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Effects of Ethanolic Extract of Cynara cardunculus (Artichoke) Leaves on Neuroinflammatory and Neurochemical Parameters in a Diet-Induced Mice Obesity Model.

التفاصيل البيبلوغرافية
العنوان: Effects of Ethanolic Extract of Cynara cardunculus (Artichoke) Leaves on Neuroinflammatory and Neurochemical Parameters in a Diet-Induced Mice Obesity Model.
المؤلفون: Piccinini A; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Oliveira MP; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Silva MR; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Bett GS; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Becker IB; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Mendes TF; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Salla DH; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Silva LE; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Vilela TC; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Moraes FM; Pharmaceutical Technology Group, Postgraduate Program in Environmental Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Moterle D; Pharmaceutical Technology Group, Postgraduate Program in Environmental Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Damiani AP; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, University of Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Dagostin LS; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, University of Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Tietbohl LT; Laboratory of Experimental Phisiopatology, Postgraduate Program in Health Sciences, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Bittencourt JVS; Laboratory of Experimental Phisiopatology, Postgraduate Program in Health Sciences, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Biehl E; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Denicol TL; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Bonfante SR; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Andrade VM; Laboratory of Biomedicine Translational, Postgraduate Program in Health Sciences, University of Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Silveira PCL; Laboratory of Experimental Phisiopatology, Postgraduate Program in Health Sciences, Universidade Do Extremo Sul Catarinense, Criciúma, Santa Catarina, Brazil., Prophiro JS; Immunoparasitology Research Group, Postgraduate Program in Health Sciences and Postgraduate Program in Environmental Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Ferreira GK; Educacional Society of de Santa Catarina, Joinville, Santa Catarina, Brazil., Petronilho F; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Kanis LA; Pharmaceutical Technology Group, Postgraduate Program in Environmental Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Rezin GT; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil. gitezza@hotmail.com.
المصدر: Neurochemical research [Neurochem Res] 2022 Jul; Vol. 47 (7), pp. 1888-1903. Date of Electronic Publication: 2022 Apr 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 7613461 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6903 (Electronic) Linking ISSN: 03643190 NLM ISO Abbreviation: Neurochem Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers
Original Publication: New York, Plenum Press
مواضيع طبية MeSH: Cynara*/chemistry , Cynara scolymus*/chemistry, Animals ; Antioxidants/pharmacology ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Ethanol/adverse effects ; Male ; Mice ; Obesity/drug therapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Leaves/chemistry
مستخلص: This study aimed to evaluate the effect of Cynara cardunculus leaf ethanol extract on inflammatory and oxidative stress parameters in the hypothalamus, prefrontal cortex, hippocampus, striatum, cerebral cortex and liver of high-fat diet-induced obese mice. Food intake, body weight, visceral fat weight, and liver weight were also evaluated. Male Swiss mice were divided into control (low-fat purified diet) and obese (high-fat purified diet) groups. After 6 weeks, mice were divided into control + saline, control + C. cardunculus leaf ethanol extract, obese + saline, obese + C. cardunculus leaf ethanol extract. Cynara cardunculus leaf ethanol extract (1600 mg/kg/day) or saline was administered orally for 4 weeks. Brain structures (hypothalamus, hippocampus, prefrontal cortex, striatum and cerebral cortex) and liver were removed. Treatment with C. cardunculus leaf ethanol extract did not affect body weight but did reduce visceral fat. Obesity can cause inflammation and oxidative stress and increase the activity of antioxidant enzymes in brain structures. Treatment with ethanolic extract of C. cardunculus leaves partially reversed the changes in inflammatory damage parameters and oxidative damage parameters and attenuated changes in the antioxidant defense. The C. cardunculus leaf ethanol extract benefited from the brains of obese animals by partially reversing the changes caused by the consumption of a high-fat diet and the consequent obesity. These results corroborate those of studies indicating that the C. cardunculus leaf ethanol extract can contribute to the treatment of obesity.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Cynara cardunculus; Inflammation; Obesity; Oxidative stress
المشرفين على المادة: 0 (Antioxidants)
0 (Plant Extracts)
3K9958V90M (Ethanol)
تواريخ الأحداث: Date Created: 20220415 Date Completed: 20220624 Latest Revision: 20220624
رمز التحديث: 20240628
DOI: 10.1007/s11064-022-03572-6
PMID: 35426598
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-6903
DOI:10.1007/s11064-022-03572-6