associated with cardiometabolic risk factors, including metabolic syndrome (OR = 2.24 [1.74, 2.89]; p < .001; I 2  = 76%, P heterogeneity  < 0.001), hypertension (OR = 1.60[1.36, 1.89]; p < .001; I 2  = 76%, P heterogeneity  < 0.001), diabetes mellitus (OR = 1.72[1.54, 1.92]; p < .001; I 2  = 47%, P heterogeneity  < 0.001), dyslipidaemia (OR = 1.50 [1.03, 2.18]; p = .03; I 2  = 94%, P heterogeneity  < 0.001) and other laboratory findings, except for C-reactive protein in both sexes group; and adiponectin levels in female group. Our meta-analysis showed that NWO was associated with cardiometabolic risk factors. Thus, the traditional definition of obesity using the BMI criteria should be challenged, as those with NWO might still be exposed to a heightened risk of cardiometabolic disorders. Nonetheless, further prospective cohort studies are needed better to understand this syndrome.
(© 2022 World Obesity Federation.)
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فهرسة مساهمة: Keywords: cardiometabolic risk factors; normal weight lean; normal weight obesity
تواريخ الأحداث: Date Created: 20220412 Date Completed: 20220718 Latest Revision: 20220718
رمز التحديث: 20240628
DOI: 10.1111/cob.12523
PMID: 35412026
قاعدة البيانات: MEDLINE
الوصف
تدمد:1758-8111
DOI:10.1111/cob.12523