دورية أكاديمية

Exposure to ambient air pollution and osteoarthritis; an animal study.

التفاصيل البيبلوغرافية
العنوان: Exposure to ambient air pollution and osteoarthritis; an animal study.
المؤلفون: Fitriyah A; Faculty of Animal Science, Universitas Nahdlatul Wathan Mataram, Mataram, Indonesia. Electronic address: abyadulfitriyah@yahoo.com., Nikolenko DA; Department of Prosthetic Dentistry, Sechenov First Moscow State Medical University, Moscow, Russia., Abdelbasset WK; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt., Maashi MS; Medical Laboratory Science Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia., Jalil AT; Faculty of Biology and Ecology, Yanka Kupala State University of Grodno, 230023, Grodno, Belarus; College of Technical Engineering, The Islamic University, Najaf, Iraq., Yasin G; Department of Botany University, Bahauddin Zakariya University, Multan, Pakistan., Abdulkadhm MM; Al-Manara College for Medical Sciences, Misan, Iraq., Samieva GU; Doctor of Medical Sciences, Department of Pathologic Physiology, Samarkand State Medical Institute, Samarkand, Uzbekistan., Lafta HA; Al-Nisour University College, Baghdad, Iraq., Abed AM; Department of Air Conditioning and Refrigeration, Al-Mustaqbal University College, Babylon, Iraq., Amaral LS; Department of Bioengineering, University of São Paulo (USP) and Minas Gerais State University (UEMG), Frutal, Minas Gerais, Brazil., Mustafa YF; Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.
المصدر: Chemosphere [Chemosphere] 2022 Aug; Vol. 301, pp. 134698. Date of Electronic Publication: 2022 Apr 23.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Elsevier Science Ltd
Original Publication: Oxford, New York, : Pergamon Press.
مواضيع طبية MeSH: Air Pollutants*/analysis , Air Pollution*/analysis , Environmental Pollutants* , Osteoarthritis*/chemically induced, Animals ; China ; Environmental Exposure/analysis ; Female ; Gases ; Osteocalcin ; Particulate Matter/analysis ; Particulate Matter/toxicity ; Rats
مستخلص: Exposure to air pollution has been associated with many adverse health effects. However, the evidence on the effects on osteoarthritis (OA) is scarce and the potential mechanism is unclear yet. Therefore, this study assessed the effect of exposure to air pollution (gaseous and particulate matter) and OA based on an animal model. We used four groups of female rats, including i) exposure to PMs and gaseous pollutants, ii) exposure only to gaseous pollutants, iii) exposure only to PMs, and iv) control (unexposed) group. The OA biomarkers, i.e., osteocalcin, cartilage oligomeric protein (COMP), and N-Telopeptides of Type I Collagen (NTX-I) and cytokines were measured in the plasma to detect the effect of exposure to ambient air pollution on OA in this animal model. The forced jogging exercises for 1 h and 5 days per week were used to record the physical activities. The median (interquartile range) concentrations of PM 2.5 and PM 10 were 35.9 (15.4) and 47.5 (22.5) μg/m 3 , respectively. The median (interquartile range (IQR)) of PM 2.5 , PM 10 , CO, NO 2 , SO 2 and O 3 in the inlet ambient air were 36.9 (16.9), 51.7 (23.6) μg/m 3 , 16.1 (12.5) ppm, 413.7 (177.1), 334.2 (218.8) and 208.9 (113.1) ppb, respectively. The osteocalcin was significantly lower in PM as well as PM-gaseous exposure groups compared to control. Moreover, expressions of COMP were increased significantly in the PMs and exposure group compared to the control. For the PMs-gaseous exposure group, the COMP expressions were the highest compared to the control group. Similar results were observed for NTX-I. Exposure to PM and gaseous pollutants significantly increased plasma cytokine levels compared to control. Overall, our study showed a significant effect of exposure to PMs and PMs-gaseous exposure with OA in rats. Moreover, we observed a synergistic effect of mixed gaseous-PMs exposure compared to PMs and gaseous pollutants separately.
(Copyright © 2022 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Air pollution; Animal model; Cartilage oligomeric protein; Osteocalcin
المشرفين على المادة: 0 (Air Pollutants)
0 (Environmental Pollutants)
0 (Gases)
0 (Particulate Matter)
104982-03-8 (Osteocalcin)
تواريخ الأحداث: Date Created: 20220426 Date Completed: 20220608 Latest Revision: 20220609
رمز التحديث: 20231215
DOI: 10.1016/j.chemosphere.2022.134698
PMID: 35472612
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1298
DOI:10.1016/j.chemosphere.2022.134698