دورية أكاديمية
أعرض في EDS

AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis.

التفاصيل البيبلوغرافية
العنوان: AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis.
المؤلفون: Lombardi AF; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA.; Department of Radiology, University of California San Diego, San Diego, CA 92161, USA., Ma Y; Department of Radiology, University of California San Diego, San Diego, CA 92161, USA., Jang H; Department of Radiology, University of California San Diego, San Diego, CA 92161, USA., Jerban S; Department of Radiology, University of California San Diego, San Diego, CA 92161, USA., Tang Q; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA.; Department of Radiology, University of California San Diego, San Diego, CA 92161, USA., Searleman AC; Department of Radiology, University of California San Diego, San Diego, CA 92161, USA., Meyer RS; Orthopaedic Surgery Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA., Du J; Department of Radiology, University of California San Diego, San Diego, CA 92161, USA., Chang EY; Research Service, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USA.; Department of Radiology, University of California San Diego, San Diego, CA 92161, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2022 Apr 18; Vol. 23 (8). Date of Electronic Publication: 2022 Apr 18.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Meniscus*/diagnostic imaging , Osteoarthritis, Knee*/diagnostic imaging, Cartilage ; Humans ; Knee Joint/diagnostic imaging ; Magnetic Resonance Imaging/methods
مستخلص: A relationship between an acidic pH in the joints, osteoarthritis (OA), and pain has been previously demonstrated. Acidosis Chemical Exchange Saturation Transfer (acidoCEST) indirectly measures the extracellular pH through the assessment of the exchange of protons between amide groups on iodinated contrast agents and bulk water. It is possible to estimate the extracellular pH in the osteoarthritic joint using acidoCEST MRI. However, conventional MR sequences cannot image deep layers of cartilage, meniscus, ligaments, and other musculoskeletal tissues that present with short echo time and fast signal decay. Ultrashort echo time (UTE) MRI, on the other hand, has been used successfully to image those joint tissues. Here, our goal is to compare the pH measured in the knee joints of volunteers without OA and patients with severe OA using acidoCEST-UTE MRI. Patients without knee OA and patients with severe OA were examined using acidoCEST-UTE MRI and the mean pH of cartilage, meniscus, and fluid was calculated. Additionally, the relationship between the pH measurements and the Knee Injury and Osteoarthritis Outcome Score (KOOS) was investigated. AcidoCEST-UTE MRI can detect significant differences in the pH of knee cartilage, meniscus, and fluid between joints without and with OA, with OA showing lower pH values. In addition, symptoms and knee-joint function become worse at lower pH measurements.
التعليقات: Erratum in: Int J Mol Sci. 2023 Aug 02;24(15):. (PMID: 37569908)
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معلومات مُعتمدة: R01 AR068987 United States AR NIAMS NIH HHS; R01 AR079484 United States AR NIAMS NIH HHS; R21 AR075851 United States AR NIAMS NIH HHS; N/A GE Healthcare; R01AR068987 United States NH NIH HHS; R01AR078877 United States NH NIH HHS; I01RX002604 United States Department of Veterans Affairs; R01 AR062581 United States AR NIAMS NIH HHS; T32EB005970 United States NH NIH HHS; R01 AR078877 United States AR NIAMS NIH HHS; R01AR075825 United States NH NIH HHS; I01CX001388 United States Department of Veterans Affairs; I01 RX002604 United States RX RRD VA; R01 AR075825 United States AR NIAMS NIH HHS; R21AR075851 United States NH NIH HHS; R01AR062581 United States NH NIH HHS
فهرسة مساهمة: Keywords: CEST; MRI; OA; UTE; cartilage; chemical exchange saturation transfer; meniscus; osteoarthritis; pH; ultrashort echo time
تواريخ الأحداث: Date Created: 20220423 Date Completed: 20220426 Latest Revision: 20230812
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9027981
DOI: 10.3390/ijms23084466
PMID: 35457284
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms23084466