دورية أكاديمية
أعرض في EDS

Bioactive Hydrolysates from Chlorella vulgaris : Optimal Process and Bioactive Properties.

التفاصيل البيبلوغرافية
العنوان: Bioactive Hydrolysates from Chlorella vulgaris : Optimal Process and Bioactive Properties.
المؤلفون: Cunha SA; CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal., Coscueta ER; CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal., Nova P; CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal., Silva JL; Allmicroalgae-Natural Products S.A., R&D Department, Rua 25 de Abril 19, 2445-287 Pataias, Portugal., Pintado MM; CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2022 Apr 13; Vol. 27 (8). Date of Electronic Publication: 2022 Apr 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Chlorella vulgaris* , Microalgae*, Antihypertensive Agents/chemistry ; Antihypertensive Agents/pharmacology ; Antioxidants/pharmacology ; Hydrolysis ; Peptides/chemistry ; Peptides/pharmacology ; Protein Hydrolysates/chemistry ; Protein Hydrolysates/pharmacology
مستخلص: Microalgae have been described as a source of bioactive compounds, such as peptides. Microalgae are easy to produce, making them a sustainable resource for extracting active ingredients for industrial applications. Several microalgae species have interesting protein content, such as Chlorella vulgaris with around 52.2% of protein, making it promising for peptide hydrolysate production. Therefore, this work focused on the production of water-soluble hydrolysates rich in proteins/peptides from the microalgae C. vulgaris and studied bioactive properties. For that, a design of experiments (DOE) was performed to establish the optimal conditions to produce hydrolysates with higher levels of protein, as well as antioxidant and antihypertensive properties. Four experimental factors were considered (cellulase percentage, protease percentage, hydrolysis temperature, and hydrolysis duration) for three responses (protein content, antioxidant activity, and antihypertensive activity). The optimal conditions determined by the DOE allowed producing a scaled-up hydrolysate with 45% protein, with antioxidant activity, measured by oxygen radical absorbance capacity assay, of 1035 µmol TE/g protein, IC 50 for angiotensin-converting enzyme inhibition activity of 286 µg protein/mL, and α-glucosidase inhibition of 31% (30 mg hydrolysate/mL). The obtained hydrolysates can be used as functional ingredients for food and nutraceuticals due to their antioxidant, antihypertensive, and antidiabetic potential. Moreover, the antioxidant potential of the extracts may be relevant for the cosmetic industry, especially in antiaging formulations.
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معلومات مُعتمدة: POCI-01-0247-FEDER-024517 Fundo Europeu de Desenvolvimento Regional; SFRH/BD/144155/2019 Fundação para a Ciência e Tecnologia; SFRH/BD/05747/2020 Fundação para a Ciência e Tecnologia; UIDB/50016/2020 Fundação para a Ciência e Tecnologia
فهرسة مساهمة: Keywords: alternative protein source; antihypertensive; antioxidant; bioactive peptides; enzymatic hydrolysis; functional food; marine hydrolysates; sustainability
المشرفين على المادة: 0 (Antihypertensive Agents)
0 (Antioxidants)
0 (Peptides)
0 (Protein Hydrolysates)
تواريخ الأحداث: Date Created: 20220423 Date Completed: 20220426 Latest Revision: 20220716
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9026812
DOI: 10.3390/molecules27082505
PMID: 35458702
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules27082505