دورية أكاديمية
Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease.
| العنوان: | Airway Aging and Methylation Disruptions in HIV-associated Chronic Obstructive Pulmonary Disease. |
|---|---|
| المؤلفون: | Hernández Cordero AI; Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada., Yang CX; Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada., Yang J; Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada., Horvath S; Department of Biostatistics, Fielding School of Public Health, University of California Los Angeles, Los Angeles, California.; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California., Shaipanich T; Division of Respiratory Medicine, Department of Medicine., MacIsaac J; Centre for Molecular Medicine and Therapeutics., Lin DTS; Centre for Molecular Medicine and Therapeutics., Kobor MS; Centre for Molecular Medicine and Therapeutics., Guillemi S; Faculty of Medicine, and.; British Columbia Centre for Excellence in HIV/AIDS, Providence Health Care, Vancouver, British Columbia, Canada., Harris M; Faculty of Medicine, and.; British Columbia Centre for Excellence in HIV/AIDS, Providence Health Care, Vancouver, British Columbia, Canada., Lam W; British Columbia Cancer, University of British Columbia, Vancouver, British Columbia, Canada; and., Lam S; Faculty of Medicine, and., Montaner J; Faculty of Medicine, and.; British Columbia Centre for Excellence in HIV/AIDS, Providence Health Care, Vancouver, British Columbia, Canada., Man SFP; Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.; Division of Respiratory Medicine, Department of Medicine., Sin DD; Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.; Division of Respiratory Medicine, Department of Medicine., Leung JM; Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.; Division of Respiratory Medicine, Department of Medicine. |
| المصدر: | American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2022 Jul 15; Vol. 206 (2), pp. 150-160. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Thoracic Society Country of Publication: United States NLM ID: 9421642 Publication Model: Print Cited Medium: Internet ISSN: 1535-4970 (Electronic) Linking ISSN: 1073449X NLM ISO Abbreviation: Am J Respir Crit Care Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : New York, NY : American Thoracic Society Original Publication: New York, NY : American Lung Association, c1994- |
| مواضيع طبية MeSH: | HIV Infections*/complications , HIV Infections*/genetics , Pulmonary Disease, Chronic Obstructive*/complications , Pulmonary Disease, Chronic Obstructive*/epidemiology , Pulmonary Disease, Chronic Obstructive*/genetics, Adult ; Aging/genetics ; DNA Methylation/genetics ; Epigenomics ; Humans |
| مستخلص: | Rationale: Age-related diseases like chronic obstructive pulmonary disease (COPD) occur at higher rates in people living with human immunodeficiency virus (PLWH) than in uninfected populations. Objectives: To identify whether accelerated aging can be observed in the airways of PLWH with COPD, manifest by a unique DNA methylation signature. Methods: Bronchial epithelial brushings from PLWH with and without COPD and HIV-uninfected adults with and without COPD ( N = 76) were profiled for DNA methylation and gene expression. We evaluated global Alu and LINE-1 methylation and calculated the epigenetic age using the Horvath clock and the methylation telomere length estimator. To identify genome-wide differential DNA methylation and gene expression associated with HIV and COPD, robust linear models were used followed by an expression quantitative trait methylation (eQTM) analysis. Measurements and Main Results: Epigenetic age acceleration and shorter methylation estimates of telomere length were found in PLWH with COPD compared with PLWH without COPD and uninfected patients with and without COPD. Global hypomethylation was identified in PLWH. We