دورية أكاديمية
Stone Age Yersinia pestis genomes shed light on the early evolution, diversity, and ecology of plague.
| العنوان: | Stone Age Yersinia pestis genomes shed light on the early evolution, diversity, and ecology of plague. |
|---|---|
| المؤلفون: | Andrades Valtueña A; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany., Neumann GU; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany., Spyrou MA; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.; Institute for Archaeological Sciences, Eberhard Karls University of Tübingen, 72074 Tübingen, Germany., Musralina L; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany.; Biology and Biotechnology Faculty, Al-Farabi Kazakh National University, 050040 Almaty, Kazakhstan.; Institute of Genetics and Physiology, Al-Farabi Kazakh National University, Almaty, 050060 Kazakhstan., Aron F; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany.; Faculty of Mathematics and Computer Science, Friedrich-Schiller University, 07743 Jena, Germany., Beisenov A; Begazy-Tasmola Research Center of History and Archeology, 050008 Almaty, Kazakhstan., Belinskiy AB; Nasledie Cultural Heritage Unit, 355006 Stavropol, Russian Federation., Bos KI; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany., Buzhilova A; Research Institute and Museum of Anthropology, Lomonosov Moscow State University, 125009 Moscow, Russian Federation., Conrad M; Department of Heritage Management, Archaeological Heritage Office Saxony, 01108 Dresden, Germany., Djansugurova LB; Institute of Genetics and Physiology, Al-Farabi Kazakh National University, Almaty, 050060 Kazakhstan., Dobeš M; Department of Prehistoric Archaeology, Institute of Archaeology, Czech Academy of Sciences, 11801 Prague, Czech Republic., Ernée M; Department of Prehistoric Archaeology, Institute of Archaeology, Czech Academy of Sciences, 11801 Prague, Czech Republic., Fernández-Eraso J; Department of Geography, Prehistory, and Archaeology, University of the Basque Country, Vitoria-Gasteiz, 01006 Spain., Frohlich B; Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560., Furmanek M; Institute of Archaeology, University of Wrocław, 50139 Wrocław, Poland., Hałuszko A; Institute of Archaeology, University of Wrocław, 50139 Wrocław, Poland.; Archeolodzy.org Foundation, 50316 Wrocław, Poland., Hansen S; Eurasia-Department, German Archaeological Institute, 14195 Berlin, Germany., Harney É; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Hiss AN; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany., Hübner A; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.; Faculty of Biological Sciences, Friedrich-Schiller University, 07743 Jena, Germany., Key FM; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.; Evolutionary Pathogenomics, Max Planck Institute for Infection Biology, 10117 Berlin, Germany., Khussainova E; Institute of Genetics and Physiology, Al-Farabi Kazakh National University, Almaty, 050060 Kazakhstan., Kitov E; Institute of Ethnology and Anthropology, Russian Academy of Science, 119991 Moscow, Russian Federation.; Research Laboratory of Paleoanthropological Study, Institute of Archaeology named after A.Kh Margulan, Almaty, 50010 Kazakhstan.; History Department, Al-Farabi Kazakh National University, 050040 Almaty, Kazakhstan., Kitova AO; Centre for Egyptological Studies of the Russian Academy of Sciences, Russian Academy of Sciences, 119991 Moscow, Russian Federation., Knipper C; Curt Engelhorn Center Archaeometry, 68159 Mannheim, Germany., Kühnert D; Transmission, Infection, Diversification & Evolution Group, Max Planck Institute for the Science of Human History, 07745 Jena, Germany., Lalueza-Fox C; Institute of Evolutionary Biology, Consejo Superior de Investigaciones Cientificas-Universitat Pompeu Fabra, 08003 Barcelona, Spain., Littleton J; Department of Anthropology, University of Auckland, 01010 Auckland, New Zealand., Massy K; Institute for Pre- and Protohistoric Archaeology and Archaeology of the Roman Provinces, Ludwig Maximilian University Munich, 80539 Munich, Germany., Mittnik A; Department of Genetics, Harvard Medical School, Boston, MA 02115.