دورية أكاديمية
أعرض في EDS

A Nomogram for Predicting Event-Free Survival in Childhood Acute Lymphoblastic Leukemia: A Multicenter Retrospective Study.

التفاصيل البيبلوغرافية
العنوان: A Nomogram for Predicting Event-Free Survival in Childhood Acute Lymphoblastic Leukemia: A Multicenter Retrospective Study.
المؤلفون: He YY; Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China., Wu XJ; Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.; Graduate School, Guangxi Medical University, Nanning, China., Zhou DH; Children's Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Yang LH; Department of Pediatrics, Southern Medical University Zhujiang Hospital, Guangzhou, China., Mai HR; Department of Hematology and Oncology, Shenzhen Children's Hospital, Shenzhen, China., Wan WQ; Department of Pediatrics, Second Xiangya Hospital of Central South University, Changsha, China., Luo XQ; Department of Pediatrics, Sun Yat-Sen University First Affiliated Hospital, Guangzhou, China., Zheng MC; Department of Hematology, Hunan Children's Hospital, Changsha, China., Zhang JL; Graduate School, Guangxi Medical University, Nanning, China., Ye ZL; Department of Pediatrics, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China., Chen HQ; Department of Pediatrics, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China., Chen QW; Department of Pediatrics, First Affiliated Hospital of Nanchang University, Nanchang, China., Long XJ; Department of Pediatrics, Liuzhou People's Hospital, Liuzhou, China., Sun XF; Department of Pediatrics, Sun Yat-Sen University Cancer Center, Guangzhou, China., Liu RY; Department of Pediatrics, Huizhou Central People's Hospital, Huizhou, China., Li QR; Department of Pediatrics, Zhongshan People's Hospital, Zhongshan, China., Wu BY; Department of Pediatrics, The First Affiliated Hospital of Shantou University Medical College, Shantou, China., Wang LN; Department of Pediatrics, Guangzhou First People's Hospital, Guangzhou, China., Kong XL; Department of Pediatrics, Boai Hospital of Zhongshan, Zhongshan, China., Chen GH; Department of Pediatrics, Huizhou First People's Hospital, Huizhou, China., Tang XY; School of Public Health, Guangxi Medical University, Nanning, China., Fang JP; Children's Medical Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China., Liao N; Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
المصدر: Frontiers in oncology [Front Oncol] 2022 Mar 29; Vol. 12, pp. 854798. Date of Electronic Publication: 2022 Mar 29 (Print Publication: 2022).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مستخلص: Objective: Even though childhood acute lymphoblastic leukemia (ALL) has an encouraging survival rate in recent years, some patients are still at risk of relapse or even death. Therefore, we aimed to construct a nomogram to predict event-free survival (EFS) in patients with ALL.
Method: Children with newly diagnosed ALL between October 2016 and July 2021 from 18 hospitals participating in the South China children's leukemia Group (SCCLG) were recruited and randomly classified into two subsets in a 7:3 ratio (training set, n=1187; validation set, n=506). Least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analysis were adopted to screen independent prognostic factors. Then, a nomogram can be build based on these prognostic factors to predict 1-, 2-, and 3-year EFS. Concordance index (C-index), area under the curve (AUC), calibration curve, and decision curve analysis (DCA) were used to evaluate the performance and clinical utility of nomogram.
Result: The parameters that predicted EFS were age at diagnosis, white blood cell at diagnosis, immunophenotype, ETV6-RUNX1/TEL-AML1 gene fusion, bone marrow remission at day 15, and minimal residual disease at day 15. The nomogram incorporated the six factors and provided C-index values of 0.811 [95% confidence interval (CI) = 0.792-0.830] and 0.797 (95% CI = 0.769-0.825) in the training and validation set, respectively. The calibration curve and AUC revealed that the nomogram had good ability to predict 1-, 2-, and 3-year EFS. DCA also indicated that our nomogram had good clinical utility. Kaplan-Meier analysis showed that EFS in the different risk groups stratified by the nomogram scores was significant differentiated.
Conclusion: The nomogram for predicting EFS of children with ALL has good performance and clinical utility. The model could help clinical decision-making.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2022 He, Wu, Zhou, Yang, Mai, Wan, Luo, Zheng, Zhang, Ye, Chen, Chen, Long, Sun, Liu, Li, Wu, Wang, Kong, Chen, Tang, Fang and Liao.)
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فهرسة مساهمة: Keywords: childhood acute lymphoblastic leukemia; event-free survival; multicenter retrospective study; nomogram; prognostic factor
تواريخ الأحداث: Date Created: 20220415 Latest Revision: 20220423
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9002097
DOI: 10.3389/fonc.2022.854798
PMID: 35425700
قاعدة البيانات: MEDLINE
الوصف
تدمد:2234-943X
DOI:10.3389/fonc.2022.854798