دورية أكاديمية
أعرض في EDS

Does a Bleeding Disorder Lessen the Efficacy of the 52-mg Levonorgestrel-Releasing Intrauterine System for Heavy Menstrual Bleeding in Adolescents? A Retrospective Multicenter Study.

التفاصيل البيبلوغرافية
العنوان: Does a Bleeding Disorder Lessen the Efficacy of the 52-mg Levonorgestrel-Releasing Intrauterine System for Heavy Menstrual Bleeding in Adolescents? A Retrospective Multicenter Study.
المؤلفون: Khalighi M; Division of Adolescent and Young Adult Medicine, Children's Hospital Los Angeles, Los Angeles, California. Electronic address: mkhalig88@gmail.com., Wheeler AP; Department of Pathology, Microbiology, & Immunology, Vanderbilt University Medical Center, Nashville, Tennessee., Adeyemi-Fowode OA; Department of Pediatric and Adolescent Gynecology, Texas Children's Hospital, Houston, Texas., Kouides PA; Department of Hematology and Medical Oncology, Rochester General Hospital, University of Rochester School of Medicine and Mary M. Gooley Hemophilia Treatment Center, Rochester, New York., Durazo-Arvizu RA; The Saban Research Institute Biostatistics Core, Children's Hospital Los Angeles, Los Angeles, California., Haley K; Division of Hematology and Oncology, Oregon Health & Sciences University, Portland, Oregon., Dersch CM; Department of Obstetrics and Gynecology, Maine Medical Center, Portland, Maine., Weyand AC; Division of Hematology and Oncology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan., Baldwin MK; Department of Obstetrics and Gynecology, Oregon Health & Sciences University, Portland, Oregon., Borzutzky C; Division of Adolescent and Young Adult Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California.
المصدر: The Journal of adolescent health : official publication of the Society for Adolescent Medicine [J Adolesc Health] 2022 Aug; Vol. 71 (2), pp. 204-209. Date of Electronic Publication: 2022 Apr 13.
نوع المنشور: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9102136 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1972 (Electronic) Linking ISSN: 1054139X NLM ISO Abbreviation: J Adolesc Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Elsevier, c1991-
مواضيع طبية MeSH: Contraceptive Agents, Female* , Intrauterine Devices, Medicated* , Menorrhagia*/drug therapy, Adolescent ; Adult ; Female ; Humans ; Levonorgestrel/therapeutic use ; Retrospective Studies ; Young Adult
مستخلص: Purpose: The aim of this study is to compare the patient-reported bleeding outcomes and complication rates with the use of the 52-mg levonorgestrel-releasing intrauterine system (52-LNG-IUS) for treatment of heavy menstrual bleeding (HMB) among adolescents with and without a diagnosed inherited bleeding disorder (BD) within the first 12 months after insertion.
Methods: Retrospective chart review was conducted of adolescents ages 14-21 years, with and without an inherited BD, who underwent 52-LNG-IUS insertion between September 2013 and February 2020 for the treatment of HMB.
Results: One hundred forty-four 52-LNG-IUS insertions among 139 subjects were evaluated. Fifty-nine (41%) of these were among adolescents with a diagnosed inherited BD, and 85 (59%) were among those without a BD. Among subjects with follow-up, documentation of patient-reported bleeding outcome, and a retained IUS (92/144), both groups subjectively reported improvement in bleeding outcome, with 91.7% (33/36) of those with a BD and 94.6% (53/56) of those without a BD reporting that bleeding outcome was better than prior to IUS insertion (p = .675). There was no statistically significant difference in the rate of spontaneous expulsion (p = .233), with the rate of expulsion in the first 12 months after placement among those with a BD of 13.7% (7/51) and 6.8% for those without a BD (5/72).
Discussion: Adolescents with HMB both with and without an inherited BD benefit from the 52-LNG-IUS for the treatment of HMB. Rates of spontaneous IUS expulsion are not statistically different regardless of the presence of a BD and are similar to rates found in other studies of intrauterine device use in adolescents.
(Copyright © 2022 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: K12 HD085809 United States HD NICHD NIH HHS; UL1 TR001855 United States TR NCATS NIH HHS
فهرسة مساهمة: Keywords: Adolescent; Heavy menstrual bleeding; Hemorrhagic disorders; Intrauterine devices
المشرفين على المادة: 0 (Contraceptive Agents, Female)
5W7SIA7YZW (Levonorgestrel)
تواريخ الأحداث: Date Created: 20220417 Date Completed: 20220726 Latest Revision: 20240502
رمز التحديث: 20240502
مُعرف محوري في PubMed: PMC9329177
DOI: 10.1016/j.jadohealth.2022.02.018
PMID: 35430143
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1972
DOI:10.1016/j.jadohealth.2022.02.018