identified 7,970 cytosine bases located next to a guanine base (CpG sites), 293 genes, and 9 expression quantitative trait methylation-gene pairs associated with the interaction between HIV and COPD. Actin binding LIM protein family member 3 ( ABLIM3 ) was one of the novel candidate genes for HIV-associated COPD highlighted by our analysis. Conclusions: Methylation age acceleration is observed in the airway epithelium of PLWH with COPD, a process that may be responsible for the heightened risk of COPD in this population. Their distinct methylation profile, differing from that observed in patients with COPD alone, suggests a unique pathogenesis to HIV-associated COPD. The associations warrant further investigation to establish causality. |
| التعليقات: | Comment in: Am J Respir Crit Care Med. 2022 Jul 15;206(2):131-132. (PMID: 35579631) |
| References: | J Infect Dis. 2021 May 28;223(10):1681-1689. (PMID: 32959881) Genet Mol Res. 2013 Oct 07;12(4):4162-70. (PMID: 24114211) Biostatistics. 2007 Jan;8(1):118-27. (PMID: 16632515) Lung Cancer. 2015 Nov;90(2):121-7. (PMID: 26363803) Am J Prev Med. 2014 Mar;46(3 Suppl 1):S7-15. (PMID: 24512933) Saudi J Biol Sci. 2018 Sep;25(6):1220-1226. (PMID: 30174526) Epigenetics. 2019 Feb;14(2):171-184. (PMID: 30764717) Clin Epigenetics. 2018 Dec 10;10(1):152. (PMID: 30526669) Mech Ageing Dev. 2007 Jan;128(1):92-105. (PMID: 17116321) Clin Epigenetics. 2020 Jun 25;12(1):93. (PMID: 32586373) Philos Trans R Soc Lond B Biol Sci. 2018 Mar 5;373(1741):. (PMID: 29335375) BMJ Open. 2012 Oct 17;2(5):. (PMID: 23075571) Infection. 2013 Apr;41(2):347-53. (PMID: 22971938) Nucleic Acids Res. 2004 Feb 18;32(3):e38. (PMID: 14973332) Bioinformatics. 2013 Jan 15;29(2):189-96. (PMID: 23175756) Aging Pathobiol Ther. 2021 Mar 29;3(1):12-13. (PMID: 35083452) Epigenetics Chromatin. 2015 Jan 27;8:6. (PMID: 25972926) OMICS. 2012 May;16(5):284-7. (PMID: 22455463) F1000Res. 2019 Jul 2;8:. (PMID: 31316753) Mol Cell. 2013 Jan 24;49(2):359-367. (PMID: 23177740) Am J Respir Crit Care Med. 2013 May 1;187(9):933-42. (PMID: 23471465) Eur Respir J. 2005 Aug;26(2):319-38. (PMID: 16055882) Cell. 2016 Nov 17;167(5):1415-1429.e19. (PMID: 27863252) Am J Respir Crit Care Med. 2011 Feb 1;183(3):388-95. (PMID: 20851926) Respir Res. 2018 Jul 27;19(1):140. (PMID: 30053882) Thorax. 2021 May;76(5):448-455. (PMID: 33443234) Aging Cell. 2019 Dec;18(6):e13028. (PMID: 31496122) Cell. 2017 Mar 9;168(6):960-976. (PMID: 28283069) Nucleic Acids Res. 2013 Apr;41(7):e90. (PMID: 23476028) Nat Genet. 2001 Jun;28(2):139-45. (PMID: 11381260) Proc Am Thorac Soc. 2011 Jun;8(3):320-5. (PMID: 21653535) Aging (Albany NY). 2017 Feb 23;9(3):687-705. (PMID: 28237978) Biochim Biophys Acta. 2007 Jan;1775(1):138-62. (PMID: 17045745) Cell. 2020 Sep 3;182(5):1214-1231.e11. (PMID: 32888494) Nat Genet. 2017 Mar;49(3):416-425. (PMID: 28166213) Lancet Respir Med. 2014 Jul;2(7):583-92. (PMID: 24831854) Nucleic Acids Res. 2017 Sep 6;45(15):8697-8711. (PMID: 28911103) Aging (Albany NY). 2019 Aug 18;11(16):5895-5923. (PMID: 31422385) Mol Biol Rep. 2022 Jan;49(1):463-476. (PMID: 34739690) Nat Methods. 2017 Apr;14(4):417-419. (PMID: 28263959) Aging (Albany NY). 2018 Jul 26;10(7):1758-1775. (PMID: 30048243) Genome Biol. 2013;14(10):R115. (PMID: 24138928) Respir Res. 2018 Jun 13;19(1):117. (PMID: 29895291) Epigenomics. 2017 Jul;9(7):971-984. (PMID: 28621160) Immunity. 2009 May;30(5):696-707. (PMID: 19409814) |
| معلومات مُعتمدة: | Canada CIHR |
| فهرسة مساهمة: | Keywords: COPD; HIV; airway epithelium; epigenomics; gene expression |
| تواريخ الأحداث: | Date Created: 20220415 Date Completed: 20220719 Latest Revision: 20230202 |
| رمز التحديث: | 20230202 |
| مُعرف محوري في PubMed: | PMC9887412 |
| DOI: | 10.1164/rccm.202106-1440OC |
| PMID: | 35426765 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1535-4970 |
|---|---|
| DOI: | 10.1164/rccm.202106-1440OC |