دورية أكاديمية
Melanocortin MC 4 R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain.
| العنوان: | Melanocortin MC |
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| المؤلفون: | Oliveira V; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Riedl RA; Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Claflin KE; Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa., Mathieu NM; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Ritter ML; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Balapattabi K; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Wackman KK; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Reho JJ; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, Wisconsin., Brozoski DT; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin., Morgan DA; Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa., Cui H; Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa.; Obesity Research and Education Initiative, University of Iowa, Iowa City, Iowa., Rahmouni K; Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa.; Obesity Research and Education Initiative, University of Iowa, Iowa City, Iowa.; Department of Internal Medicine, University of Iowa, Iowa City, Iowa.; Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa.; Iowa City Veterans Affairs Health Care System, Iowa City, Iowa., Burnett CML; Department of Internal Medicine, University of Iowa, Iowa City, Iowa., Nakagawa P; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Sigmund CD; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin., Morselli LL; Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin., Grobe JL; Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.; Comprehensive Rodent Metabolic Phenotyping Core, Medical College of Wisconsin, Milwaukee, Wisconsin.; Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Neuroscience Research Center, Medical College of Wisconsin, Milwaukee, Wisconsin.; Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, Wisconsin. |
| المصدر: | Physiological genomics [Physiol Genomics] 2022 Jun 01; Vol. 54 (6), pp. 196-205. Date of Electronic Publication: 2022 Apr 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 9815683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-2267 (Electronic) Linking ISSN: 10948341 NLM ISO Abbreviation: Physiol Genomics Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, MD : American Physiological Society, c1999- |
| مواضيع طبية MeSH: | Angiotensin II*/pharmacology , Energy Metabolism*/physiology , Leptin*/metabolism , Leptin*/pharmacology , Receptor, Melanocortin, Type 4*/metabolism, Agouti-Related Protein/metabolism ; Animals ; Blood Pressure/physiology ; Brain/metabolism ; Melanocortins/metabolism ; Melanocortins/pharmacology ; Mice |
| مستخلص: | The brain renin-angiotensin system (RAS) is implicated in control of blood pressure (BP), fluid intake, and energy expenditure (EE). Angiotensin II (ANG II) within the arcuate nucleus of the hypothalamus contributes to control of resting metabolic rate (RMR) and thereby EE through its actions on Agouti-related peptide (AgRP) neurons, which also contribute to EE control by leptin. First, we determined that although leptin stimulates EE in control littermates, mice with transgenic activation of the brain RAS (sRA) exhibit increased EE and leptin has no additive effect to exaggerate EE in these mice. These findings led us to hypothesize that leptin and ANG II in the brain stimulate EE through a shared mechanism. Because AgRP signaling to the melanocortin MC |
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| معلومات مُعتمدة: | K01 HL153101 United States HL NHLBI NIH HHS; R01 HL134850 United States HL NHLBI NIH HHS; T35 HL007485 United States HL NHLBI NIH HHS; R01 HL153274 United States HL NHLBI NIH HHS; R35 HL144807 United States HL NHLBI NIH HHS; P01 HL084207 United States HL NHLBI NIH HHS; UL1 TR001436 United States TR NCATS NIH HHS; R01 HL127673 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: angiotensin; blood pressure; energy; melanocortin |
| المشرفين على المادة: | 0 (Agouti-Related Protein) 0 (Leptin) 0 (MC4R protein, mouse) 0 (Melanocortins) 0 (Receptor, Melanocortin, Type 4) 11128-99-7 (Angiotensin II) |
| تواريخ الأحداث: | Date Created: 20220427 Date Completed: 20220526 Latest Revision: 20230602 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC9131927 |
| DOI: | 10.1152/physiolgenomics.00015.2022 |
| PMID: | 35476598 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1531-2267 |
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| DOI: | 10.1152/physiolgenomics.00015.2022 |