دورية أكاديمية
"Dry oral and ocular manifestations and autoantibodies characteristic of primary Sjögren's syndrome in multiple sclerosis".
| العنوان: | "Dry oral and ocular manifestations and autoantibodies characteristic of primary Sjögren's syndrome in multiple sclerosis". |
|---|---|
| المؤلفون: | Hora JSI; Doctoral Student of the Postgraduate Program in Neurology (PPGNEURO), Federal University of the State of Rio de Janeiro - UNIRIO, Rio de Janeiro, RJ, Brazil. Electronic address: claudia.vasconcelos@unirio.br., da Silva MCR; Federal University of the State of Rio de Janeiro - UNIRIO, Rio de Janeiro, RJ, Brazil., Braga CLS; Coordinator of the Service of the Maxillofacial Surgery and Traumatology of the Ipanema Federal Hospital of the Ministry of Health, Rio de Janeiro, RJ, Brazil., Loureiro AM; Gaffrée and Guinle University Hospital, Federal University of the State of Rio de Janeiro - UNIRIO, Rio de Janeiro, RJ, Brazil., Alves ATNN; Coordinator of the Pathology Applied Biotechnology Laboratory (LABA), Fluminense Federal University (UFF), Niterói, RJ, Brazil., Lourenço SQC; Laboratory of Applied Biotechnology (LABA), Fluminense Federal University (UFF), Niterói, RJ, Brazil., Vasconcelos CCF; Federal University of the State of Rio de Janeiro UNIRIO, Medical Coordinator of the Neuroimmunology Outpatient Clinic at the Gaffree and Guinle University Hospital of Gaffree e Guinle University Hospital, Rio de Janeiro, RJ, Brazil. |
| المصدر: | Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2022 Jun; Vol. 62, pp. 103783. Date of Electronic Publication: 2022 Mar 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier B. V Country of Publication: Netherlands NLM ID: 101580247 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-0356 (Electronic) Linking ISSN: 22110348 NLM ISO Abbreviation: Mult Scler Relat Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Amsterdam] : Elsevier B. V. |
| مواضيع طبية MeSH: | Multiple Sclerosis*/complications , Sjogren's Syndrome*/complications , Sjogren's Syndrome*/diagnosis , Xerophthalmia*/complications , Xerophthalmia*/etiology , Xerostomia*/complications , Xerostomia*/etiology, Autoantibodies ; Humans |
| مستخلص: | Introduction: The relationship between primary Sjögren syndrome (pSS) and demyelinating diseases is still not well understood. These diseases seem to coexist amidst autoimmunity, raising questions about clinical characteristics, relationship with immunomodulatory treatment, and possible common immunological background underlying their pathogenesis. Objective: calculate the frequency of dry oral and ocular manifestations and autoantibodies characteristic of primary Sjögren's Syndrome in Multiple Sclerosis. Methods: 202 patients with multiple sclerosis answered a questionnaire to identify complaints of xerostomia and xerophthalmia, according to diagnostic criteria for primary Sjögren's syndrome; 43 answered positively to at least one question; 27 had comorbidities or used drugs that cause dry symptoms and were excluded; 16 patients were selected for examinations for oral, ocular and serum anti-Ro/SS-A autoantibody evaluation. Results: Eleven (68.75%) patients complained of xerostomia; 14 (87.5%) of xerophthalmia. Sialometry < 0.1 ml/min was observed in three (18.8%); 13 patients underwent minor salivary gland biopsy and histopathological examination: focal score > 1 in three (23.1%). Schirmer test was < 5 mm/5 min in four (25%). Lyssamine green/fluorescein dye score was > 5 in three (18.8%). Anti-Ro/SS-A > 10 UI/mm in two (12.5%). Three (1,49%) patients met current criteria for primary Sjögren's syndrome. Conclusions: Patients with MS may report xerostomia and/or xerophthalmia even in the absence of comorbidities and use of medications capable of causing these symptoms, which may fulfill the diagnostic criteria for pSS. In this study, the frequency of pSS according to current criteria was within the range observed in the literature with older criteria. But the question remains whether the association between these diseases is fortuitous or whether there is a pathogenic link. (Copyright © 2022. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: Autoantibodies; Keratoconjunctivitis sicca; Multiple sclerosis; Sjogren's syndrome; Xerophthalmia; Xerostomia |
| المشرفين على المادة: | 0 (Autoantibodies) |
| تواريخ الأحداث: | Date Created: 20220422 Date Completed: 20220614 Latest Revision: 20220614 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.msard.2022.103783 |
| PMID: | 35452962 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 2211-0356 |
|---|---|
| DOI: | 10.1016/j.msard.2022.103783 |