دورية أكاديمية
أعرض في EDS

Assessment of the Oxidative Damage and Genotoxicity of Titanium Dioxide Nanoparticles and Exploring the Protective Role of Holy Basil Oil Nanoemulsions in Rats.

التفاصيل البيبلوغرافية
العنوان: Assessment of the Oxidative Damage and Genotoxicity of Titanium Dioxide Nanoparticles and Exploring the Protective Role of Holy Basil Oil Nanoemulsions in Rats.
المؤلفون: Sallam MF; Pharmacology and Toxicology Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt., Ahmed HMS; Toxicology & Pharmacology Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. helmy-moawad@yahoo.com., El-Nekeety AA; Food Toxicology & Contaminants Department, National Research Center, Dokki, Cairo, Egypt., Diab KA; Genetics and Cytology Department, National Research Center, Dokki, Cairo, Egypt., Abdel-Aziem SH; Cell Biology Department, National Research Center, Dokki, Cairo, Egypt., Sharaf HA; Pathology Department, National Research Center, Dokki, Cairo, Egypt., Abdel-Wahhab MA; Food Toxicology & Contaminants Department, National Research Center, Dokki, Cairo, Egypt. mosaad_abdelwahhab@yahoo.com.
المصدر: Biological trace element research [Biol Trace Elem Res] 2023 Mar; Vol. 201 (3), pp. 1301-1316. Date of Electronic Publication: 2022 Apr 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 7911509 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0720 (Electronic) Linking ISSN: 01634984 NLM ISO Abbreviation: Biol Trace Elem Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London, Clifton, N. J.] Humana Press.
مواضيع طبية MeSH: Nanoparticles*/toxicity , Metal Nanoparticles*/toxicity, Rats ; Male ; Animals ; Titanium/toxicity ; Rats, Sprague-Dawley ; Ocimum sanctum ; Oxidative Stress ; DNA Damage
مستخلص: This study was designed to evaluate the oxidative damage, genotoxicity, and DNA damage in the liver of rats treated with titanium nanoparticles (TiO 2 -NPs) with an average size of 28.0 nm and ξ-potential of - 33.97 mV, and to estimate the protective role of holy basil essential oil nanoemulsion (HBEON). Six groups of Male Sprague-Dawley rats were treated orally for 3 weeks as follows: the control group, HBEO or HBEON-treated groups (5 mg/kg b.w), TiO 2 -NPs-treated group (50 mg/kg b.w), and the groups treated with TiO 2 -NPs plus HBEO or HBEON. Samples of blood and tissues were collected for different analyses. The results revealed that 55 compounds were identified in HBEO, and linalool and methyl chavicol were the major compounds (53.9%, 12.63%, respectively). HBEON were semi-round with the average size and ζ-potential of 120 ± 4.5 nm and - 28 ± 1.3 mV, respectively. TiO 2 -NP administration increased the serum biochemical indices, oxidative stress markers, serum cytokines, DNA fragmentation, and DNA breakages; decreased the antioxidant enzymes; and induced histological alterations in the liver. Co-administration of TiO 2 -NPs plus HBEO or HBEON improved all the tested parameters and the liver histology, and HBEON was more effective than HBEO. Therefore, HEBON is a promising candidate able to protect against oxidative damage, disturbances in biochemical markers, gene expression, DNA damage, and histological changes resulting from exposure to TiO 2 -NPs and may be applicable in the food and pharmaceutical sectors.
(© 2022. The Author(s).)
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معلومات مُعتمدة: 12050305 National Research Centre
فهرسة مساهمة: Keywords: Antioxidant; Basil essential oil; Genotoxicity; Nanoemulsions; Oxidative damage; Titanium dioxide nanoparticles
المشرفين على المادة: 15FIX9V2JP (titanium dioxide)
D1JT611TNE (Titanium)
تواريخ الأحداث: Date Created: 20220413 Date Completed: 20230207 Latest Revision: 20230207
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9898350
DOI: 10.1007/s12011-022-03228-0
PMID: 35416606
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-0720
DOI:10.1007/s12011-022-03228-0