دورية أكاديمية
What is peripheral spondyloarthritis? Identifying proportion, phenotype and burden in post hoc analysis of the ASAS-PerSpA study.
| العنوان: | What is peripheral spondyloarthritis? Identifying proportion, phenotype and burden in post hoc analysis of the ASAS-PerSpA study. |
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| المؤلفون: | Ziade N; Rheumatology Department, Saint-Joseph University, Beirut, Lebanon; Rheumatology Department, Hotel-Dieu de France Hospital, Beirut, Lebanon. Electronic address: nellziade@yahoo.fr., Rassi J; Surgery Department, Saint-Joseph University, Beirut, Lebanon; Orthopedic Surgery Department, Hotel-Dieu de France Hospital, Beirut, Lebanon. Electronic address: joe.10.rassi@gmail.com., Elzorkany B; Rheumatology Department, Kasr Alaini Hospitals, Cairo University, Egypt. Electronic address: basselelzorkany@gmail.com., Lopez-Medina C; Rheumatology Department, Cochin Hospital, Paris, France; Rheumatology Department, Reina Sofia University Hospital / IMIBIC/ University of Cordoba, Cordoba, Spain. Electronic address: clementinalopezmedina@gmail.com., Gamal SM; Rheumatology Department, Kasr Alaini Hospitals, Cairo University, Egypt. Electronic address: sherif775@hotmail.com., Hlais S; Family Medicine Department, Saint-Joseph University, Beirut, Lebanon; Family Medicine Department, American University of Beirut, Lebanon. Electronic address: sanihlais@gmail.com., Dougados M; Rheumatology Department, Cochin Hospital, Paris, France. Electronic address: maxime.dougados@aphp.fr., Baraliakos X; Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Germany. Electronic address: xenofon.baraliakos@elisabethgruppe.de. |
| المصدر: | Seminars in arthritis and rheumatism [Semin Arthritis Rheum] 2022 Aug; Vol. 55, pp. 152012. Date of Electronic Publication: 2022 Apr 21. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Country of Publication: United States NLM ID: 1306053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-866X (Electronic) Linking ISSN: 00490172 NLM ISO Abbreviation: Semin Arthritis Rheum Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia Pa : W.B. Saunders Original Publication: New York, Stratton. |
| مواضيع طبية MeSH: | Arthritis, Psoriatic*/diagnosis , Arthritis, Psoriatic*/epidemiology , Spondylarthritis*/diagnosis , Spondylarthritis*/epidemiology, Cross-Sectional Studies ; HLA-B27 Antigen/genetics ; Humans ; Phenotype |
| مستخلص: | Background: Little is known about the prevalence, phenotype, and burden of peripheral spondyloarthritis (pSpA). The objective of the study is to compare the phenotype and burden of disease of pure pSpA to that of pure psoriatic arthritis (PsA), pure axial SpA (axSpA), and combined forms of SpA. Methods: This is a post hoc analysis of 4,185 patients from the cross-sectional ASAS-Peripheral involvement in SpA (PerSpA) study. Patients were approached in 2 ways: the first approach was based on the rheumatologist's diagnosis (diagnostic approach) and the second one was based on the fulfillment of ASAS or CASPAR classification criteria (classification criteria approach). Demographics, disease phenotype, and burden were compared among pure pSpA, PsA, axSpA, and the combined forms. Findings: The proportion of pSpA was 31.5% of SpA using the classification criteria approach and 10.3% using the diagnostic approach. pSpA was pure (i.e. without axSpA or PsA) in 16.8% of pSpA using the criteria, and in 62.3% using the diagnostic approach. Using classification criteria and diagnostic approach, respectively, pure pSpA patients had a high prevalence of peripheral joint disease (86 and 96%), synovitis (76 and 91%), and enthesitis (57 and 55%), a positive HLA-B27 in 65 and 59%, a high C-Reactive Protein level in 51% and inflammatory back pain in 52 and 42%. However, compared to pure PsA and pure axSpA, they had a significantly higher disease burden, but lower use of biologics using both approaches. Interpretation: The proportion of pSpA varies when using the classification criteria or the diagnostic approach. pSpA occurred in a pure form less frequently than PsA and axSpA and had intermediate features but a higher disease burden. Funding: The PerSpA main study has been conducted under the umbrella of ASAS thanks to unrestricted grants from PFIZER, LILLY, ABBVIE, NOVARTIS, UCB, JANSSEN, MERCK. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Disease burden; Disease definition; Epidemiology; Peripheral spondyloarthritis; Spondyloarthritis |
| المشرفين على المادة: | 0 (HLA-B27 Antigen) |
| تواريخ الأحداث: | Date Created: 20220430 Date Completed: 20220707 Latest Revision: 20220801 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.semarthrit.2022.152012 |
| PMID: | 35489171 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-866X |
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| DOI: | 10.1016/j.semarthrit.2022.152012 |