دورية أكاديمية
أعرض في EDS

The phytoactive constituents of Eugenia selloi B.D. Jacks (pitangatuba): Toxicity and elucidation of their anti-inflammatory mechanism(s) of action.

التفاصيل البيبلوغرافية
العنوان: The phytoactive constituents of Eugenia selloi B.D. Jacks (pitangatuba): Toxicity and elucidation of their anti-inflammatory mechanism(s) of action.
المؤلفون: Lazarini JG; Department of Biosciences, Piracicaba Dental School, University of Campinas, Limeira Avenue, 901, Areião, 13414-903 Piracicaba, SP, Brazil., Massarioli AP; Department of Agri-Food Industry, Food and Nutrition, 'Luiz de Queiroz' College of Agriculture, University of São Paulo, Pádua Dias Avenue, P.O. Box. 9, 13418-900 Piracicaba, SP, Brazil., Soares JC; Department of Agri-Food Industry, Food and Nutrition, 'Luiz de Queiroz' College of Agriculture, University of São Paulo, Pádua Dias Avenue, P.O. Box. 9, 13418-900 Piracicaba, SP, Brazil., Nani BD; Department of Biosciences, Piracicaba Dental School, University of Campinas, Limeira Avenue, 901, Areião, 13414-903 Piracicaba, SP, Brazil., Charo N; Laboratory of Experimental Thrombosis, Institute of Experimental Medicine, CONICET, National Academy of Medicine, 1425 Buenos Aires, Argentina., Oliveira DS; Centre of Excellence in New Target Discovery (CENTD), Development and Innovation Laboratory, Butantan Institute, São Paulo, SP, Brazil., Camargo L; Centre of Excellence in New Target Discovery (CENTD), Development and Innovation Laboratory, Butantan Institute, São Paulo, SP, Brazil., Alvarez-Flores MP; Centre of Excellence in New Target Discovery (CENTD), Development and Innovation Laboratory, Butantan Institute, São Paulo, SP, Brazil., Batista IFC; Centre of Excellence in New Target Discovery (CENTD), Development and Innovation Laboratory, Butantan Institute, São Paulo, SP, Brazil., Chudzinski-Tavassi AM; Centre of Excellence in New Target Discovery (CENTD), Development and Innovation Laboratory, Butantan Institute, São Paulo, SP, Brazil., Alencar SM; Department of Agri-Food Industry, Food and Nutrition, 'Luiz de Queiroz' College of Agriculture, University of São Paulo, Pádua Dias Avenue, P.O. Box. 9, 13418-900 Piracicaba, SP, Brazil., Franchin M; Department of Biosciences, Piracicaba Dental School, University of Campinas, Limeira Avenue, 901, Areião, 13414-903 Piracicaba, SP, Brazil.; Faculty of Dentistry, Federal University of Alfenas, Alfenas, MG, Brazil., Rosalen PL; Department of Biosciences, Piracicaba Dental School, University of Campinas, Limeira Avenue, 901, Areião, 13414-903 Piracicaba, SP, Brazil.; Biological Sciences Graduate Program, Federal University of Alfenas, Alfenas, MG, Brazil.
المصدر: Food chemistry. Molecular sciences [Food Chem (Oxf)] 2022 Mar 07; Vol. 4, pp. 100093. Date of Electronic Publication: 2022 Mar 07 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 9918367084406676 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-5662 (Electronic) Linking ISSN: 26665662 NLM ISO Abbreviation: Food Chem (Oxf) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: [Oxford] : Elsevier Ltd., [2020]-
مستخلص: We determined the phytochemical composition, anti-inflammatory mechanism of action, ROS/RNS scavenging capacity and systemic toxicity of a purified subfraction (S8) of Eugenia selloi . The composition of S8 was assessed by LC-ESI-QTOF-MS; the anti-inflammatory activity in RAW264.7 macrophages through NF-κB activation and biomarkers by multiplex in THP-1 cells; neutrophil migration, intravital microscopy and ICAM-1 expression in mice; NETs formation and CD11b expression; S8 scavenging capacity of ROS/RNS; toxicity in Galleria mellonella larvae model. Coumaric acid, quercetrin and vanillic acid were identified. S8 decreased NF-κB activation, IL-1β, IL-6, IL-10, MDC and MCP-1 levels, reduced neutrophil migration and ICAM-1 expression in mice; S8 did not interfere NET formation and CD11b expression, exhibited high antioxidant and showed negligible toxicity. E. selloi proved to be a promising, yet underexplored source of bioactive compounds, which can be useful employed in agribusiness and in the pharmaceutical and food industry to develop new products or human health supplies.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2022 The Authors.)
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فهرسة مساهمة: Keywords: Anti-inflammatory; Eugenia selloi; Native fruit; ROS and RNS
تواريخ الأحداث: Date Created: 20220413 Latest Revision: 20220414
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8991978
DOI: 10.1016/j.fochms.2022.100093
PMID: 35415693
قاعدة البيانات: MEDLINE
الوصف
تدمد:2666-5662
DOI:10.1016/j.fochms.2022.100093