دورية أكاديمية
أعرض في EDS

Population-based incidence of intraocular tumours in Olmsted County, Minnesota.

التفاصيل البيبلوغرافية
العنوان: Population-based incidence of intraocular tumours in Olmsted County, Minnesota.
المؤلفون: Oyemade KA; Mayo Clinic, Alix School of Medicine, Rochester, Minnesota, USA., Xu TT; Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA., Lopez Dominguez J; Mayo Clinic, Alix School of Medicine, Jacksonville, Florida, USA., Dumbrava MG; Mayo Clinic, Alix School of Medicine, Rochester, Minnesota, USA., Hodge DO; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida, USA., White LJ; Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida, USA., Dalvin LA; Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA dalvin.lauren@mayo.edu.
المصدر: The British journal of ophthalmology [Br J Ophthalmol] 2023 Sep; Vol. 107 (9), pp. 1369-1376. Date of Electronic Publication: 2022 Apr 21.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 0421041 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2079 (Electronic) Linking ISSN: 00071161 NLM ISO Abbreviation: Br J Ophthalmol Subsets: MEDLINE
أسماء مطبوعة: Publication: Jan. 1992- : London : BMJ Pub. Group
Original Publication: 1917-Dec. 1991: London : British Medical Association
مواضيع طبية MeSH: Melanoma*/epidemiology , Melanoma*/pathology , Nevus, Pigmented* , Choroid Neoplasms*/epidemiology , Iris Neoplasms* , Skin Neoplasms*, Humans ; Incidence ; Retrospective Studies ; Minnesota/epidemiology
مستخلص: Background/aims: To determine population-based incidence of intraocular tumours in Olmsted County, Minnesota.
Methods: Record review of the Rochester Epidemiology Project medical record linkage system from 1 January 2006 to 31 December 2015 for patient demographics, tumour type by clinical diagnosis and presence or absence of confirmation by histopathology. The incidence rate of any intraocular tumour and of each tumour type was calculated per million person-years. Poisson regression analysis was used to analyse changes in incidence over time.
Results: There were 948 patients diagnosed with intraocular tumours resulting in an age-adjusted and sex-adjusted incidence rate of 727.5 per million (95% CI: 680.8 to 774.2, p<0.05). Most tumours were benign (953, 98%). Of the benign lesions, melanocytic lesions were the majority (942, 97%), with adjusted incidence rates of 646.9 (95% CI: 602.8 to 691.1) for choroidal nevus and 55.8 (95% CI: 43.2 to 64.8) for iris nevus. Malignant lesions were rare (16, 2%) with 13 cases of choroidal melanoma and 1 case each of iris melanoma, retinal leukaemic infiltration and metastasis. The adjusted incidence rate for choroidal melanoma was 7.1 (95% CI: 2.5 to 11.8).
Conclusion: In a population-based setting, most intraocular tumours are benign and melanocytic. Although malignant lesions are less common, it is important to remain vigilant with appropriate monitoring given the potential for vision loss and life-threatening malignancy.
Competing Interests: Competing interests: None declared.
(© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
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معلومات مُعتمدة: R33 AG058738 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Epidemiology
SCR Disease Name: Uveal melanoma
تواريخ الأحداث: Date Created: 20220422 Date Completed: 20230823 Latest Revision: 20231003
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10350913
DOI: 10.1136/bjophthalmol-2021-320682
PMID: 35450938
قاعدة البيانات: MEDLINE
الوصف
تدمد:1468-2079
DOI:10.1136/bjophthalmol-2021-320682