دورية أكاديمية
The Val16Ala MnSOD gene polymorphism is associated with hypertension in self-declared black individuals.
| العنوان: | The Val16Ala MnSOD gene polymorphism is associated with hypertension in self-declared black individuals. |
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| المؤلفون: | Berro LF; Federal University of Pampa - Campus Uruguaiana, Uruguaiana, Brazil.; Postgraduate Program in Biochemistry, Federal University of Pampa, Campus Uruguaiana, Uruguaiana, Brazil., Maurer P; Federal University of Pampa - Campus Uruguaiana, Uruguaiana, Brazil.; Postgraduate Program in Biochemistry, Federal University of Pampa, Campus Uruguaiana, Uruguaiana, Brazil., Rubio D; Federal University of Pampa - Campus Uruguaiana, Uruguaiana, Brazil.; Course of Pharmacy, Federal University of Pampa - Campus Uruguaiana, Uruguaiana, Brazil., Retamoso V; Federal University of Pampa - Campus Uruguaiana, Uruguaiana, Brazil.; Postgraduate Program in Biochemistry, Federal University of Pampa, Campus Uruguaiana, Uruguaiana, Brazil., Santos L; Federal University of Pampa - Campus Uruguaiana, Uruguaiana, Brazil., Manfredini V; Federal University of Pampa - Campus Uruguaiana, Uruguaiana, Brazil.; Postgraduate Program in Biochemistry, Federal University of Pampa, Campus Uruguaiana, Uruguaiana, Brazil.; Course of Pharmacy, Federal University of Pampa - Campus Uruguaiana, Uruguaiana, Brazil., Piccoli JDCE; Federal University of Pampa - Campus Uruguaiana, Uruguaiana, Brazil.; Postgraduate Program in Biochemistry, Federal University of Pampa, Campus Uruguaiana, Uruguaiana, Brazil.; Course of Pharmacy, Federal University of Pampa - Campus Uruguaiana, Uruguaiana, Brazil. |
| المصدر: | Free radical research [Free Radic Res] 2022 Feb; Vol. 56 (2), pp. 154-162. Date of Electronic Publication: 2022 Apr 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9423872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2470 (Electronic) Linking ISSN: 10292470 NLM ISO Abbreviation: Free Radic Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Yverdon, Switzerland : New York, NY : Harwood Academic ; distributed by STBS Ltd., c1994- |
| مواضيع طبية MeSH: | Hypertension*/genetics , Serum Albumin*/genetics, Adult ; Antioxidants ; Biomarkers ; Genetic Predisposition to Disease ; Genotype ; Humans ; Polymorphism, Genetic ; Superoxide Dismutase/genetics ; Superoxide Dismutase/metabolism |
| مستخلص: | Hypertension is the leading contributor to cardiovascular disease worldwide; the prevalence of hypertension is higher among black adults than other racial/ethnic groups. One of the cellular defense mechanisms against reactive oxygen species are the antioxidants, such as the enzyme superoxide dismutase (SOD). Therefore, this study aimed to analyze the influence of the SNP Val16Ala of the SOD2 gene on oxidative stress and hypertension in a community population of self-declared black individuals in southern Brazil. The 158 participants declared themselves black (black/brown) regarding their skin color, being 89 (56.3%) self-declared black and 69 (43.7%) brown. A real-time polymerase chain reaction determined the MnSOD Ala16Val polymorphism, and oxidative stress marker levels were significant, in addition to differences in the hypertensive group regarding the levels of carbonyl ( p = .016), thiobarbituric acid reactive substances ( p = .040), ischemia-modified albumin ( p = .046), total antioxidant capacity ( p = .011), and Nitric oxide metabolites ( p = .029). The SOD Val/Val genotype was considered a risk factor regardless of the other variables for hypertension ( p = .034). The Val16Ala polymorphism of the MnSOD gene presented an association with hypertension. |
| فهرسة مساهمة: | Keywords: Oxidative stress; SOD2; genetic polymorphism; hypertension |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Biomarkers) 0 (Serum Albumin) EC 1.15.1.1 (Superoxide Dismutase) |
| تواريخ الأحداث: | Date Created: 20220415 Date Completed: 20220530 Latest Revision: 20220531 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/10715762.2022.2060827 |
| PMID: | 35426339 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1029-2470 |
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| DOI: | 10.1080/10715762.2022.2060827 |