دورية أكاديمية
Consumption of a multi-deficient diet causes dynamic changes in the intestinal morphofunctional barrier, body composition and impaired physical development in post-weaning mice.
| العنوان: | Consumption of a multi-deficient diet causes dynamic changes in the intestinal morphofunctional barrier, body composition and impaired physical development in post-weaning mice. |
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| المؤلفون: | Ribeiro SA; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., Rodrigues FAP; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., Clementino MAF; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., Veras HDN; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., Siqueira RCL; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., de Medeiros PHQS; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., Pereira JM; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., Guanabara Júnior MFA; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., de Sousa JK; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., Santos AKS; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., Dos Santos AA; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., Maciel BLL; Nutrition Postgraduation Program and Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil., Havt A; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil., Lima AÂM; Pharmacology Postgraduation Program, Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil. |
| المصدر: | The British journal of nutrition [Br J Nutr] 2023 Mar 14; Vol. 129 (5), pp. 745-758. Date of Electronic Publication: 2022 Apr 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Published on behalf of the Nutrition Society by CABI Publishing Country of Publication: England NLM ID: 0372547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-2662 (Electronic) Linking ISSN: 00071145 NLM ISO Abbreviation: Br J Nutr Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000->: Wallingford, Oxon, UK : Published on behalf of the Nutrition Society by CABI Publishing Original Publication: [Cambridge, New York] Cambridge University Press. |
| مواضيع طبية MeSH: | Lactulose*/metabolism , Diet*, Mice ; Animals ; Occludin/genetics ; Claudin-1/genetics ; Claudin-1/metabolism ; Weaning ; Mice, Inbred C57BL ; Intestinal Mucosa/metabolism ; Body Composition |
| مستخلص: | Few studies have focused on nutrient-deficient diets and associated pathobiological dynamics of body composition and intestinal barrier function. This study evaluated the impact of a nutrient-deficient diet on physical development and intestinal morphofunctional barrier in mice. C57BL/6 (21 days of age) mice were fed a Northeastern Brazil regional basic diet (RBD) or a control diet for 21 d. The animals were subjected to bioimpedance analysis, lactulose test, morphometric analysis and quantitative reverse transcription-PCR to evaluate tight junctions and intestinal transporters. RBD feeding significantly reduced weight ( P < 0·05) from day 5, weight gain from day 3 and tail length from day 14. The intake of RBD reduced total body water, extracellular fluid, fat mass and fat-free mass from day 7 ( P < 0·05). RBD induced changes in the jejunum, with an increase in the villus:crypt ratio on day 7, followed by reduction on days 14 and 21 ( P < 0·05). Lactulose:mannitol ratio increased on day 14 ( P < 0·05). Changes in intestinal barrier function on day 14 were associated with reductions in claudin-1 and occludin, and on day 21, there was a reduction in the levels of claudin-2 and occludin. SGLT-1 levels decreased on day 21. RBD compromises body composition and physical development with dynamic changes in intestinal barrier morphofunctional. RBD is associated with damage to intestinal permeability, reduced levels of claudin-1 and occludin transcripts and return of bowel function in a chronic period. |
| فهرسة مساهمة: | Keywords: Body composition; Intestinal barrier function; Malnutrition; Northeastern Brazil regional basic diet; Tight junction proteins |
| المشرفين على المادة: | 0 (Occludin) 0 (Claudin-1) 4618-18-2 (Lactulose) |
| تواريخ الأحداث: | Date Created: 20220429 Date Completed: 20230301 Latest Revision: 20230328 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1017/S0007114522001271 |
| PMID: | 35485727 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1475-2662 |
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| DOI: | 10.1017/S0007114522001271 |