دورية أكاديمية
Acrylonitrile exposure triggers ovarian inflammation and decreases oocyte quality probably via mitochondrial dysfunction induced apoptosis in mice.
| العنوان: | Acrylonitrile exposure triggers ovarian inflammation and decreases oocyte quality probably via mitochondrial dysfunction induced apoptosis in mice. |
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| المؤلفون: | Luo YS; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., He QK; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., Sun MX; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., Qiao FX; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., Liu YC; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., Xu CL; Reproductive Medical Center of Nanning Second People's Hospital, Nanning, Guangxi, 530031, China., Xu ZR; Translational Medicine Research Center, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi, 530011, China., Zhao SC; Medical College, Guangxi University, Nanning, Guangxi, 530004, China., Wang HL; Department of Basic Medicine, School of Medicine, Xiamen University, Xiamen City, Fujian Province, 361102, China., Qi ZQ; Medical College, Guangxi University, Nanning, Guangxi, 530004, China. Electronic address: yxyyz@gxu.edu.cn., Liu Y; Medical College, Guangxi University, Nanning, Guangxi, 530004, China. Electronic address: liuyu@gxu.edu.cn. |
| المصدر: | Chemico-biological interactions [Chem Biol Interact] 2022 Jun 01; Vol. 360, pp. 109934. Date of Electronic Publication: 2022 Apr 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | Acrylonitrile*/metabolism , Acrylonitrile*/toxicity, Animals ; Apoptosis ; Female ; Inflammation/metabolism ; Mammals ; Mice ; Mitochondria/metabolism ; Oocytes |
| مستخلص: | Acrylonitrile is an organic chemical synthetic monomer that is widely used in food packaging and manufacturing. Animal studies have reported that acrylonitrile is carcinogenic and toxic, but the effects on the female reproductive function in mammals are unknown. In the present study, we report that acrylonitrile treatment affects ovarian homeostasis in mice, resulting in impaired follicular development. Follicles in acrylonitrile-exposed mice exhibited high levels of inflammation and apoptosis, and acrylonitrile treatment interfered with oocyte development. Transcriptomics analysis showed that acrylonitrile altered the expression of oocyte genes related to apoptosis, oxidative stress, endoplasmic reticulum stress, and autophagy. Further molecular tests revealed that acrylonitrile induced early apoptosis, DNA damage, elevated levels of reactive oxygen species, endoplasmic reticulum abnormalities, and lysosomal aggregation. We also observed disruption of mitochondrial structure and distribution and depolarization of membrane potential. Finally, acrylonitrile treatment in female mice decreased the number and weight of offspring. Altogether, these findings suggest that acrylonitrile impairs the stability of the ovarian internal environment, which in turn affects oocyte development and reduces the number of offspring. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Acrylonitrile; Apoptosis; Endoplasmic reticulum stress; Oocyte; Ovary |
| المشرفين على المادة: | MP1U0D42PE (Acrylonitrile) |
| تواريخ الأحداث: | Date Created: 20220416 Date Completed: 20220510 Latest Revision: 20220510 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.cbi.2022.109934 |
| PMID: | 35429547 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7786 |
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| DOI: | 10.1016/j.cbi.2022.109934 |