دورية أكاديمية
أعرض في EDS

Mass Spectrometry-Based Proteomics for Biomarker Discovery.

التفاصيل البيبلوغرافية
العنوان: Mass Spectrometry-Based Proteomics for Biomarker Discovery.
المؤلفون: Cao Z; Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA., Yu LR; Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. Lirong.yu@fda.hhs.gov.
المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2022; Vol. 2486, pp. 3-17.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, P.H.S.
اللغة: English
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: Totowa, NJ : Humana Press
Original Publication: Clifton, N.J. : Humana Press,
مواضيع طبية MeSH: Proteomics*/methods , Tandem Mass Spectrometry*/methods, Biomarkers ; Chromatography, Liquid/methods ; Proteome/analysis
مستخلص: Proteomics plays a pivotal role in systems medicine, in which pharmacoproteomics and toxicoproteomics have been developed to address questions related to efficacy and toxicity of drugs. Mass spectrometry is the core technology for quantitative proteomics, providing the capabilities of identification and quantitation of thousands of proteins. The technology has been applied to biomarker discovery and understanding the mechanisms of drug action. Both stable isotope labeling of proteins or peptides and label-free approaches have been incorporated with multidimensional LC separation and tandem mass spectrometry (LC-MS/MS) to increase the coverage and depth of proteome analysis. A protocol of such an approach exemplified by dimethyl labeling in combination with 2D-LC-MS/MS is described. With further development of novel proteomic tools and increase in sample throughput, the full spectrum of mass spectrometry-based proteomic research will greatly advance systems medicine.
(© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
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فهرسة مساهمة: Keywords: Biomarker; Liquid chromatography; Mass spectrometry; Protein quantitation; Proteomics; Stable isotope labeling; Tandem MS
المشرفين على المادة: 0 (Biomarkers)
0 (Proteome)
تواريخ الأحداث: Date Created: 20220419 Date Completed: 20220420 Latest Revision: 20220719
رمز التحديث: 20231215
DOI: 10.1007/978-1-0716-2265-0_1
PMID: 35437715
قاعدة البيانات: MEDLINE
الوصف
تدمد:1940-6029
DOI:10.1007/978-1-0716-2265-0_1