دورية أكاديمية
أعرض في EDS

Immune cell subsets in interface cutaneous immune-related adverse events associated with anti-PD-1 therapy resemble acute graft versus host disease more than lichen planus.

التفاصيل البيبلوغرافية
العنوان: Immune cell subsets in interface cutaneous immune-related adverse events associated with anti-PD-1 therapy resemble acute graft versus host disease more than lichen planus.
المؤلفون: Almodovar Cruz GE; Department of Dermatology at Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center and Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA., Kaunitz G; Department of Dermatology at Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center and Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA., Stein JE; Department of Pathology at Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center and Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA., Sander I; Department of Dermatology at Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center and Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA., Hollmann T; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA., Cottrell TR; Department of Pathology at Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center and Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA., Taube JM; Department of Dermatology at Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center and Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA.; Department of Pathology at Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center and Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA.; Department of Oncology at Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center and Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA., Sunshine JC; Department of Dermatology at Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center and Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA.; Department of Pathology at Johns Hopkins University School of Medicine, Sidney Kimmel Comprehensive Cancer Center and Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore, Maryland, USA.
المصدر: Journal of cutaneous pathology [J Cutan Pathol] 2022 Aug; Vol. 49 (8), pp. 701-708. Date of Electronic Publication: 2022 May 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0425124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0560 (Electronic) Linking ISSN: 03036987 NLM ISO Abbreviation: J Cutan Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: Malden, MA : Wiley
Original Publication: Copenhagen, Blackwell Munksgaard.
مواضيع طبية MeSH: Graft vs Host Disease* , Lichen Planus*/pathology, Humans ; Immunohistochemistry ; Skin/pathology ; T-Lymphocytes/pathology
مستخلص: Background: Checkpoint immunotherapy is frequently associated with cutaneous immune-related adverse events (cirAEs), and among those, the most common subtype shows interface reaction patterns that have been likened to lichen planus (LP); however, cutaneous acute graft versus host disease (aGVHD) may be a closer histopathologic comparator. We used quantitative pathology to compare the immunologic composition of anti-PD-1-associated interface reactions to LP and aGVHD to assess for similarities and differences between these cutaneous eruptions.
Methods: Immunohistochemistry for CD4, CD8, CD68, PD-1, and PD-L1 was performed on formalin-fixed paraffin-embedded tissue from patients with anti-PD-1 interface cirAEs (n = 4), LP (n = 9), or aGVHD (n = 5). Densities of immune cell subsets expressing each marker were quantified using the HALO image analysis immune cell module. Plasma cell and eosinophil density were quantified on routine H&E slides.
Results: Specimens from patients with anti-PD-1 interface cirAEs showed equivalent total cell densities and immune cell composition to those with aGVHD. Patients with LP showed higher total immune cell infiltration, higher absolute T-cell densities, increased CD8 proportion, and reduced histiocytic component. The cases with the highest plasma cell counts were all anti-PD-1 interface cirAEs and aGVHD.
Conclusion: The composition of immune cell subsets in anti-PD-1 interface cirAEs more closely resembles the immune response seen in aGVHD than LP within our cohort. This warrants a closer look via advanced analytics and may have implications for shared pathogenesis and potential treatment options.
(© 2022 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: P30 CA006973 United States CA NCI NIH HHS; Moving for Melanoma of Delaware; T32 CA193145 United States CA NCI NIH HHS; P30 CA008748 United States CA NCI NIH HHS; Mark Foundation For Cancer Research; Bloomberg~Kimmel Institute for Cancer Immunotherapy; T32 CA193145 United States NH NIH HHS; R01 CA142779 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: cutaneous eruptions; graft versus host disease; immune-related adverse events; immunologic markers; lichen planus
تواريخ الأحداث: Date Created: 20220421 Date Completed: 20220720 Latest Revision: 20221015
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC9305991
DOI: 10.1111/cup.14242
PMID: 35445765
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-0560
DOI:10.1111/cup.14242