دورية أكاديمية
أعرض في EDS

Effect of Diabetes Mellitus on Implant Osseointegration of Titanium Screws: An Animal Experimental Study.

التفاصيل البيبلوغرافية
العنوان: Effect of Diabetes Mellitus on Implant Osseointegration of Titanium Screws: An Animal Experimental Study.
المؤلفون: Xiao L; Emergency Department, The First Affiliated Hospital, Jinan University, Guangzhou, China.; Department of Orthopaedic Surgery and Sports Medicine Center, The First Affiliated Hospital, Jinan University, Guangzhou, China., Zhou YJ; Emergency Department, The First Affiliated Hospital, Jinan University, Guangzhou, China., Jiang YB; Emergency Department, The First Affiliated Hospital, Jinan University, Guangzhou, China., Tam MS; IAN WO Medical Center, Macau, China., Cheang LH; Macau Medical Science and Technology Research Association, Macau, China., Wang HJ; Department of Orthopaedic Surgery and Sports Medicine Center, The First Affiliated Hospital, Jinan University, Guangzhou, China., Zha ZG; Department of Orthopaedic Surgery and Sports Medicine Center, The First Affiliated Hospital, Jinan University, Guangzhou, China., Zheng XF; Department of Orthopaedic Surgery and Sports Medicine Center, The First Affiliated Hospital, Jinan University, Guangzhou, China.
المصدر: Orthopaedic surgery [Orthop Surg] 2022 Jun; Vol. 14 (6), pp. 1217-1228. Date of Electronic Publication: 2022 Apr 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley on behalf of the Chinese Orthopedic Association Country of Publication: Australia NLM ID: 101501666 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-7861 (Electronic) Linking ISSN: 17577853 NLM ISO Abbreviation: Orthop Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: 2013- : Richmond, Vic. Wiley on behalf of the Chinese Orthopedic Association
Original Publication: Richmond, Vic. : Tianjin : Blackwell Pub. Asia ; Tianjin Hospital, 2009-
مواضيع طبية MeSH: Diabetes Mellitus* , Osseointegration*, Animals ; Bone Screws ; Humans ; RNA, Messenger ; Rats ; Titanium/chemistry ; Vascular Endothelial Growth Factor A
مستخلص: Objective: To explore the effect of diabetes mellitus (DM) on implant osseointegration of titanium screws.
Methods: Sixty rats were randomly divided into a DM group and a control group (each group, n = 30). DM group rats were injected with 1% Streptozotocin solution at 65 mg/kg to establish a DM model. Titanium screws were implanted into the rats' distal femurs in both groups. The rats were sacrificed for micro-CT scanning, micro-indentation, biomechanical detection, confocal Raman microspectroscopy, and histological and histomorphometric analysis at 4, 8, and 12 weeks post-implantation, respectively. Messenger RNA (mRNA) expression and protein expression of the related growth factors around the implant were analyzed using real-time polymerase chain reaction and Western blots.
Results: At 4, 8 and 12 weeks, micro-CT scanning, hematoxylin-eosin (HE) staining, Gieson's acid-magenta staining, and fluorescent labeled staining showed disorder in the bone tissue arrangement, a lack of new bone tissue, poor maturity and continuity, and poor trabecular bone parameters around the implant in the DM group. At 4, 8, and 12 weeks, the interfacial bone binding rate in the DM group was significantly lower (16.2% ± 4.8%, 25.7% ± 5.7%, 42.5% ± 5.8%, respectively) than that in the control group (23.6% ± 5.2%, 40.8% ± 6.3%, 64.2% ± 7.3%, respectively; P < 0.05). At 8 and 12 weeks, the elastic modulus (17.0 ± 1.8 and 15.1 ± 1.5 GPa, respectively) and trabecular bone hardness (571 ± 39 and 401 ± 37 MPa, respectively) in the DM group were significantly lower than the elastic modulus (23.4 ± 2.3 and 23.8 ± 1.8 GPa, respectively) and trabecular bone hardness (711 ± 45 and 719 ± 46 MPa, respectively) in the control group (P < 0.05). The maximum load required for the prosthesis pull-out experiment in the DM group at 4, 8, and 12 weeks (55.14 ± 6.74 N, 73.34 ± 8.43 N, and 83.45 ± 8.32 N, respectively) was significantly lower than that in the control group (77.45 ± 7.48 N, 93.28 ± 8.29 N, and 123.62 ± 9.43 N, respectively, P < 0.05). At 8 and 12 weeks, the mineral-to-collagen ratio in the DM group (6.56 % ± 1.35% and 4.45%± 1.25%, respectively) was significantly higher than that in the control group (5.31% ± 1.42% and 3.62% ± 1.33%, respectively, P < 0.05). At 12 weeks, mRNA and protein expression levels of bone morphogenetic protein 2, transforming growth factor-β1, vascular endothelial growth factor, osteopontin, osteocalcin, and runt-related transcription factor 2 in the DM group were significantly lower than that in the control group.
Conclusions: DM can negatively affect bone osseointegration, manifesting as disorder in bone tissue arrangement around the implant, a lack of new bone tissue, poor maturity and continuity, poor trabecular bone parameters and lower expression of the related growth factors.
(© 2022 The Authors. Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd.)
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معلومات مُعتمدة: 202102010079 Science and Technology Program of Guangzhou, China; 81601219 National Natural Science Foundation of China; 21620452 Fundamental Research Funds for the Central Universities
فهرسة مساهمة: Keywords: Biomechanics; Diabetes mellitus; Growth factors; Orthopedic implants; Osseointegration
المشرفين على المادة: 0 (RNA, Messenger)
0 (Vascular Endothelial Growth Factor A)
D1JT611TNE (Titanium)
تواريخ الأحداث: Date Created: 20220422 Date Completed: 20220606 Latest Revision: 20220716
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9163984
DOI: 10.1111/os.13274
PMID: 35451209
قاعدة البيانات: MEDLINE
الوصف
تدمد:1757-7861
DOI:10.1111/os.13274