دورية أكاديمية
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Experimental Testing of an Approach to Establishing Combined Toxicity of Ternary Nanoparticle Mixtures.

التفاصيل البيبلوغرافية
العنوان: Experimental Testing of an Approach to Establishing Combined Toxicity of Ternary Nanoparticle Mixtures.
المؤلفون: Minigalieva IA; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia., Panov VG; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia.; Institute of Industrial Ecology, Ural Branch of the Russian Academy of Sciences, 620049 Yekaterinburg, Russia., Gurvich VB; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia., Privalova LI; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia., Klinova SV; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia., Katsnelson BA; Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, 620014 Yekaterinburg, Russia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Apr 14; Vol. 23 (8). Date of Electronic Publication: 2022 Apr 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Nanoparticles*/toxicity , Silicon Dioxide*/toxicity, Ions ; Models, Theoretical
مستخلص: Our studies of exposure to binary mixtures of nanoparticles (TiO 2 + SiO 2 ; TiO 2 + Al 2 O 3 and SiO 2 + Al 2 O 3 ) based on mathematical modelling show that their combined subchronic toxicity can either be of an additive type or deviate from it depending on the outcome, dose ratio, and levels of effect. To characterize the type of toxicity of ternary mixtures of nanoparticles, we successfully tested a previously developed approach for assessing the combined toxicity of metal ions. In this approach, the effects are classified by a null, positive, or negative change in the toxicity of binary nanoparticle mixtures when modeled against the toxicity of the third agent added.
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فهرسة مساهمة: Keywords: combined toxicity; mathematical modelling; ternary nanoparticle mixtures
المشرفين على المادة: 0 (Ions)
7631-86-9 (Silicon Dioxide)
تواريخ الأحداث: Date Created: 20220423 Date Completed: 20220426 Latest Revision: 20220429
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9032812
DOI: 10.3390/ijms23084356
PMID: 35457173
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms23084356