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Restorative Action of Vitamin D3 on Motor Dysfunction Through Enhancement of Neurotrophins and Antioxidant Expression in the Striatum.

التفاصيل البيبلوغرافية
العنوان: Restorative Action of Vitamin D3 on Motor Dysfunction Through Enhancement of Neurotrophins and Antioxidant Expression in the Striatum.
المؤلفون: Manjari SKV; Department of Biological Sciences, Birla Institute of Technology and Sciences (BITS)-Pilani (Hyderabad Campus), Shameerpet-Mandal, Hyderabad, Telangana 500078, India. Electronic address: p20180002@hyderabad.bits-pilani.ac.in., Maity S; Department of Biological Sciences, Birla Institute of Technology and Sciences (BITS)-Pilani (Hyderabad Campus), Shameerpet-Mandal, Hyderabad, Telangana 500078, India. Electronic address: shuvadeep@hyderabad.bits-pilani.ac.in., Poornima R; Department of Biological Sciences, Birla Institute of Technology and Sciences (BITS)-Pilani (Hyderabad Campus), Shameerpet-Mandal, Hyderabad, Telangana 500078, India. Electronic address: h20191290063@hyderabad.bits-pilani.ac.in., Yau SY; Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, 11 Yuk Choi Road, Hung Hom, Kowloon, Hong Kong Special Administrative Region. Electronic address: sonata.yau@polyu.edu.hk., Vaishali K; Department of Biological Sciences, Birla Institute of Technology and Sciences (BITS)-Pilani (Hyderabad Campus), Shameerpet-Mandal, Hyderabad, Telangana 500078, India. Electronic address: p20200006@hyderabad.bits-pilani.ac.in., Stellwagen D; Department of Neurology and Neurosurgery, Centre for Research in Neuroscience, Research Institute of the McGill University Health Center, Montréal, QC, Canada. Electronic address: david.stellwagen@mcgill.ca., Komal P; Department of Biological Sciences, Birla Institute of Technology and Sciences (BITS)-Pilani (Hyderabad Campus), Shameerpet-Mandal, Hyderabad, Telangana 500078, India. Electronic address: pragya@hyderabad.bits-pilani.ac.in.
المصدر: Neuroscience [Neuroscience] 2022 Jun 01; Vol. 492, pp. 67-81. Date of Electronic Publication: 2022 Apr 10.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE
أسماء مطبوعة: Publication: [New York?] : Elsevier Science
Original Publication: Oxford, Elmsford, N. Y., Pergamon Press
مواضيع طبية MeSH: Antioxidants*/metabolism , Huntington Disease*/metabolism, Animals ; Cholecalciferol/adverse effects ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Growth Factors ; Nitro Compounds ; Propionates ; Rats ; Rats, Wistar
مستخلص: A number of studies has explored a positive correlation between low levels of serum Vitamin D 3 (VD; cholecalciferol) and development of neurodegenerative diseases including Huntington's disease (HD). In the present study, the prophylactic effect of VD on motor dysfunction was studied in an experimental model of HD. An HD-like syndrome was induced in male C57BL/6 mice through an intraperitoneal injection (i.p) of 3-NP for 3 consecutive doses at 12 h interval of time as described previously (Amende et al. 2005). This study investigated thein-vivotherapeutic potential of VD (500 IU/kg/day) supplementation on movement, motor coordination, motor activity and biochemical changes in this HD model. Mice were divided into four groups: Group I: Control (saline); Group II: 3-NP induced HD (HD); Group III: Vitamin D 3 (VD) and Group IV: 3-NP induced + post Vitamin D 3 injection (HD + VD). All groups of mice were tested for locomotion, gait analysis and rotarod performances over a span of 30-days. VD administration rescued locomotor dysfunction and neuromuscular impairment in HD mice with no change in gait dynamics. In addition, administration of VD to 3-NP treated mice led to a significant enhancement in the expression of key neurotrophic factors including brain-derived neurotrophic factor (BDNF) and nerve-growth factor (NGF), the Vitamin D receptor (VDR), and antioxidant markers (catalases [Cat] and glutathione peroxidase [GpX4]) in the striatum, suggesting a detoxification effect of VD. Altogether, our results show that VD supplementation induces survival signals, diminishes oxidative stress, and reduces movement and motor dysfunction in HD.
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فهرسة مساهمة: Keywords: 3-nitropropionic acid (3-NP); Huntington’s disease (HD); antioxidants; cholecalciferol; neurotrophic factors; vitamin D(3) (VD)
المشرفين على المادة: 0 (Antioxidants)
0 (Nerve Growth Factors)
0 (Nitro Compounds)
0 (Propionates)
1C6V77QF41 (Cholecalciferol)
تواريخ الأحداث: Date Created: 20220412 Date Completed: 20220524 Latest Revision: 20220531
رمز التحديث: 20221213
DOI: 10.1016/j.neuroscience.2022.03.039
PMID: 35413386
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-7544
DOI:10.1016/j.neuroscience.2022.03.039