دورية أكاديمية
أعرض في EDS

Antimicrobial resistance and genetic background of non-typhoidal Salmonella enterica strains isolated from human infections in São Paulo, Brazil (2000-2019).

التفاصيل البيبلوغرافية
العنوان: Antimicrobial resistance and genetic background of non-typhoidal Salmonella enterica strains isolated from human infections in São Paulo, Brazil (2000-2019).
المؤلفون: Calarga AP; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), 255 Monteiro Lobato St, Campinas, São Paulo, 13083-650, Brazil. parolin.aline@gmail.com., Gontijo MTP; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), 255 Monteiro Lobato St, Campinas, São Paulo, 13083-650, Brazil., de Almeida LGP; National Laboratory of Scientific Computing (LNCC), Petropólis, Rio de Janeiro, 25651-075, Brazil., de Vasconcelos ATR; National Laboratory of Scientific Computing (LNCC), Petropólis, Rio de Janeiro, 25651-075, Brazil., Nascimento LC; Central Laboratory for High Performance Technologies (LaCTAD), University of Campinas (UNICAMP), Campinas, São Paulo, 13083-886, Brazil., de Moraes Barbosa TMC; Adolfo Lutz Institute, Regional Laboratory Center Campinas III, Campinas, São Paulo, 13035-420, Brazil., de Carvalho Perri TM; Adolfo Lutz Institute, Regional Laboratory Center Campinas III, Campinas, São Paulo, 13035-420, Brazil., Dos Santos SR; Division of Clinical Laboratory of the University Hospital of São Paulo, University of São Paulo (USP), São Paulo, São Paulo, 05508-000, Brazil., Tiba-Casas MR; Adolfo Lutz Institute, Central Laboratory, São Paulo, São Paulo, 01246-000, Brazil., Marques EGL; Adolfo Lutz Institute, Regional Laboratory Center Campinas III, Campinas, São Paulo, 13035-420, Brazil., Ferreira CM; Adolfo Lutz Institute, Regional Laboratory Center Campinas III, Campinas, São Paulo, 13035-420, Brazil., Brocchi M; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas (UNICAMP), 255 Monteiro Lobato St, Campinas, São Paulo, 13083-650, Brazil. mbrocchi@unicamp.br.
المصدر: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2022 Sep; Vol. 53 (3), pp. 1249-1262. Date of Electronic Publication: 2022 Apr 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Brazil NLM ID: 101095924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4405 (Electronic) Linking ISSN: 15178382 NLM ISO Abbreviation: Braz J Microbiol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2019- : Switzerland, AG : Springer International Publishing
Original Publication: Rio de Janeiro, RJ, Brasil : Sociedade Brasileira de Microbiologia
مواضيع طبية MeSH: Drug Resistance, Bacterial*/genetics , Salmonella Infections*/microbiology , Salmonella enterica*/genetics, Anti-Bacterial Agents/pharmacology ; Brazil ; Colistin/pharmacology ; Drug Resistance, Multiple, Bacterial/genetics ; Genetic Background ; Humans ; Microbial Sensitivity Tests
مستخلص: Salmonella enterica causes Salmonellosis, an important infection in humans and other animals. The number of multidrug-resistant (MDR) phenotypes associated with Salmonella spp. isolates is increasing worldwide, causing public health concern. Here, we aim to characterize the antimicrobial-resistant phenotype of 789 non-typhoidal S. enterica strains isolated from human infections in the state of São Paulo, Brazil, along 20 years (2000-2019). Among the non-susceptible isolates, 31.55, 14.06, and 13.18% were resistant to aminoglycosides, tetracycline, and β-lactams, respectively. Moreover, 68 and 11 isolates were considered MDR and Extended Spectrum β-Lactamase (ESBL) producers, respectively, whereas one isolate was colistin-resistant. We selected four strains to obtain a draft of the Genome Sequence; one S. Infantis (ST32), one S. Enteritidis (ST11), one S. I 4,[5],12:i:- (ST19), and one S. Typhimurium (ST313). Among them, three presented at least one of the following antimicrobial resistance genes (AMR) linked to mobile DNA: bla TEM-1B , dfrA1, tetA, sul1, floR, aac(6')-laa, and qnrE1. This is the first description of the plasmid-mediated quinolone resistance (PMQR) gene qnrE1 in a clinical isolate of S. I 4,[5],12:i:-. The S. Typhimurium is a colistin-resistant isolate, but did not harbor mcr genes, but it presented mutations within the mgrB, pmrB, and pmrC regions that might be linked to the colistin-resistant phenotype. The virulence pattern of the four isolates resembled the virulence pattern of the highly pathogenic S. Typhimurium UK-1 reference strain in assays involving the in vivo Galleria mellonella model. In conclusion, most isolates studied here are susceptible, but a small percentage present an MDR or ESBL-producer and pathogenic phenotype. Sequence analyses revealed plasmid-encoded AMR genes, such as β-lactam and fluoroquinolone resistance genes, indicating that these characteristics can be potentially disseminated among other bacterial strains.
(© 2022. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.)
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معلومات مُعتمدة: 2014/13412-8 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2017/10051-2 Fundação de Amparo à Pesquisa do Estado de São Paulo; 309380/2019-7 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 309800/2015-3 Conselho Nacional de Desenvolvimento Científico e Tecnológico
فهرسة مساهمة: Keywords: Antimicrobial resistance; Brazilian ST313; Fluoroquinolones; Genetic virulence; Salmonella enterica; β-lactams
المشرفين على المادة: 0 (Anti-Bacterial Agents)
Z67X93HJG1 (Colistin)
تواريخ الأحداث: Date Created: 20220421 Date Completed: 20220908 Latest Revision: 20230422
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9433476
DOI: 10.1007/s42770-022-00748-8
PMID: 35446010
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-4405
DOI:10.1007/s42770-022-00748-8