دورية أكاديمية
Coumarin derivatives as inhibitors of d-amino acid oxidase and monoamine oxidase.
العنوان: | Coumarin derivatives as inhibitors of d-amino acid oxidase and monoamine oxidase. |
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المؤلفون: | Bester E; Pharmaceutical Chemistry, School of Pharmacy and Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa. Electronic address: elizabethbesternwu@gmail.com., Petzer A; Pharmaceutical Chemistry, School of Pharmacy and Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa. Electronic address: 12264954@nwu.ac.za., Petzer JP; Pharmaceutical Chemistry, School of Pharmacy and Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom 2520, South Africa. Electronic address: jacques.petzer@nwu.ac.za. |
المصدر: | Bioorganic chemistry [Bioorg Chem] 2022 Jun; Vol. 123, pp. 105791. Date of Electronic Publication: 2022 Apr 06. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
مواضيع طبية MeSH: | Monoamine Oxidase*/metabolism , Parkinson Disease*, Amino Acids ; Animals ; Coumarins/pharmacology ; Dose-Response Relationship, Drug ; Monoamine Oxidase Inhibitors/chemistry ; Monoamine Oxidase Inhibitors/pharmacology ; Receptors, N-Methyl-D-Aspartate ; Serine ; Structure-Activity Relationship ; Swine |
مستخلص: | d-Amino acid oxidase (DAAO) oxidises d-amino acids to ultimately produce the corresponding α-keto acids. The DAAO substrate, d-serine, is a co-agonist at NMDA receptors, while NMDA receptor hypo-function has been implicated in the pathophysiology of schizophrenia. Through the modulation of d-serine levels, the inhibition of DAAO represents a strategy to increase NMDA receptor function, and thus a potential treatment for schizophrenia. Literature reports that 3-hydroxycoumarin is a potent inhibitor of DAAO and represents an ideal lead for the development of novel DAAO inhibitors. Based on this, the present study investigated DAAO inhibition by a series of synthetic and commercially available coumarin derivatives. Due to structural similarity to coumarin, a synthetic series of 3,4-dihydroisoquinolin-1(2H)-one derivatives has also been included in this study. The results show that among 37 compound evaluated, four inhibit porcine kidney DAAO with IC (Copyright © 2022 Elsevier Inc. All rights reserved.) |
فهرسة مساهمة: | Keywords: Coumarin; D-amino acid oxidase; Depression; Monoamine oxidase; Parkinson’s disease; Schizophrenia |
المشرفين على المادة: | 0 (Amino Acids) 0 (Coumarins) 0 (Monoamine Oxidase Inhibitors) 0 (Receptors, N-Methyl-D-Aspartate) 452VLY9402 (Serine) EC 1.4.3.4 (Monoamine Oxidase) |
تواريخ الأحداث: | Date Created: 20220412 Date Completed: 20220502 Latest Revision: 20220508 |
رمز التحديث: | 20221213 |
DOI: | 10.1016/j.bioorg.2022.105791 |
PMID: | 35413582 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1090-2120 |
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DOI: | 10.1016/j.bioorg.2022.105791 |