دورية أكاديمية
Interactions between Loci Contributing to Antimicrobial Resistance and Virulence in Neisseria gonorrhoeae.
| العنوان: | Interactions between Loci Contributing to Antimicrobial Resistance and Virulence in Neisseria gonorrhoeae. |
|---|---|
| المؤلفون: | Mortimer TD; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. |
| المصدر: | MBio [mBio] 2022 Jun 28; Vol. 13 (3), pp. e0041222. Date of Electronic Publication: 2022 Apr 14. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Comment |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Society for Microbiology |
| مواضيع طبية MeSH: | Drug Resistance, Bacterial*/genetics , Neisseria gonorrhoeae*/drug effects , Neisseria gonorrhoeae*/pathogenicity , Virulence*/genetics, Anti-Bacterial Agents/pharmacology ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Gene Expression Regulation, Bacterial ; Microbial Sensitivity Tests ; Repressor Proteins/genetics ; Repressor Proteins/metabolism |
| مستخلص: | In a recent mBio article, Ayala et al. (mBio 13:e00276-22, 2022, https://doi.org/10.1128/mbio.00276-22) identified a single nucleotide variant in the repressor gdhR in Neisseria gonorrhoeae that reduces binding to the promoter of the virulence factor lctP and thereby increases its expression. The allele ( gdhR6 ) frequently co-occurs with mutations in the mtr operon promoter that reduce expression of another repressor, mtrR , resulting in overexpression of the efflux pump-encoding mtrCDE and increased antimicrobial resistance. Because mtrR also represses gdhR , a decline in mtrR would decrease expression of lctP. Hypothesizing that gdhR6 arose to circumvent the impact of mtrR promoter mutations on lctP expression, the authors analyzed these loci in genomes of N. gonorrhoeae isolates from the preantibiotic era. Surprisingly, they found isolates with gdhR6 prior to selection for mtrR resistance-associated alleles. These results suggest that independent and perhaps interacting pressures have influenced the co-occurrence of these alleles. |
| التعليقات: | Comment on: mBio. 2022 Apr 26;13(2):e0027622. (PMID: 35258329) |
| References: | Mol Microbiol. 2008 Oct;70(2):462-78. (PMID: 18761689) Microbiology (Reading). 1995 Apr;141 ( Pt 4):907-11. (PMID: 7773394) J Bacteriol. 1995 Jul;177(14):4162-5. (PMID: 7608095) mBio. 2022 Apr 26;13(2):e0027622. (PMID: 35258329) Infect Immun. 2007 Mar;75(3):1318-24. (PMID: 17158905) mBio. 2017 Apr 11;8(2):. (PMID: 28400529) Nat Microbiol. 2019 Nov;4(11):1941-1950. (PMID: 31358980) Sex Transm Dis. 2021 Aug 1;48(8S):S78-S87. (PMID: 33993166) BMC Genomics. 2020 Feb 3;21(1):116. (PMID: 32013864) Nat Commun. 2020 Aug 17;11(1):4126. (PMID: 32807804) PLoS Pathog. 2019 Dec 20;15(12):e1008233. (PMID: 31860664) |
| معلومات مُعتمدة: | F32 AI145157 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: Neisseria gonorrhoeae; antibiotic resistance; gonorrhea; virulence factors |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Bacterial Proteins) 0 (Repressor Proteins) |
| تواريخ الأحداث: | Date Created: 20220414 Date Completed: 20220630 Latest Revision: 20220716 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9239038 |
| DOI: | 10.1128/mbio.00412-22 |
| PMID: | 35420483 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2150-7511 |
|---|---|
| DOI: | 10.1128/mbio.00412-22 |