دورية أكاديمية
أعرض في EDS

Drug-loaded mesoporous silica on carboxymethyl cellulose hydrogel: Development of innovative 3D printed hydrophilic films.

التفاصيل البيبلوغرافية
العنوان: Drug-loaded mesoporous silica on carboxymethyl cellulose hydrogel: Development of innovative 3D printed hydrophilic films.
المؤلفون: Schmidt LM; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Dos Santos J; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., de Oliveira TV; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Funk NL; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Petzhold CL; Institute of Chemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Benvenutti EV; Institute of Chemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil., Deon M; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil; Departamento de Farmacociências, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil. Electronic address: monique.deon@ufcspa.edu.br., Beck RCR; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: ruy.beck@ufrgs.br.
المصدر: International journal of pharmaceutics [Int J Pharm] 2022 May 25; Vol. 620, pp. 121750. Date of Electronic Publication: 2022 Apr 12.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7804127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3476 (Electronic) Linking ISSN: 03785173 NLM ISO Abbreviation: Int J Pharm Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Carboxymethylcellulose Sodium* , Hydrogels*, Drug Liberation ; Printing, Three-Dimensional ; Silicon Dioxide/chemistry ; Solubility ; Triamcinolone Acetonide ; Water/chemistry
مستخلص: 3D printing has been explored as an emerging technology for the development of versatile and printable materials for drug delivery. However, the alliance of 3D printing and nanomaterials has, to date, been little explored in pharmaceutics. Herein, a mesoporous silica with nanostructured pores, SBA-15, was used as a drug carrier for triamcinolone acetonide, a hydrophobic drug, with the aim of incorporating the drug formulation in a hydrophilic printable ink. The adsorption of the drug in the SBA-15 pores was confirmed by the decrease in its surface area and pore volume, along with an increase in the apparent aqueous solubility of triamcinolone acetonide, as shown by in vitro release studies. Thereafter, a hydrophilic ink composed of carboxymethyl cellulose containing drug-loaded SBA-15 was formulated and 3D printed as hydrophilic polymeric film using the semisolid extrusion technique (SSE). The 3D printed films showed complete drug release after 12 h, and the presence of the triamcinolone acetonide-loaded SBA-15 improved their in vitro mucoadhesion, suggesting their promising application in oral mucosa treatments. Besides representing an innovative platform to develop water-based mucoadhesive formulations containing a hydrophobic drug, this is the first report proposing the development of SSE 3D printed nanomedicines containing drug-loaded mesoporous silica.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Additive manufacturing; Dissolution enhancement; Nanomedicine; Nanostructured silica; Semisolid extrusion; Solid dosage form
المشرفين على المادة: 0 (Hydrogels)
059QF0KO0R (Water)
7631-86-9 (Silicon Dioxide)
F446C597KA (Triamcinolone Acetonide)
K679OBS311 (Carboxymethylcellulose Sodium)
تواريخ الأحداث: Date Created: 20220414 Date Completed: 20220517 Latest Revision: 20220517
رمز التحديث: 20240628
DOI: 10.1016/j.ijpharm.2022.121750
PMID: 35421531
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3476
DOI:10.1016/j.ijpharm.2022.121750