دورية أكاديمية
Trans-urocanic acid facilitates spatial memory, implications for Alzheimer's disease.
| العنوان: | Trans-urocanic acid facilitates spatial memory, implications for Alzheimer's disease. |
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| المؤلفون: | Yu XD; School of Basic Medical Sciences, Shaoyang University, 422000, Shaoyang, China., Li A; School of Basic Medical Sciences, Shaoyang University, 422000, Shaoyang, China., Li XY; College of Chinese Medicine, Hunan University of Chinese Medicine, , 410208 Changsha, Hunan, China., Zhou Y; School of Basic Medical Sciences, Shaoyang University, 422000, Shaoyang, China., Li X; School of Basic Medical Sciences, Shaoyang University, 422000, Shaoyang, China., He Z; School of Basic Medical Sciences, Shaoyang University, 422000, Shaoyang, China., Wang L; School of Basic Medical Sciences, Shaoyang University, 422000, Shaoyang, China., Reilly J; Department of Biological and Biomedical Sciences, Glasgow Caledonian University, G4 0BA, Glasgow, United Kingdom., Tan Z; College of Chinese Medicine, Hunan University of Chinese Medicine, , 410208 Changsha, Hunan, China., Xiao ZY; The First Affiliated Hospital,Department of Critical Care Medicine,Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, China. Electronic address: xiaozy_nurse@163.com., Shu X; School of Basic Medical Sciences, Shaoyang University, 422000, Shaoyang, China; Department of Biological and Biomedical Sciences, Glasgow Caledonian University, G4 0BA, Glasgow, United Kingdom. Electronic address: Xinhua.Shu@gcu.ac.uk. |
| المصدر: | Physiology & behavior [Physiol Behav] 2022 Aug 01; Vol. 252, pp. 113827. Date of Electronic Publication: 2022 Apr 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 0151504 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-507X (Electronic) Linking ISSN: 00319384 NLM ISO Abbreviation: Physiol Behav Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York NY : Elsevier Science Original Publication: Oxford, Eng., Long Island City, Pergamon Press. |
| مواضيع طبية MeSH: | Alzheimer Disease*/drug therapy , Urocanic Acid*/metabolism , Urocanic Acid*/pharmacology, Hippocampus/metabolism ; Humans ; NF-kappa B/metabolism ; Spatial Memory ; Ultraviolet Rays |
| مستخلص: | Trans-urocanic acid (trans-UCA) is an isomer of cis-UCA and is widely distributed in the brain, predominantly in the hippocampus and prefrontal cortex. Previous studies have investigated the role of trans-UCA in non-spatial memory; however, its influence on spatial memory remains unclear. In the present study, network pharmacology strategy and behavioral testing were used to evaluate the role of trans-UCA in spatial memory and predict its possible mechanism. The results showed that there are 40 intersecting targets between trans-UCA and spatial memory identified by several databases and Venn diagram, indicating that trans-UCA may be involved in spatial memory. Behavioral results show that trans-UCA facilitates spatial working memory in the Y-maze test as well as spatial recognition memory acquisition, consolidation and retrieval in an object location recognition (OLR) task. Furthermore, PPI (protein-protein interaction) network analysis, GO (gene ontology) and KEGG (Kyoto encyclopedia of genes and genomes) pathway enrichment analyses show that the molecular mechanisms underlying the enhancing effect of trans-UCA on spatial memory are mainly associated with the regulation of insulin, mitogen-activated protein kinase (MAPK) and nuclear factor Kappa B (NF-κB) signaling pathways, serotonergic synapse and arginine and proline metabolism. The results of this study suggest that trans-UCA facilitates spatial memory in the Y-maze test and OLR task and may offer therapeutic potential for Alzheimer's disease (AD). The underlying mechanisms predicted by network pharmacology should be further verified. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alzheimer's disease; Network pharmacology; Spatial memory; Trans-urocanic acid |
| المشرفين على المادة: | 0 (NF-kappa B) G8D26XJJ3B (Urocanic Acid) |
| تواريخ الأحداث: | Date Created: 20220501 Date Completed: 20220606 Latest Revision: 20220613 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.physbeh.2022.113827 |
| PMID: | 35490778 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-507X |
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| DOI: | 10.1016/j.physbeh.2022.113827 |