دورية أكاديمية
أعرض في EDS

Photodynamic therapy and photobiomodulation therapy in zoledronic acid-induced osteonecrosis in rats.

التفاصيل البيبلوغرافية
العنوان: Photodynamic therapy and photobiomodulation therapy in zoledronic acid-induced osteonecrosis in rats.
المؤلفون: Silva PGB; Department of Dentistry, Laboratory of Oral Pathology, Unichristus, Fortaleza, Ceará, Brazil; Department of Clinical Dentistry, Division of Oral Pathology, School of Pharmacy, Dentistry and Nursing, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., Praxedes Neto RALP; Department of Dentistry, Laboratory of Oral Pathology, Unichristus, Fortaleza, Ceará, Brazil., Lima LA; Department of Dentistry, Laboratory of Oral Pathology, Unichristus, Fortaleza, Ceará, Brazil; Department of Clinical Dentistry, Division of Oral Pathology, School of Pharmacy, Dentistry and Nursing, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., Lemos JVM; Department of Dentistry, Laboratory of Oral Pathology, Unichristus, Fortaleza, Ceará, Brazil; Department of Clinical Dentistry, Division of Oral Pathology, School of Pharmacy, Dentistry and Nursing, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., Rodrigues MIQ; Department of Clinical Dentistry, Division of Oral Pathology, School of Pharmacy, Dentistry and Nursing, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., Alves APNN; Department of Clinical Dentistry, Division of Oral Pathology, School of Pharmacy, Dentistry and Nursing, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., Dantas TS; Department of Dentistry, Laboratory of Oral Pathology, Unichristus, Fortaleza, Ceará, Brazil; Department of Clinical Dentistry, Division of Oral Pathology, School of Pharmacy, Dentistry and Nursing, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., Lima RA; Department of Dentistry, Laboratory of Oral Pathology, Unichristus, Fortaleza, Ceará, Brazil. Electronic address: ramille.lima@unichristus.edu.br.
المصدر: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2022 Jun; Vol. 38, pp. 102889. Date of Electronic Publication: 2022 Apr 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101226123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1597 (Electronic) Linking ISSN: 15721000 NLM ISO Abbreviation: Photodiagnosis Photodyn Ther Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; Boston : Elsevier, c2004-
مواضيع طبية MeSH: Bisphosphonate-Associated Osteonecrosis of the Jaw*/drug therapy , Bone Density Conservation Agents*/therapeutic use , Low-Level Light Therapy* , Photochemotherapy*/methods, Animals ; Diphosphonates/pharmacology ; Diphosphonates/therapeutic use ; Imidazoles/pharmacology ; Rats ; Zoledronic Acid/therapeutic use
مستخلص: Background: This study investigated the effect of antimicrobial photodynamic therapy (PDT), using methylene blue (MBO) and photobiomodulation therapy (PT), on the alveolar bone of rats submitted to bisphosphonate-induced osteonecrosis of the maxillaries (OMB) model using zoledronic acid (ZA).
Methods: Sixty rats divided into six groups were used: SALINE, PDT, ZA, ZA+PDT, ZA+PT, and ZA+MBO. Three weekly administrations (Days 0, 7, and 14) of ZA 0.20 mg/kg or saline solution were performed. After one month (Day 42), the exodontia of the left lower first molars were performed. An additional dose of ZA was administered at Day 49. PDT was performed on days 42, 45, 49, and 54. One month after exodontia (Day 70), the animals were euthanized to obtain samples for imaging and microscopic analysis. ANOVA/Bonferroni tests were used for statistical analysis.
Results: The ZA+PDT group showed a significantly lower percentage of apoptotic osteocytes than the ZA group (p < 0.001). The ZA+MBO, ZA+PT, and PDT groups significantly reduced the number of mononuclear cells compared to the ZA group (p < 0.001). The ZA+PT and ZA+PDT groups showed a significant reduction in the number of CD 68+ (p < 0.001) and CD3+ (p = 0.002) cells compared to the ZA group. The number of cells expressing INF-y had a significant reduction in the groups co-treated with PT and PDT compared to the ZA group (p < 0.001).
Conclusions: We conclude that PDT and PT attenuated the severity of OMB and the inflammatory process due to a reduction of macrophages, T lymphocytes, and cytokines that stimulate the activity of these cells.
(Copyright © 2022. Published by Elsevier B.V.)
فهرسة مساهمة: Keywords: Bisphosphonate-AssociatedOsteonecrosisof the Jaw; Low-Level Light Therapy; Maxillaries osteonecrosis associated to bisphosphonates; Photodynamic therapy; Zoledronic acid
المشرفين على المادة: 0 (Bone Density Conservation Agents)
0 (Diphosphonates)
0 (Imidazoles)
6XC1PAD3KF (Zoledronic Acid)
تواريخ الأحداث: Date Created: 20220430 Date Completed: 20220608 Latest Revision: 20220608
رمز التحديث: 20221213
DOI: 10.1016/j.pdpdt.2022.102889
PMID: 35489689
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-1597
DOI:10.1016/j.pdpdt.2022.102889