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138., Mujika-Alustiza JA; Department of Geography, Prehistory, and Archaeology, University of the Basque Country, Vitoria-Gasteiz, 01006 Spain., Olalde I; Department of Genetics, Harvard Medical School, Boston, MA 02115.; Institute of Evolutionary Biology, Consejo Superior de Investigaciones Cientificas-Universitat Pompeu Fabra, 08003 Barcelona, Spain.; BIOMICs Research Group, University of the Basque Country Universidad del Pais Vasco/Euskal Herriko Unibertsitatea, 01006 Vitoria-Gasteiz, Spain., Papac L; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany., Penske S; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany., Peška J; Archaeological Centre, 779 00 Olomouc, Czech Republic., Pinhasi R; Department of Evolutionary Anthropology, University of Vienna, 1030 Vienna, Austria., Reich D; Department of Genetics, Harvard Medical School, Boston, MA 02115.; Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138., Reinhold S; Eurasia-Department, German Archaeological Institute, 14195 Berlin, Germany., Stahl R; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany., Stäuble H; Department of Heritage Management, Archaeological Heritage Office Saxony, 01108 Dresden, Germany., Tukhbatova RI; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, 07745 Jena, Germany.; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, 420008 Russian Federation.; Laboratory for Structural Analysis of Biomacromolecules, Federal Research Center 'Kazan Scientific Center of the Russian Academy of Sciences', 420111 Kazan, Russian Federation., Vasilyev S; Institute of Ethnology and Anthropology, Russian Academy of Science, 119991 Moscow, Russian Federation., Veselovskaya E; Institute of Ethnology and Anthropology, Russian Academy of Science, 119991 Moscow, Russian Federation., Warinner C; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.; Faculty of Biological Sciences, Friedrich-Schiller University, 07743 Jena, Germany.; Department of Anthropology, Harvard University, Cambridge, MA 02138., Stockhammer PW; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.; Institute for Pre- and Protohistoric Archaeology and Archaeology of the Roman Provinces, Ludwig Maximilian University Munich, 80539 Munich, Germany., Haak W; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany., Krause J; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany., Herbig A; Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Apr 26; Vol. 119 (17), pp. e2116722119. Date of Electronic Publication: 2022 Apr 11. |
| نوع المنشور: | Historical Article; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Genome, Bacterial* , Plague*/epidemiology , Plague*/history , Plague*/microbiology , Yersinia pestis*/classification , Yersinia pestis*/genetics , Yersinia pestis*/isolation & purification, Animal Husbandry/history ; Animals ; DNA, Ancient ; Genetic Variation ; History, Ancient ; Human Migration/history ; Humans ; Phylogeny |
| مستخلص: | The bacterial pathogen Yersinia pestis gave rise to devastating outbreaks throughout human history, and ancient DNA evidence has shown it afflicted human populations as far back as the Neolithic. Y. pestis genomes recovered from the Eurasian Late Neolithic/Early Bronze Age (LNBA) period have uncovered key evolutionary steps that led to its emergence from a Yersinia pseudotuberculosis-like progenitor; however, the number of reconstructed LNBA genomes are too few to explore its diversity during this critical period of development. Here, we present 17 Y. pestis genomes dating to 5,000 to 2,500 y BP from a wide geographic expanse across Eurasia. This increased dataset enabled us to explore correlations between temporal, geographical, and genetic distance. Our results suggest a nonflea-adapted and potentially extinct single lineage that persisted over millennia without significant parallel diversification, accompanied by rapid dispersal across continents throughout this period, a trend not observed in other pathogens for which ancient genomes are available. A stepwise pattern of gene loss provides further clues on its early evolution and potential adaptation. We also discover the presence of the flea-adapted form of Y. pestis in Bronze Age Iberia, previously only identified in in the Caucasus and the Volga regions, suggesting a much wider geographic spread of this form of Y. pestis. Together, these data reveal the dynamic nature of plague’s formative years in terms of its early evolution and ecology. |
| التعليقات: | Comment in: Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2204044119. (PMID: 35580179) |
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| فهرسة مساهمة: | Keywords: Yersinia pestis; ancient DNA; plague |
| المشرفين على المادة: | 0 (DNA, Ancient) |
| تواريخ الأحداث: | Date Created: 20220412 Date Completed: 20220414 Latest Revision: 20220716 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC9169917 |
| DOI: | 10.1073/pnas.2116722119 |
| PMID: | 35412864 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
|---|---|
| DOI: | 10.1073/pnas.2116722119 |